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The Effect of Boric Acid on Blood Chemistry in Rabbits

Year 2013, Volume: 10 Issue: 2, - , 01.06.2013

P. Yiğit M. Eren Z.s. Sarıca M. Şentürk

Abstract

This study was carried out to investigate the influence of boric acid (BA) on blood chemistry in rabbits.Forty, 16 weeks old, New Zealand rabbits were assigned to 4 groups consisting of 10 rabbits in each group. Thegroups received the following treatment: group 1: control group without treatment, group 2: 31.25 mg /kg, group 3: 62.5mg/kg and group 4: 125 mg/kg (bw./day) boric acid (HBO ) was administered with drinking water for 5 weeks. At theend of the experiment, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) activities,glucose, total cholesterol, HDL-cholesterol, triglyceride, total protein, albumin, globulin, urea, creatinine, calcium (Ca),inorganic phosphorus (Pi), magnesium (Mg), sodium (Na), potassium (K), iron (Fe), copper (Cu), zinc (Zn), manganese(Mn), selenium (Se), chromium (Cr) and boron (B) levels were determined. Alkaline phosphatase enzyme activity(P<0.001) and Pi concentrations (P<0.001) in serum in all of the BA groups, Zn (P<0.05) and B (P<0.001)concentrations in 62.5 and 125 mg/kg (bw.) BA given groups were significantly higher. Other blood parameters werenot affected by BA. As a result, 31.25, 62.5 and 125 mg/kg (bw/day) boric acid increased serum ALP enzyme activity,Pi, Zn and B concentrations related to bone metabolism, but no effect on other enzymes and metabolites have beenidentified, therefore, further studies with different doses and different forms of B may be valuable in rabbits.

