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CURRENT APPROACHES IN MULTIPLE SCLEROSIS NUTRITION TREATMENT

Year 2021, Volume: 8 Issue: 2, 48 - 58, 30.12.2021

Abstract

In Multiple Sclerosis (MS), an autoimmune disease affecting the central nervous system, genetic and environmental factors affect individuals at different rates. Recently, it has been determined that there is a higher tendency towards complementary alternative therapies such as vitamin supplementation in the treatment of MS. Ketogenic diet, McDougall diet, intermittent fasting, paleolithic diet, Swank diet are applied to MS patients and researches are conducted on their effects. Preserving the intestinal microbiota and giving priority to anti-inflammatory foods and eliminating some foods that are predicted to cause damage in the body have an important place in the nutritional treatment of MS. Although there is no specific gluten-free diet, the Wahls elimination diet aims to prevent the possibility of promoting the inflammatory process in the body. It has been shown that both mental and physical health conditions of patients who are added nutritional therapy to their treatment have improved. In this review, it is aimed to share current approaches in nutritional therapy against MS disease.

References

  • Choi IY, Piccio L, Childress P, et al. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptom. Cell Rep 2016; 15: 2136–2146.
  • Wu H., Zhao M, Yoshimura A, et al. Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review, US National Library of Medicine 2016; 50(3): 333-344.
  • Dos Passos GR, Sato DK, Becker J, et al. Th17 Cells Pathways in Multiple Sclerosis and NeuromyelitisOptica Spectrum Disorders: Pathophysiological and Therapeutic Implications. Mediators Inflamm 2016; 5: 314-541.
  • Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and Multiple Sclerosis: An update. Mult Scler. HAL archives-ouvertes, 2017;14: 35-45.
  • Ulucan Karnak F. Multiple Skleroz Hastalığına Karşı Tedavi Yaklaşımları. ERÜ Sağlık Bilimleri Fakültesi Dergisi 2020; 7(2): 49-54.
  • Wahls TL. The Seventy Percent Solution. J. Gen. Intern. Med 2011; 26: 1215–1216. Berer K, Kristnamoorthy G. Microbial View of Central Nervous System Autoimmunity. Febs Letters 2014; 588: 4207-4213.
  • Irish A, Erickson C, Wahls T, et al. Randomized Control Trial Evaluation of a Modified Paleolithic Dietary İntervention in the Treatment of Relapsing-Remitting Multiple Sclerosis: a Pilot Study. Degenerative Neurological and Neuromuscular Disease Journal 2016; 7: 1-18.
  • Duru Aşiret G, Düğer Ü, Kapucu S, et al. Multiple Skleroz Hastalarının Tamamlayıcı ve Alternatif Tedavi Kullanım Durumlarının Belirlenmesi. GÜSBD 2017; 6(3): 1 – 6.
  • Hay MC, Strathmann C, Lieber E, et al. Why patients go online: multiple sclerosis, the internet, and physician-patient communication. US National Library of Medicine 2008. ;14(6):374-81.
  • Piccio L, Stark JL, Cross AH. Chronic Calorie Restriction Attenuates Experimental Autoimmune Encephalomyelitis. Journal of Leukocyte Biology 2008; 84:940-948.
  • Von Geldern G, Mowry EM. The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol 2012; 8: 678–689.
  • Evans E, Piccio L, Cross AH. Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis. JAMA Neurol 2018;75(8):1013-1021.
  • Bagur MJ, Murcia MA, Jiménez-Monreal AM, et al. Influence of Diet in Multiple Sclerosis: A Systematic Review. Advances in Nutrition 2017; 8(3):463–472.
  • Waslo C, Bourdette D, Gray N, et al. Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis. Curr Treat Options Neurol 2019; 21(26): 1-21.
  • Riccio P, Rossano R. Nutrition Facts in Multiple Sclerosis. ASN Neuro 2015; 1–20.
  • Riccio P, Rossano R. Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis. Neurotherapeutics 2018; 15:75–91.
  • Yadav V, Shinto L, Bourdette D. Complementary and alternative medicine for the treatment of multiple sclerosis. Expert Review of Clinical Immunology 2014; 6(3): 381-395.
  • Perez-Muñoz ME, Sugden S, Harmsen HJM, et al. Nutritional and ecological perspectives of the interrelationships between diet and the gut microbiome in multiple sclerosis: Insights from marmosets. iScience 2021; 24: 1-25.
  • Timmermans S, Bogie J FJ, Vanmierlo T, et al. High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System. Journal of Neuroimmune Pharmacology 2014; 9:209-217.
  • Bruce JM, Cozart JS, Shook RP, et al. Modifying Diet and Exercise in MS (MoDEMS): Study design and protocol for a telehealth weight loss intervention for adults with obesity & Multiple Sclerosis. Contemporary Clinical Trials 2021;107:1-8.
  • Devorak J, Mokry LE, Morris JA, et al. Large differences in adiponectin levels have no clear effect on multiple sclerosis risk: A Mendelian randomization study. Multiple Sclerosis Journal 2017; 23(11): 1461–1468.
