Study on defluoridation of water by using activated carbon derived from chestnut shell as adsorbent

Year 2024, Volume: 7 Issue: 4, 547 - 563, 31.12.2024

Firdous Ahmad Dar , Swamy Kurella

https://doi.org/10.35208/ert.1472406

Abstract

The present work intended to produce new cost-effective alkali-activated adsorbents from chestnut shells with the purpose of removing fluoride from water, and to explore the effect of pyrolysis temperature on fluoride decontamination at different operational and environmental parameters. The microstructure and morphological characteristics of the resulting activated carbons were thoroughly investigated using BET, FTIR, XRD and SEM. The effectiveness of the prepared adsorbent materials in treating and remediating fluorinated water was evaluated. The impacts of several factors, including the dose of the adsorbent, the initial contamination level of fluoride, and pH on the fluoride removal efficiency were investigated were investigated. In accordance with the data, the highest adsorption was found to be at a 6 pH during 5 hours of processing duration and 0.5 g/L of dosage of adsorbent. The experimental results were well-fit by the Freundlich isotherm model and the pseudo-second-order kinetic model. The highest fluoride removal efficiency was found to be 78% at adsorption medium pH 6 and initial fluoride concentration of 10mg/L by the adsorbent prepared at 800 °C. Additional research on adsorption along with rejuvenation revealed that the reduction in adsorption potential to 10% following four repetitions of operation involving regeneration, thereby showcasing the adsorbent's versatile applicability for repeated use.

Keywords

Activated Carbon, adsorption, characterization, fluoride, water remediation

References

• S. Arya, T. Subramani, G. Vennila, and D. Karunanidhi, “Health risks associated with fluoride intake from rural drinking water supply and inverse mass balance modeling to decipher hydrogeochemical processes in Vattamalaikarai River basin, South India,” Environmental Geochemistry and Health, Vol. 43, pp. 705–716, 2021. [CrossRef]
• S. Ahmadi, M. Mesbah, C.A. Igwegbe, C.D. Ezeliora, C. Osagie, N.A. Khan, G.L. Dotto, M. Salari, and M.H. Dehghani, Sono electro-chemical synthesis of LaFeO3nanoparticles for the removal of fluoride: Optimization and modeling using RSM, ANN and GA tools, Journal of Environmental Chemical Engineering, Vol. 9, Article 105320, 2021. [CrossRef]
• R.W. Premathilaka, and N.D. Liyanagedera, “Fluoride in drinking water and nanotechnological approaches for eliminating excess fluoride,” Journal of Nanotechnology, Vol. 2019, Article 2192383, 2019. [CrossRef]
• F. A. Dar, and S. Kurella, “Recent advances in adsorption techniques for fluoride removal – An overview,” Groundwater for Sustainable Development, Vol. 23, Article 101017, 2023. [CrossRef]
• F. Ahmad Dar, S. Kurella, Fluoride in drinking water: An in-depth analysis of its prevalence, health effects, advances in detection and treatment, Materials Today: Proceedings, 2023. [Epub ahead of print]. doi: 10.1016/j.matpr.2023.05.645. [CrossRef]
• G. Jacks, P. Bhattacharya, V. Chaudhary, and K. P. Singh, “Controls on the genesis of some high-fluoride groundwaters in India,” Applied Geochemistry, Vol. 20, pp. 221–228, 2005. [CrossRef]
• A.I. Ndé-Tchoupé, R. Tepong-Tsindé, M. Lufingo, Z. Pembe-Ali, I. Lugodisha, R.I. Mureth, M. Nkinda, J. Marwa, W. Gwenzi, T.B. Mwamila, M.A. Rahman, C. Noubactep, and K.N. Njau, “White teeth and healthy skeletons for all: The path to universal fluoride-free drinking water in Tanzania,” Water (Switzerland), Vol. 11, 2019. [CrossRef]