Keywords

Blood chemistry boric acid rabbit

References

  • Armstrong TA, Flowers WL, Spears, JW, Nielsen FH. Long-term effects of boron s u p p l e m e n t a t i o n o n r e p r o d u c t i v e characteristics and bone mechanical properties in gilts. J Anim Sci 2002; 80: 154-61.
  • Armstrong TA, Spears JW, Crenshaw TD, Nielsen FH. Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites. J Nutr 2000; 139: 2575-81.
  • Armstrong TA, Spears JW, Lloyd KE. Inflammatory response, growth, and thyroid hormone concentrations are affected by longterm boron supplementation in gilts. J Anim Sci 2001; 79: 1549-56.
  • Armstrong TA, Spears JW. Effect of boron supplementation of pig diets on the production of tumor necrosis factor-α and interferon-γ. J Anim Sci 2003; 81: 2552-61.
  • Armstrong TA, Spears JW. Effects of dietary boron on growth performance, calcium and phosphorus metabolism, and bone mechanical proprties in gowing barrows. J Anim Sci 2001; 79: 3120-27.
  • August P. Distrubition of boron in the environment. Biol Trace Elem 1998; 66(1-3): 131Aysan E, Şahin F, Telci D, Yalvaç ME, Emre SH, Karaca Ç, Müslümanoğlu M. Body weight reducing effect of oral boric acid intake. Int J Med Sci 2011; 8(8): 653-58.
  • Bakken NA, Hunt CD. Dietary boron decreases peak pancreatic in situ insulin release in chicks and plasma insulin concentrations in rats regardless of vitamin D or magnesium status. J Nutr 2003; 133(11): 3577-8
  • Başoglu AN. Başpınar, Ozturk SA, Akalın PP. Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rabbits. Trace Elem Electrolytes 2010; 27(4): 225-31.
  • Başoğlu A, Sevinç M, Güzelbektaş H, Civelek T. Short communication: Effect of boraks on serum lipid profile in dogs. Online J Vet Res 2000; 4(6): 153-6.
  • Beattie JH, Peace HS. The influence of a lowboron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr 1993; 69(3): 871-84.
  • Benderdour M, Bui-Van T, Dicko A, Belleville F. In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol 1998; 12(1): 2-7 (Abstr).
  • Bozkurt M, Küçükyılmaz K, Çatlı AU, Çınar M, Çabuk M, Bintaş E. Effects of boron supplementation to diets deficient in calcium and phosphorus on performance with some serum, bone and fecal characteristics of broiler chickens. Asian-Aust J Anim Sci 2012; 25(2): 248-5
  • Brown TF, McCormick ME, Morris DR, Zeringue LK. Effects of dietary boron on mineral balance in sheep. Nutr Res 1989; 9(5): 503Butterwick L, De Oude N, Raymond K. Safety assessment of boron in aquatic and terrestrial environments. Ecotoxicol Environ Safety 1989; 17(3): 339-71.
  • Chapin RE, Ku WW, Kenney MA, McCoy H, Gladen B., Wine RN, Wilson R, Elwell MR. The effects of dietary boron on bone strength in rats. Fundam Applied Toxicol 1997; 35(2): 205Devirian TA, Volpe ST. The physiological effects of dietary boron. Crit Rev Food Sci 2003; 43(2): 219-31.
  • Dupre JN, Keenan MJ, Hegsted M, Brudevold AM. Effects of dietary boron in rats fed a vitamin D-deficient diet. Environ Health Perspect 1994; 102(Suppl 7): 55-8.
  • Elliot MA, Edwards HM. Studies to detemine whether an interaction exist among boron, calcium, and cholecalciferol on the skeletal development of broiler chickens. Poultry Sci 1992; 71(4): 677-90.
  • Eren M, Kocaoğlu Güçlü B, Uyanik F, Karabulut N. The effects of dietary Boron supplementation on performance, carcass composition and serum lipids in Japanese quails. J Anim Vet Adv 2006 ; 5(12): 1105-8.
  • Eren M, Uyanık F, Güçlü BK, Atasever A. The influence of dietary boron supplementation on performance, some biochemical parameters and organs in broilers. Asian J Anim Vet Adv 2012; 7(11): 1079-89.
  • Eren M, Uyanık F, Küçükersan S. The influence of dietary boron supplementation on egg quality and serum calcium, inorganic phosphorus, magnesium levels and alkaline phosphatase activity in laying hens. Res Vet Sci 2004; 76, 203-10.
  • Geyikoğlu F, Türkez H. Effects of boric acid on aluminium-mediated ionic changes in rat serum. IV. Uluslararası Bor Sempozyumu. Ekim, 15-17, 2009; Eskişehir-Türkiye.
  • Hall IH, Spielvogel BF, Griffin TS, Docks EL, Brotherton RJ. The effects of boron hypolipidemic agents on LDL and HDL receptor binding and related enzyme activities of rat hepatocytes, aorta cells and human fibroblasts. Res Com Chem Path Pharm 1989; 65(3): 297-317.
  • Hansch R, Mendel RR. Physiological functions of mineral micronutritients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl). Plant Biol 2009; 12(3): 259-66.
  • Hegsted M, Keenan MJ, Siver F, Wozniak P. Effect of boron on vitamin D deficient rats. Biol Trace Elem Res 1991; 28(3): 243-55.
  • Heindel JJ, Price CJ, Schwetz BA. The developmental toxicity of boric acid in mice, rats and rabbits. Environ Health Perspect 1994; 102 (Suppl 7): 107-12.
  • Howe PD. A rewiev of boron effects in the environment. Biol Trace Elem 1998; 66 (1-3): 153-66 (Abstr).
  • Hunt CD, Herbel JL, Idso JP. Dietary boron modifies the effects of vitamin D 3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res 1994; 9(2): 171-82 (Abstr).
  • Hunt CD, Herbel JL. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D 3 -deprived rat. Magnes Trace Elem 1991-92; 10(5-6): 387 -40
