Phytoestrogens and Effects on Health

Year 2005, Volume: 2 Issue: 2, 91 - 95, 01.06.2005

N. İnanç Ş. Tuna

Abstract

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Keywords

Fitoöstojenler, sağlık

Fitoöstrojenler ve Sağlıktaki Etkileri

Abstract

Bitki kökenli östrojenler veya östrojene benzer etkiye sahip olan bileşikler “fitoöstrojenler” olarak adlandırılır. Değişik derecelerde östrojenik etkinliğe sahip olan fitoöstrojenler, organizmada bulunan doğal östrojenlerle yarışa girer,reseptörlere bağlanarak etkinlik gösterirler. Fitoöstrojenler; izoflavonoidler, stilbenler, lignanlar ve kumestanlar olmaküzere dört alt gruba ayrılmaktadır. İzoflavonlar daha çok soya ve soya ürünlerinde ve diğer kurubaklagillerde, lignanlar;en çok keten tohumu, çavdar kepeği, kiraz, çilek gibi meyvelerde, stilbenler; yer fıstığı ve kırmızı şarapta, kumestanlarise kurubaklagillerde bulunur. Fitoöstrojenler, östrojenik ve antiöstrojenik, antioksidant, antiproliferatif veantianjiogenetik, antinflamatuar özellikler gösterebilmektedir. Östrojenik ve antiöstrojenik özellikleri ile daha çok menopoz veya osteoporoz ile ilişkili iken, antioksidant özellikleri ile kanserle ilişkili olduğu bildirilmiştir. Ancak yapılan çalışmalarda fitoöstrojenlerin etki mekanizmaları henüz tam olarak açıklanamamakta, bu bileşiklerin yaygın olarak kullanımının önerilebilmesi için daha çok çalışmaya ihtiyaç olduğu belirtilmektedir. Bu derlemede fitoöstrojenler ve sağlıktakietkileri ile ilgili makaleler özetlenmiştir

Keywords

Fitoöstojenler, sağlık

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• ipriflavone and estrogen replacement on bone mineral
• postmenopausal women. Maturitas, 28: 75– 81. metabolism in
• Golgberg G. 2001. Plants: Diet and Health. British Publishing, pp. 138–146. Blackwell
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• Ulusoylu M, 2004. İzoflavonlar. Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi ABD.www.nutrisyon.com.
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