• K.K. Yadav, S. Kumar, Q.B. Pham, N. Gupta, S. Rezania, H. Kamyab, S. Yadav, J. Vymazal, V. Kumar, D.Q. Tri, A. Talaiekhozani, S. Prasad, L.M. Reece, N. Singh, P.K. Maurya, and J. Cho, “Fluoride contamination, health problems and remediation methods in Asian groundwater: A comprehensive review,” Ecotoxicology and Environmental Safety, Vol. 182, Article 109362, 2019. [CrossRef]
• S. Ali, S. Shekhar, P. Bhattacharya, G. Verma, T. Chandrasekhar, and A. K. Chandrashekhar, “Elevated fluoride in groundwater of Siwani Block, Western Haryana, India: A potential concern for sustainable water supplies for drinking and irrigation,” Groundwater for Sustainable Development, Vol. 7, pp. 410–420, 2018. [CrossRef]
• M. Vithanage, P. Bhattacharya, Fluoride in the environment: sources, distribution and defluoridation, Environmental Chemistry Letters. Vol. 13, pp. 131–147, 2015. [CrossRef]
• M. Vithanage, P. Bhattacharya, Fluoride in Drinking Water: Health Effects and Remediation, in: S. E., R. J. (Eds.), Lichtfouse, Springer, Environmental Chemistry for a Sustainable World: Volume 5: CO2 Sequestration, Biofuels and Depollution. International Publishing, Switzerland, pp. 105–151, 2015. [CrossRef]
• J. Ijumulana, F. Ligate, R. Irunde, P. Bhattacharya, J.P. Maity, A. Ahmad, and F. Mtalo, “Spatial uncertainties in fluoride levels and health risks in endemic fluorotic regions of northern Tanzania,” Groundwater for Sustainable Development, Vol. 14, Article 100618, 2021. [CrossRef]
• V. Kimambo, P. Bhattacharya, F. Mtalo, J. Mtamba, A. Ahmad, Fluoride occurrence in groundwater systems at global scale and status of defluoridation – State of the art, Groundwater for Sustainable Development, Vol. 9, Article 100223, 2019. [CrossRef]
• R.W. Herschy, Water quality for drinking: WHO guidelines, “Encyclopedia of Earth Sciences Series,” pp. 876–883, 2012. [CrossRef]
• A. K. Tolkou, N. Manousi, G.A. Zachariadis, I.A. Katsoyiannis, and E. A. Deliyanni, Recently developed adsorbing materials for fluoride removal from water and fluoride analytical determination techniques: A review,” Sustainability (Switzerland), Vol. 13, Article 7061, 2021. [CrossRef]
• A. Mohamed, E. P. Valadez Sanchez, E. Bogdanova, B. Bergfeldt, A. Mahmood, R. V. Ostvald, and T. Hashem, “Efficient fluoride removal from aqueous solution using zirconium-based composite nanofiber membranes,” Membranes, Vol. 11, pp. 113, 2021. [CrossRef]
• M. Grzegorzek, K. Majewska-Nowak, and A. E. Ahmed, “Removal of fluoride from multicomponent water solutions with the use of monovalent selective ion-exchange membranes,” Science of the Total Environment, Vol. 722, 2020. [CrossRef]
• A. K. Tolkou, M. Mitrakas, I. A. Katsoyiannis, M. Ernst, and A. I. Zouboulis, “Fluoride removal from water by composite Al/Fe/Si/Mg pre-polymerized coagulants: Characterization and application,” Chemosphere, Vol. 231, pp. 528–537, 2019. [CrossRef]
• Y. Wang, and E. J. Reardon, “Activation and regeneration of a soil sorbent for defluoridation of drinking water,” Applied Geochemistry, Vol. 16, pp. 531–539, 2001. [CrossRef]
• Y. Gan, X. Wang, L. Zhang, B. Wu, G. Zhang, S. Zhang, Coagulation removal of fluoride by zirconium tetrachloride: Performance evaluation and mechanism analysis, Chemosphere, Vol. 218, pp. 860–868, 2019. [CrossRef]
• K.K. Yadav, N. Gupta, V. Kumar, S.A. Khan, and A. Kumar, “A review of emerging adsorbents and current demand for defluoridation of water: Bright future in water sustainability,” Environment International, Vol. 111 pp. 80–108, 2018. [CrossRef]
• P. S. Kumar, S. Suganya, S. Srinivas, S. Priyadharshini, M. Karthika, R. Karishma Sri, V. Swetha, M. Naushad, and E. Lichtfouse, “Treatment of fluoride-contaminated water. A review,” Environmental Chemistry Letters, Vol. 17, pp. 1707–1726, 2019. [CrossRef]