  • Hunt CD. Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biol Trace Elem Res 1989; 22(2): 201
  • Hunt CD. Dietary boron: An overview of the evidence for its role in immune function. The J Trace Elem Exp Med 2003; 16(4): 291-306.
  • İnce S, Keleş H, Erdoğan M, Hazman O, Küçükkurt İ. Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem Toxicol 2012; 35(3): 285-92.
  • İnce S, Küçükkurt İ, Ciğerci İH, Fidan AF, Eryavuz A. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol 2010; 24(3): 161-4.
  • Karabulut N, Eren M. Besi bıldırcını yemlerine bor ilavesinin serum kalsiyum, inorganik fosfor ve magnezyum düzeyleri ile alkali fosfataz aktivitesine etkisi. Erciyes Üniv Sağlık Bilim Derg 2006; 15(1): 8-12.
  • King N, Odom TW, Sampson HW, Pardeu S. In ovo administration of boron or sodium aluminosilicate alters mineralization in the turkey. Nutr Res 1993; 13(1): 77-85.
  • Kurtoğlu F, Kurtoğlu V, Çelik İ, Keçeci T, Nizamlıoğlu M. Effects of dietary boron supplementation on biochemical parameters, peripheral blood lymphocytes, splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol (vitamin D 3 ) content. Br Poult Sci 2005; 46(1): 87-96.
  • Kurtoğlu V, Coşkun B, Şeker E, Balevi T, Çetingül I.S. Effects of boron supplementation on performance and some serum biochemical parameters in laying hens. Revue Med Vet 2002; 153(12): 823-8.
  • Kurtoğlu V, Kurtoğlu F, Coşkun B. Effects of boron supplementation of adequate and inadequate vitamin D 3 -containing diet on performance and serum biochemical characters of broiler chickens. Res Vet Sci 2001; 71: 183-7.
  • Laila EAN, Adel EAA. Effect of boron deficiency on some physiological and biochemical aspects during the developmental stages of wheat (Triticum aestivum L.) plant. J Biol Sci 2002; 2(7): 470-6.
  • Mc Dowell LR. Minerals in Animal and Human Nutrition. Academic Press Inc. London. 1992; 367-70.
  • Mızrak C, Yenice E, Can M, Yıldırım U, Atık Z. Effects of dietary boron on performance, egg production, egg quality and some bone parameters in layer hens. S Afr J Anim Sci 2010; 40(3): 257-64.
  • Miljkovic D, Natasha M, Mark MF. Up-regulatory impact of boron on vitamin D function-does it reflect inhibition of 24hydroylase. Med Hypotheses 2004; 63(6): 1054Moseman RF. Chemical disposition of boron in animals and humans. Environ Health Perspect. 1994; 102(Suppl 7): 113-7.
  • Naghii MR, Samman S. The effect of boron on plasma testosterone and plasma lipids in rats. Nutr Res 1997; 17(3): 523-31.
  • Naghii MR, Samman S. The role of boron in nutrition and metabolism. Prog Food Nutr Sci 1993; 17(4): 331-49.
  • Nielsen FH, Hunt CD, Mu LM, Hunt JR. Effect of boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1(5): 394-97.
  • Nielsen FH, Schuler TR, Zimmerman TJ, Uthus EO. Dietary magnesium, manganese and boron affect the response of rats to high dietary aluminium. Magnes 1988; 7(3): 133-47 (Abstr).
  • Nielsen FH, Schuler TR. Studies of the interaction between boron and calcium, and its modification by magnesium and potassium in rats. Effects on growth, blood variables, and bone mineral composition. Biol Trace Elem Res 1992; 35(3): 225-37 (Abstr).
  • Nielsen FH. Boron-an overlooked elements of potential nutritional importance. Nutr Today 1988; 4-7.
  • Nielsen FH. Dietary fat composition modifies the effect of boron on bone characteristics and plasma lipids in rats. Biofactors 2004; 20 (3): 161-71 (Abstr).
  • Pawa S, Ali S. Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact 2006; 160(2): 89-98.
  • Price CJ, Melissa CM, Myers CB, Seely JC, Heindel JJ, Schwetz BA. The developmental toxicity of boric acid in rabbits. Fundamental Appl Toxicol 1996; 34(2): 176-87.
  • Qin X, Klandorf H. Effect of dietary boron supplementation on egg production, shell quality, and calcium metabolism in aged broiler breeder hens. Poultry Sci 1991; 70(10): 2131
  • Rossi AF, Miles RD, Damron BL, Flunker LK. Effects of dietary boron supplementation on broilers. Poultry Sci 1993; 72(11): 2124-30.
  • Shaaban MM. Role of boron in plant nutrition and human health. Am J Plant Physiol 2010;
  • (5): 224-40.
  • Sisk DB, Colvin BM, Merrill A,Bondari K, Bowen JM. Experimental acute inorganic boron toxicosis in the goat: Effects on serum chemistry and CSF biogenic amines. Vet Hum Toxicol 1990; 32(3): 205-11.
  • Tariq M, Mott CJB. The significance of boron in plant nutrition and environment-A review. J Agron 2007; 6(1): 1-10.
  • Türkez H. Effects of boric acid and borax on titanium dioxide genotoxicity. J Appl Toxicol 2008; 28(5): 658-64.
  • WHO. Boron. International Programme on Chemical Safety. Environmental Health Criteria 204. Ohio, USA.1998; 1-201.
  • Wilson JH, Ruszler PL. Effects of dietary boron supplementation on laying hens. Br Poultry Sci 1996; 37(4): 723-29 (Abstr).
  • Wilson JH, Ruszler PL. Long term effects of boron on layer bone strength and production parameters. Br Poult Sci 1998; 39(1): 11-5.
  • Woods WG. An introduction to boron:history, sources, uses, and chemistry. Environ Health Perspect 1994; 102 (Suppl 7): 5-11.
  • Yeşilbağ D, Eren M. Effects of dietary boric acid supplementation of performance, egg shell quality and some serum parameters in aged laying hens. Turk J Vet Anim Sci 2008; 32(2):113-7.

Tavşanlarda Borik Asidin Kan Kimyasına Etkisi

Year 2013, Volume: 10 Issue: 2, - , 01.06.2013

P. Yiğit M. Eren Z.s. Sarıca M. Şentürk

Abstract

Bu çalışmada, tavşanlarda borik asidin (BA) bazı kan parametrelerine etkisinin araştırılması amaçlanmıştır. Kırkadet 16 haftalık Yeni Zelanda tavşanı, her biri 10 adetten oluşan 4 gruba ayrılmıştır. Birinci grup kontrol grubunu oluşturmuştur. İkinci gruba 31.25 mg /kg, 3. gruba 62.5 mg/kg ve 4. gruba 125 mg/kg (canlı ağırlık, gün) borik asit (HBO ) içme suyuna katılarak 5 hafta süresince verilmiştir. Denemenin sonunda hayvanların serumlarında aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), gamma glutamil transpeptidaz (GGT), alkali fosfataz (ALP), laktatdehidrogenaz (LDH) ve kreatin kinaz (CK) aktiviteleri ile glikoz, total kolesterol, HDL-kolesterol, trigliserid, total protein,albumin, globulin, üre, kreatinin, kalsiyum (Ca), inorganik fosfor (iP), magnezyum (Mg), sodyum (Na), potasyum (K),demir (Fe), bakır (Cu), çinko (Zn), manganez (Mn), selenyum (Se), krom (Cr) ve bor (B) düzeyleri belirlenmiştir. SerumALP enzim aktivitesi (P<0.001) ile iP konsantrasyonu (P<0,01) BA verilen tüm gruplarda, Zn (P<0.05) ve B (P<0.001)konsantrasyonları da 62.5 ve 125 mg/kg (canlı ağırlık) BA verilen gruplarda önemli düzeyde yüksek bulunmuştur.Sonuç olarak, tavşanlarda 31.25, 62.5 ve 125 mg/kg (canlı ağırlık/gün) borik asidin kemik metabolizması ile ilişkili parametrelerden olan serum alkali fosfataz enzim aktivitesi ile fosfor, çinko ve borun serumdaki düzeylerini artırdığı, ancakdiğer enzim ve metabolitleri etkilemediği belirlenmiş olup, bu hayvanlarda bor iz elementinin farklı dozlarda ve farklıformlarının kullanıldığı çalışmaların yapılmasında yarar olacağı kanaatine varılmıştır.