• R. Kumar, S. Ali, S. Sandanayake, M.A. Islam, J. Ijumulana, J.P. Maity, M. Vithanage, M.A. Armienta, P. Sharma, R. Hamisi, V. Kimambo, and P. Bhattacharya, “Fluoride as a global groundwater contaminant,” in: R. Naidu (Ed.), Inorganic Contaminants and Radionuclides, Elsevier, pp. 319–350, 2023. [CrossRef]
• B. Van der Bruggen, M. Mänttäri, and M. Nyström, “Drawbacks of applying nanofiltration and how to avoid them: A review,” Separation and Purification Technology, Vol. 63, pp. 251–263, 2008. [CrossRef]
• Y. Du, D. Wang, W. Wang, J. Fu, X. Chen, L. Wang, W. Yang, and X. Zhang, “Electrospun Nanofibrous Polyphenylene Oxide Membranes for High-Salinity Water Desalination by Direct Contact Membrane Distillation,” ACS Sustainable Chemistry and Engineering,” Vol. 7, pp. 20060–20069, 2019. [CrossRef]
• S. Jagtap, M.K. Yenkie, N. Labhsetwar, and S. Rayalu, “Fluoride in drinking water and defluoridation of water,” Chemical Reviews, Vol. 112, pp. 2454–2466, 2012. [CrossRef]
• M. Sadhu, P. Bhattacharya, M. Vithanage, and P. Padmaja Sudhakar, “Adsorptive removal of fluoride using biochar – A potential application in drinking water treatment,” Separation and Purification Technology, Vol. 278, Article 119106, 2021. [CrossRef]
• M. M. Mahmoudi, S. Nasseri, A. H. Mahvi, A. Dargahi, M. S. Khubestani, and M. Salari, “Fluoride removal from aqueous solution by acid-treated clinoptilolite: Isotherm and kinetic study,” Desalination and Water Treatment, Vol. 146, pp. 333–340, 2019. [CrossRef]
• R. Kumar, P. Sharma, W. Yang, M. Sillanpää, J. Shang, P. Bhattacharya, M. Vithanage, and J. P. Maity, “State-of-the-art of research progress on adsorptive removal of fluoride-contaminated water using biochar-based materials: Practical feasibility through reusability and column transport studies,” Environmental Research, Vol. 214, Article 114043, 2022. [CrossRef]
• M. T. Samadi, M. Zarrabi, M.N. Sepehr, S. M. Ramhormozi, S. Azizian, and A. Amrane, “Removal of fluoride ions by ion exchange resin: Kinetic and equilibrium studies,” Environmental Engineering and Management Journal, Vol. 13, pp. 205–214, 2014. [CrossRef]
• T. Pang, T. S. Aye Chan, Y.A.C. Jande, and J. Shen, “Removal of fluoride from water using activated carbon fibres modified with zirconium by a drop-coating method,” Chemosphere, Vol. 255, Article 126950, 2020. [CrossRef]
• R. Kumar, P. Sharma, P.K. Rose, P.K. Sahoo, P. Bhattacharya, A. Pandey, and M. Kumar, “Co-transport and deposition of fluoride using rice husk-derived biochar in saturated porous media: Effect of solution chemistry and surface properties,” Environmental Technology and Innovation, Vol. 30, Article 103056, 2023. [CrossRef]
• M. Tazik, M.H. Dehghani, K. Yaghmaeian, S. Nazmara, M. Salari, A.H. Mahvi, S. Nasseri, H. Soleimani, and R.R. Karri, “4-Chlorophenol adsorption from water solutions by activated carbon functionalized with amine groups: response surface method and artificial neural networks,” Scientific Reports, Vol. 13, pp. 1–20, 2023. [CrossRef]
• H.M. Duong, T.Q. Tran, R. Kopp, S.M. Myint, and L. Peng, “Direct spinning of horizontally aligned carbon nanotube fibers and films from the floating catalyst method,” Elsevier, Inc, 2019.
• H. M. Duong, S. M. Myint, T. Q. Tran, and D. K. Le, “Post-spinning treatments to carbon nanotube fibers,” Elsevier, Ltd, 2019. [CrossRef]
• L. Delgadillo-Velasco, V. Hernández-Montoya, F.J. Cervantes, M. A. Montes-Morán, and D. Lira-Berlanga, “Bone char with antibacterial properties for fluoride removal: Preparation, characterization and water treatment,” Journal of Environmental Management, Vol. 201, pp. 277–285, 2017.
• J. Chen, R. Yang, Z. Zhang, and D. Wu, “Removal of fluoride from water using aluminum hydroxide-loaded zeolite synthesized from coal fly ash,” Journal of Hazardous Materials, Vol. 421, Article 126817, 2022. [CrossRef]
• N. Nabbou, M. Belhachemi, M. Boumelik, T. Merzougui, D. Lahcene, Y. Harek, A.A. Zorpas, and M. Jeguirim, “Removal of fluoride from groundwater using natural clay (kaolinite): Optimization of adsorption conditions,” Comptes Rendus Chimie, Vol. 22, pp. 105–112, 2019. [CrossRef]
• G.Z. Kyzas, A.K. Tolkou, T.J. Al Musawi, N. Mengelizadeh, S. Mohebi, and D. Balarak, “Fluoride removal from water by using green magnetic activated carbon derived from canola stalks,” Water, Air, and Soil Pollution, Vol. 233, 2022. [CrossRef]
• E. Vences-Alvarez, J. L. Flores-Arciniega, H. Flores-Zuñiga, and J. R. Rangel-Mendez, “Fluoride removal from water by ceramic oxides from cerium and manganese solutions,” Journal of Molecular Liquids, Vol. 286, Article 11088, 2019. [CrossRef]
• A. K. Chaturvedi, K. C. Pathak, and V. N. Singh, “Fluoride removal from water by adsorption on china clay,” Applied Clay Science, Vol. 3, pp. 337–346, 1988. [CrossRef]
• P. Pillai, S. Dharaskar, M. Shah, and R. Sultania, “Determination of fluoride removal using silica nano adsorbent modified by rice husk from water,” Groundwater for Sustainable Development, Vol. 11, Article 10042, 2020. [CrossRef]
• R. R. Devi, I. M. Umlong, P. K. Raul, B. Das, S. Banerjee, and L. “Singh, Defluoridation of water using nano-magnesium oxide,” Journal of Experimental Nanoscience, Vol. 9, pp. 512–524, 2014. [CrossRef]
• J. Zhou, W. Zhu, J. Yu, H. Zhang, Y. Zhang, X. Lin, and X. Luo, “Highly selective and efficient removal of fluoride from ground water by layered Al-Zr-La Tri-metal hydroxide,” Applied Surface Science, Vol. 435, pp. 920–927, 2018. [CrossRef]
• N. Zhou, X. Guo, C. Ye, L. Yan, W. Gu, X. Wu, Q. Zhou, Y. Yang, X. Wang, and Q. Cheng, “Enhanced fluoride removal from drinking water in wide pH range using La/Fe/Al oxides loaded rice straw biochar,” Water Supply, Vol. 22, pp. 779–794, 2022. [CrossRef]
• A. Amalraj, and A. Pius, “Removal of fluoride from drinking water using aluminum hydroxide coated activated carbon prepared from bark of Morinda tinctoria,” Applied Water Science, Vol. 7, pp. 2653–2665, 2017. [CrossRef]
• C. E. Choong, K.T. Wong, S. B. Jang, I. W. Nah, J. Choi, S. Ibrahim, Y. Yoon, and M. Jang, “Fluoride removal by palm shell waste based powdered activated carbon vs. functionalized carbon with magnesium silicate: Implications for their application in water treatment,” Chemosphere, Vol. 239, Article 124765, 2020. [CrossRef]
• N. Minju, K. Venkat Swaroop, K. Haribabu, V. Sivasubramanian, and P. Senthil Kumar, “Removal of fluoride from aqueous media by magnesium oxide-coated nanoparticles,” Desalination and Water Treatment, Vol. 53, pp. 2905–2914, 2015. [CrossRef]
• P. Wu, L. Xia, Y. Liu, J. Wu, Q. Chen, and S. Song, “Simultaneous sorption of arsenate and fluoride on calcined Mg-Fe-La hydrotalcite-like compound from water,” ACS Sustainable Chemistry and Engineering, Vol. 6, pp. 16287–16297, 2018. [CrossRef]
• A. K. Tolkou, S. Trikalioti, O. Makrogianni, D. G. Trikkaliotis, E. A. Deliyanni, G. Z. Kyzas, and I. A. Katsoyiannis, “Magnesium modified activated carbons derived from coconut shells for the removal of fluoride from water,” Sustainable Chemistry and Pharmacy, Vol. 31, Article 100898, 2023. [CrossRef]
• L. X. Li, D. Xu, X .Q. Li, W. C. Liu, and Y. Jia, “Excellent fluoride removal properties of porous hollow MgO microspheres,” New Journal of Chemistry, Vol. 38, pp. 5445–5452, 2014. [CrossRef]