Keywords

Borik asit kan kimyası tavşan

References

  • Armstrong TA, Flowers WL, Spears, JW, Nielsen FH. Long-term effects of boron s u p p l e m e n t a t i o n o n r e p r o d u c t i v e characteristics and bone mechanical properties in gilts. J Anim Sci 2002; 80: 154-61.
  • Armstrong TA, Spears JW, Crenshaw TD, Nielsen FH. Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites. J Nutr 2000; 139: 2575-81.
  • Armstrong TA, Spears JW, Lloyd KE. Inflammatory response, growth, and thyroid hormone concentrations are affected by longterm boron supplementation in gilts. J Anim Sci 2001; 79: 1549-56.
  • Armstrong TA, Spears JW. Effect of boron supplementation of pig diets on the production of tumor necrosis factor-α and interferon-γ. J Anim Sci 2003; 81: 2552-61.
  • Armstrong TA, Spears JW. Effects of dietary boron on growth performance, calcium and phosphorus metabolism, and bone mechanical proprties in gowing barrows. J Anim Sci 2001; 79: 3120-27.
  • August P. Distrubition of boron in the environment. Biol Trace Elem 1998; 66(1-3): 131Aysan E, Şahin F, Telci D, Yalvaç ME, Emre SH, Karaca Ç, Müslümanoğlu M. Body weight reducing effect of oral boric acid intake. Int J Med Sci 2011; 8(8): 653-58.
  • Bakken NA, Hunt CD. Dietary boron decreases peak pancreatic in situ insulin release in chicks and plasma insulin concentrations in rats regardless of vitamin D or magnesium status. J Nutr 2003; 133(11): 3577-8
  • Başoglu AN. Başpınar, Ozturk SA, Akalın PP. Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rabbits. Trace Elem Electrolytes 2010; 27(4): 225-31.
  • Başoğlu A, Sevinç M, Güzelbektaş H, Civelek T. Short communication: Effect of boraks on serum lipid profile in dogs. Online J Vet Res 2000; 4(6): 153-6.
  • Beattie JH, Peace HS. The influence of a lowboron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr 1993; 69(3): 871-84.
  • Benderdour M, Bui-Van T, Dicko A, Belleville F. In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol 1998; 12(1): 2-7 (Abstr).
  • Bozkurt M, Küçükyılmaz K, Çatlı AU, Çınar M, Çabuk M, Bintaş E. Effects of boron supplementation to diets deficient in calcium and phosphorus on performance with some serum, bone and fecal characteristics of broiler chickens. Asian-Aust J Anim Sci 2012; 25(2): 248-5
  • Brown TF, McCormick ME, Morris DR, Zeringue LK. Effects of dietary boron on mineral balance in sheep. Nutr Res 1989; 9(5): 503Butterwick L, De Oude N, Raymond K. Safety assessment of boron in aquatic and terrestrial environments. Ecotoxicol Environ Safety 1989; 17(3): 339-71.
  • Chapin RE, Ku WW, Kenney MA, McCoy H, Gladen B., Wine RN, Wilson R, Elwell MR. The effects of dietary boron on bone strength in rats. Fundam Applied Toxicol 1997; 35(2): 205Devirian TA, Volpe ST. The physiological effects of dietary boron. Crit Rev Food Sci 2003; 43(2): 219-31.
  • Dupre JN, Keenan MJ, Hegsted M, Brudevold AM. Effects of dietary boron in rats fed a vitamin D-deficient diet. Environ Health Perspect 1994; 102(Suppl 7): 55-8.
  • Elliot MA, Edwards HM. Studies to detemine whether an interaction exist among boron, calcium, and cholecalciferol on the skeletal development of broiler chickens. Poultry Sci 1992; 71(4): 677-90.
  • Eren M, Kocaoğlu Güçlü B, Uyanik F, Karabulut N. The effects of dietary Boron supplementation on performance, carcass composition and serum lipids in Japanese quails. J Anim Vet Adv 2006 ; 5(12): 1105-8.
  • Eren M, Uyanık F, Güçlü BK, Atasever A. The influence of dietary boron supplementation on performance, some biochemical parameters and organs in broilers. Asian J Anim Vet Adv 2012; 7(11): 1079-89.
  • Eren M, Uyanık F, Küçükersan S. The influence of dietary boron supplementation on egg quality and serum calcium, inorganic phosphorus, magnesium levels and alkaline phosphatase activity in laying hens. Res Vet Sci 2004; 76, 203-10.
  • Geyikoğlu F, Türkez H. Effects of boric acid on aluminium-mediated ionic changes in rat serum. IV. Uluslararası Bor Sempozyumu. Ekim, 15-17, 2009; Eskişehir-Türkiye.
  • Hall IH, Spielvogel BF, Griffin TS, Docks EL, Brotherton RJ. The effects of boron hypolipidemic agents on LDL and HDL receptor binding and related enzyme activities of rat hepatocytes, aorta cells and human fibroblasts. Res Com Chem Path Pharm 1989; 65(3): 297-317.
  • Hansch R, Mendel RR. Physiological functions of mineral micronutritients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl). Plant Biol 2009; 12(3): 259-66.
  • Hegsted M, Keenan MJ, Siver F, Wozniak P. Effect of boron on vitamin D deficient rats. Biol Trace Elem Res 1991; 28(3): 243-55.
  • Heindel JJ, Price CJ, Schwetz BA. The developmental toxicity of boric acid in mice, rats and rabbits. Environ Health Perspect 1994; 102 (Suppl 7): 107-12.
  • Howe PD. A rewiev of boron effects in the environment. Biol Trace Elem 1998; 66 (1-3): 153-66 (Abstr).
  • Hunt CD, Herbel JL, Idso JP. Dietary boron modifies the effects of vitamin D 3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res 1994; 9(2): 171-82 (Abstr).
  • Hunt CD, Herbel JL. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D 3 -deprived rat. Magnes Trace Elem 1991-92; 10(5-6): 387 -40
  • Hunt CD. Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biol Trace Elem Res 1989; 22(2): 201