• C. Sairam Sundaram, N. Viswanathan, S. Meenakshi, Defluoridation of water using magnesia/chitosan composite, Journal of Hazardous Materials, Vol. 163, pp. 618–624, 2009. [CrossRef]
• S. A. Mousavi, B. Kamarehie, A. Almasi, M. Darvishmotevalli, M. Salari, M. Moradnia, F. Azimi, M. Ghaderpoori, Z. Neyazi, and M. A. Karami, “Removal of Rhodamine B from aqueous solution by stalk corn activated carbon: adsorption and kinetic study,” Biomass Conversion and Biorefinery, Vol. 13, pp. 7927–7936, 2023. [CrossRef]
• A. Alahabadi, N. Shomoossi, F. Riahimanesh, and M. Salari, “Development of AC/ZnO/Fe2O3 for efficiently adsorptive removal of Tetracycline from water environment: isotherm, kinetic and thermodynamic studies and adsorption mechanism,” Biomass Conversion and Biorefinery, Vol. 14, pp. 17499–17517, 2023. [CrossRef]
• B. Devi, N.P. Baruah, A. Bharadwaj, and A. Devi, “Adsorptive removal of fluoride ions from aqueous solution using activated carbon supported tetrametallic oxide system,” Chemical Engineering Research and Design, Vol. 197, pp. 380–391, 2023. [CrossRef]
• D. Cheng, H.H. Ngo, W. Guo, S.W. Chang, D.D. Nguyen, X. Zhang, S. Varjani, and Y. Liu, “Feasibility study on a new pomelo peel derived biochar for tetracycline antibiotics removal in swine wastewater,” Science of the Total Environment, Vol. 720 Article 137662, 2020. [CrossRef]
• H. Zhou, X. Li, H. Jin, and D. She, “Mechanism of a double-channel nitrogen-doped lignin-based carbon on the highly selective removal of tetracycline from water,” Bioresource Technology, Vol. 346, Article 126652, 2022. [CrossRef]
• M. Wei, F. Marrakchi, C. Yuan, X. Cheng, D. Jiang, F.F. Zafar, Y. Fu, S. Wang, Adsorption modeling, thermodynamics, and DFT simulation of tetracycline onto mesoporous and high-surface-area NaOH-activated macroalgae carbon, Journal of Hazardous Materials, Vol. 425, Article 12788, 2022. [CrossRef]
• J. Qu, X. Lin, Z. Liu, Y. Liu, Z. Wang, S. Liu, Q. Meng, Y. Tao, Q. Hu, and Y. Zhang, “One-pot synthesis of Ca-based magnetic hydrochar derived from consecutive hydrothermal and pyrolysis processing of bamboo for high-performance scavenging of Pb(Ⅱ) and tetracycline from water,” Bioresource Technology, Vol. 343 Article 126046, 2022.
• H. Zhang, X. Song, J. Zhang, Y. Liu, H. Zhao, J. Hu, and J. Zhao, “Performance and mechanism of sycamore flock based biochar in removing oxytetracycline hydrochloride,” Bioresource Technology, Vol. 350 Article 126884, 2022. [CrossRef]
• J. E. Kim, S. K. Bhatia, H. J. Song, E. Yoo, H. J. Jeon, J. Y. Yoon, Y. Yang, R. Gurav, Y. H. Yang, H. J. Kim, and Y. K. Choi, “Adsorptive removal of tetracycline from aqueous solution by maple leaf-derived biochar,” Bioresource Technology, Vol. 306, Article 123092, 2020. [CrossRef]
• W. Bae, J. Kim, and J. Chung, “Production of granular activated carbon from food-processing wastes (walnut shells and jujube seeds) and its adsorptive properties,” Journal of the Air and Waste Management Association, Vol. 64, pp. 879–886, 2014. [CrossRef]
• S. Cheng, L. Zhang, H. Xia, J. Peng, S. Zhang, and S. Wang, “Preparation of high specific surface area activated carbon from walnut shells by microwave-induced KOH activation,” Journal of Porous Materials, Vol. 22, pp. 1527–1537, 2015. [CrossRef]
• B. Li, Y. Zhang, J. Xu, Y. Mei, S. Fan, and H. Xu, “Effect of carbonization methods on the properties of tea waste biochars and their application in tetracycline removal from aqueous solutions,” Chemosphere, Vol. 267, Article 129283, 2021. [CrossRef]
• K. Zhu, Y. Duan, F. Wang, P. Gao, H. Jia, C. Ma, and C. Wang, “Silane-modified halloysite/Fe3O4nanocomposites: Simultaneous removal of Cr(VI) and Sb(V) and positive effects of Cr(VI) on Sb(V) adsorption,” Chemical Engineering Journal, Vol. 311, pp. 236–246, 2017.