  • Hunt CD. Dietary boron: An overview of the evidence for its role in immune function. The J Trace Elem Exp Med 2003; 16(4): 291-306.
  • İnce S, Keleş H, Erdoğan M, Hazman O, Küçükkurt İ. Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem Toxicol 2012; 35(3): 285-92.
  • İnce S, Küçükkurt İ, Ciğerci İH, Fidan AF, Eryavuz A. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol 2010; 24(3): 161-4.
  • Karabulut N, Eren M. Besi bıldırcını yemlerine bor ilavesinin serum kalsiyum, inorganik fosfor ve magnezyum düzeyleri ile alkali fosfataz aktivitesine etkisi. Erciyes Üniv Sağlık Bilim Derg 2006; 15(1): 8-12.
  • King N, Odom TW, Sampson HW, Pardeu S. In ovo administration of boron or sodium aluminosilicate alters mineralization in the turkey. Nutr Res 1993; 13(1): 77-85.
  • Kurtoğlu F, Kurtoğlu V, Çelik İ, Keçeci T, Nizamlıoğlu M. Effects of dietary boron supplementation on biochemical parameters, peripheral blood lymphocytes, splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol (vitamin D 3 ) content. Br Poult Sci 2005; 46(1): 87-96.
  • Kurtoğlu V, Coşkun B, Şeker E, Balevi T, Çetingül I.S. Effects of boron supplementation on performance and some serum biochemical parameters in laying hens. Revue Med Vet 2002; 153(12): 823-8.
  • Kurtoğlu V, Kurtoğlu F, Coşkun B. Effects of boron supplementation of adequate and inadequate vitamin D 3 -containing diet on performance and serum biochemical characters of broiler chickens. Res Vet Sci 2001; 71: 183-7.
  • Laila EAN, Adel EAA. Effect of boron deficiency on some physiological and biochemical aspects during the developmental stages of wheat (Triticum aestivum L.) plant. J Biol Sci 2002; 2(7): 470-6.
  • Mc Dowell LR. Minerals in Animal and Human Nutrition. Academic Press Inc. London. 1992; 367-70.
  • Mızrak C, Yenice E, Can M, Yıldırım U, Atık Z. Effects of dietary boron on performance, egg production, egg quality and some bone parameters in layer hens. S Afr J Anim Sci 2010; 40(3): 257-64.
  • Miljkovic D, Natasha M, Mark MF. Up-regulatory impact of boron on vitamin D function-does it reflect inhibition of 24hydroylase. Med Hypotheses 2004; 63(6): 1054Moseman RF. Chemical disposition of boron in animals and humans. Environ Health Perspect. 1994; 102(Suppl 7): 113-7.
  • Naghii MR, Samman S. The effect of boron on plasma testosterone and plasma lipids in rats. Nutr Res 1997; 17(3): 523-31.
  • Naghii MR, Samman S. The role of boron in nutrition and metabolism. Prog Food Nutr Sci 1993; 17(4): 331-49.
  • Nielsen FH, Hunt CD, Mu LM, Hunt JR. Effect of boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1(5): 394-97.
  • Nielsen FH, Schuler TR, Zimmerman TJ, Uthus EO. Dietary magnesium, manganese and boron affect the response of rats to high dietary aluminium. Magnes 1988; 7(3): 133-47 (Abstr).
  • Nielsen FH, Schuler TR. Studies of the interaction between boron and calcium, and its modification by magnesium and potassium in rats. Effects on growth, blood variables, and bone mineral composition. Biol Trace Elem Res 1992; 35(3): 225-37 (Abstr).
  • Nielsen FH. Boron-an overlooked elements of potential nutritional importance. Nutr Today 1988; 4-7.
  • Nielsen FH. Dietary fat composition modifies the effect of boron on bone characteristics and plasma lipids in rats. Biofactors 2004; 20 (3): 161-71 (Abstr).
  • Pawa S, Ali S. Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact 2006; 160(2): 89-98.
  • Price CJ, Melissa CM, Myers CB, Seely JC, Heindel JJ, Schwetz BA. The developmental toxicity of boric acid in rabbits. Fundamental Appl Toxicol 1996; 34(2): 176-87.
  • Qin X, Klandorf H. Effect of dietary boron supplementation on egg production, shell quality, and calcium metabolism in aged broiler breeder hens. Poultry Sci 1991; 70(10): 2131
  • Rossi AF, Miles RD, Damron BL, Flunker LK. Effects of dietary boron supplementation on broilers. Poultry Sci 1993; 72(11): 2124-30.
  • Shaaban MM. Role of boron in plant nutrition and human health. Am J Plant Physiol 2010;
  • (5): 224-40.
  • Sisk DB, Colvin BM, Merrill A,Bondari K, Bowen JM. Experimental acute inorganic boron toxicosis in the goat: Effects on serum chemistry and CSF biogenic amines. Vet Hum Toxicol 1990; 32(3): 205-11.
  • Tariq M, Mott CJB. The significance of boron in plant nutrition and environment-A review. J Agron 2007; 6(1): 1-10.
  • Türkez H. Effects of boric acid and borax on titanium dioxide genotoxicity. J Appl Toxicol 2008; 28(5): 658-64.
  • WHO. Boron. International Programme on Chemical Safety. Environmental Health Criteria 204. Ohio, USA.1998; 1-201.
  • Wilson JH, Ruszler PL. Effects of dietary boron supplementation on laying hens. Br Poultry Sci 1996; 37(4): 723-29 (Abstr).
  • Wilson JH, Ruszler PL. Long term effects of boron on layer bone strength and production parameters. Br Poult Sci 1998; 39(1): 11-5.
  • Woods WG. An introduction to boron:history, sources, uses, and chemistry. Environ Health Perspect 1994; 102 (Suppl 7): 5-11.
  • Yeşilbağ D, Eren M. Effects of dietary boric acid supplementation of performance, egg shell quality and some serum parameters in aged laying hens. Turk J Vet Anim Sci 2008; 32(2):113-7.
There are 61 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

P. Yiğit This is me

M. Eren This is me

Z.s. Sarıca This is me

M. Şentürk This is me

Publication Date June 1, 2013
Submission Date June 24, 2014
Published in Issue Year 2013 Volume: 10 Issue: 2

Cite

APA Yiğit, P., Eren, M., Sarıca, Z., Şentürk, M. (2013). Tavşanlarda Borik Asidin Kan Kimyasına Etkisi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 10(2).
AMA Yiğit P, Eren M, Sarıca Z, Şentürk M. Tavşanlarda Borik Asidin Kan Kimyasına Etkisi. Erciyes Üniv Vet Fak Derg. June 2013;10(2).
Chicago Yiğit, P., M. Eren, Z.s. Sarıca, and M. Şentürk. “Tavşanlarda Borik Asidin Kan Kimyasına Etkisi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 10, no. 2 (June 2013).
EndNote Yiğit P, Eren M, Sarıca Z, Şentürk M (June 1, 2013) Tavşanlarda Borik Asidin Kan Kimyasına Etkisi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 10 2
IEEE P. Yiğit, M. Eren, Z. Sarıca, and M. Şentürk, “Tavşanlarda Borik Asidin Kan Kimyasına Etkisi”, Erciyes Üniv Vet Fak Derg, vol. 10, no. 2, 2013.
ISNAD Yiğit, P. et al. “Tavşanlarda Borik Asidin Kan Kimyasına Etkisi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 10/2 (June 2013).
JAMA Yiğit P, Eren M, Sarıca Z, Şentürk M. Tavşanlarda Borik Asidin Kan Kimyasına Etkisi. Erciyes Üniv Vet Fak Derg. 2013;10.
MLA Yiğit, P. et al. “Tavşanlarda Borik Asidin Kan Kimyasına Etkisi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, vol. 10, no. 2, 2013.
Vancouver Yiğit P, Eren M, Sarıca Z, Şentürk M. Tavşanlarda Borik Asidin Kan Kimyasına Etkisi. Erciyes Üniv Vet Fak Derg. 2013;10(2).
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