• M. Zhang, L. Xu, C. Qi, and M. Zhang, “Highly effective removal of tetracycline from water by hierarchical porous carbon: Batch and column adsorption,” Industrial and Engineering Chemistry Research, Vol. 58, pp. 20036–20046, 2019. [CrossRef]
• J. Zhang, M. Lu, J. Wan, Y. Sun, H. Lan, and X. Deng, “Effects of pH, dissolved humic acid and Cu2+ on the adsorption of norfloxacin on montmorillonite-biochar composite derived from wheat straw,” Biochemical Engineering Journal, Vol. 130, 104–112, 2018. [CrossRef]
• S. Kalita, M. Pathak, G. Devi, H.P. Sarma, K.G. Bhattacharyya, A. Sarma, and A. Devi, “Utilization of: Euryale ferox Salisbury seed shell for removal of basic fuchsin dye from water: Equilibrium and kinetics investigation,” RSC Advances, Vol. 7, pp. 27248–27259, 2017. [CrossRef]
• L. Huang, Z. Yang, Z. Zhang, L. Jin, W. Yang, Y. He, L. Ren, and H. Wang, “Enhanced surface hydroxyl groups by using hydrogen peroxide on hollow tubular alumina for removing fluoride,” Microporous and Mesoporous Materials, Vol. 297, Article 110051, 2020. [CrossRef]
• P. Dhanasekaran, O. Sahu, Arsenate and fluoride removal from groundwater by sawdust impregnated ferric hydroxide and activated alumina (SFAA), Groundwater for Sustainable Development. Vol. 12, Article 100490, 2021. [CrossRef]
• M. Mouelhi, S. Giraudet, A. Amrane, B. Hamrouni, Competitive adsorption of fluoride and natural organic matter onto activated alumina, Environmental Technology (United Kingdom),” Vol. 37, pp. 2326–2336, 2016. [CrossRef]
• S. Wu, K. Zhang, J. He, X. Cai, K. Chen, Y. Li, B. Sun, L. Kong, and J. Liu, “High efficient removal of fluoride from aqueous solution by a novel hydroxyl aluminum oxalate adsorbent,” Journal of Colloid and Interface Science, Vol. 464, pp. 238–245, 2016. [CrossRef]
• S.K. Swain, T. Patnaik, V.K. Singh, U. Jha, R.K. Patel, and R. K. Dey, “Kinetics, equilibrium and thermodynamic aspects of removal of fluoride from drinking water using meso-structured zirconium phosphate,” Chemical Engineering Journal, Vol. 171, pp. 1218–1226, 2011. [CrossRef]
• J. Wang, N. Chen, C. Feng, and M. Li, “Performance and mechanism of fluoride adsorption from groundwater by lanthanum-modified pomelo peel biochar,” Environmental Science and Pollution Research, Vol. 25, pp. 15326–15335, 2018. [CrossRef]
• W. Kim, R. Singh, and J. A. Smith, “Modified crushed oyster shells for fluoride removal from water,” Scientific Reports, Vol. 10, pp. 1–13, 2020. [CrossRef]
• J. I. Lee, J. K. Kang, S. H. Hong, C. G. Lee, S. Jeong, and S. J. Park, “Thermally treated Mytilus coruscus shells for fluoride removal and their adsorption mechanism,” Chemosphere, Vol. 263, Article 128328, 2021. [CrossRef]