  • Swank RL, Goodwin J. Review of MS Patient Survival on a Swank Low Saturated Fat Diet. Nutrition 2003; 19: 161–162.
  • Demir A, Yıldız E. Multiple Skleroz ve Beslenme. Ortadoğu Medical Journal 2015; 7(3): 144-148.
  • Hadgkiss E, Jelinek G, Weiland T, et al. The Association of Diet With Quality of Life, Disability, and Relapse Rate in an İnternational Sample of People with Multiple Sclerosis. Nutritional Neuroscience 2014; 18(3):125-136.
  • Souissi A, Mrabet S, Larnaout F, et al. Diet quality and multiple sclerosis severity: Is there a link?. Journal of the Neurological Sciences 2019; 405(15): 274-275.
  • Albrechtsen MT, Langeskov-Christensen M, Jørgensen MLK et al. Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? –Results from a pilot study. Multiple Sclerosis and Related Disorders 2020;40: 1-7.
  • Abdollahpour I,Jakimovski D, Shivappa N, et al. Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study. Clinical Nutrition 2020; 39(11): Pages 3402-3407.
  • Evans E, Levasseur V, Cross AH, et al. An overview of the current state of evidence for the role of specific diets in multiple sclerosis. Multiple Sclerosis and Related Disorders 2019; 36: 1-6.
  • Wahls TL, Chenard CA, Snetselaar LG. Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic. Nutrients 2019; 11( 352): 1-32.
  • Bisht B, Darling WG, Grossmann RE, et al. A Multimodal Intervention for Patients with Secondary Progressive Multiple Sclerosis: Feasibility and Effect on Fatigue. The Journal of Alternative and Complementary Medicine 2014; 20(5): 347-355.
  • Cordain L.. The Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups. J Am Neutraceut Assoc 2002; 5: 15-24.
  • Cordain L, Eaton SB, Sebastian A, et al. Origins and Evolution of the Western Diet:Health Implicatiıns fort he 21st Century. Am J Clin Nutr 2005; 81(2): 341-354.
  • Reese D, Shivapour ET, Wahls TL, et al. Neuromuscular Electrical Stimulation and Dietary İnterventions to Reduce Oxidative Stress in a Secondary Progressive Multiple Sclerosis Patient Leads to Marked Gains in Function: A Case report. Cases Journal 2009; 2: 1-4.
  • Masullo L, Papas MA, Cotunga N, et al. Complementary and Alternative Medicine Use and Nutrient Intake Among Individuals With Multiple Sclerosis in the United States. Journal of Community Health, 2015; 40: 153-160.
  • Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev 2015; 73(10): 661-674.
  • Aydoğdu GS, Akulut G. Aralıklı Açlık Diyetleri ve Düşük Karbonhidratlı Diyetlerin Obezite Tedavisindeki Etkisi. Bes Diy Derg 2020; 48(1),:98-106.
  • Kalaycı Z, Altun Kamarlı H. Aralıklı Açlık Diyetlerinin Glukoz Homeostazı ve Lipit Metabolizması Üzerine Etkileri. BANÜ Sağlık Bilimleri ve Araştırma Dergisi 2021; 3(1): 53-63.
  • Pani G. Neuroprotective effects of Dietary Restriction: Evidence and Mechanisms. Science Direct 2015; 40: 106-114.
  • Bai M, Wang Y, Han R, et al. Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis. The Journal of Nutritional Biochemistry 2021;87: 1-9.
  • Mattson MP, Longo VD, Harvie M. Impact of İntermittent Fasting on Health and Disease Processes. Science Direct 2017;39: 46-58.
  • Most J, Tosti V, Redman LM, et al. Calorie Restriction in Humans: an Update. Ageing Research Reviews 2017; 39: 36-45.
  • Roman SN, Fitzgerald KC, Beier M, et al. Safety and feasibility of various fasting-mimicking diets among people with multiple sclerosis. Multiple Sclerosis and Related Disorders 2020; 42:1-7.
  • Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 2009; 50: 304-317.
  • Pinto A, Bonucci A, Maggi E, et al. Anti-Oxidant and Antiinflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Diseas. Antioxidants 2018; 7(5): 1-16.
  • Kim DY, Hao J, Liu R, et al. Inflammationmediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis. Plos One 2012; 7(5):1-8.
  • McDonald TJW, Cervenka MC. Ketogenic Diets for Adult Neurological Disorders. Neurotherapeutics 2018;15(4): 1018-1031.
  • Barañano KW, Hartman AL. The Ketogenic Diet: Uses in Epilepsy and Other Neurologic Illnesses. Current Treatment Options in Neurology 2008, 10: 410– 419.
  • Mowry EM, Azevedo CJ, McCulloch CE, et al. Body Mass İndex, but not Vitamin D Status, is Associated With Brain Volume Change in MS. Neurology 2018; 91(24): 2256-2264.
  • Schüpbach R, Wegmüller R, Berguerand C, et al. Micronutrient Status and İntake in Omnivores, Vegetarians and Vegans in Switzerland. Eur. J. Nutr 2017; 56(1): 283–293.
  • McDougall, J, Thomas LE, McDougall C, et al. Effects of 7 Days on an ad Libitum Low-fat Vegan Diet: the McDougall Program cohort. Nutr J 2014;13(99): 1-7.
  • Mente A, Koning L, Shannon H. A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease. Arch Intern Med 2009; 169(7): 659-669.
  • Milijkoviç D, Dekanski D, Milijkoviç M., et al. Dry Olive Leaf Extract Ameliorates Experimental Autoimmune Encephalomyelitis. Clinical Nutrition 2009; 28(3): 346-350.
  • Sedaghat F, Jessri M, Behrooz M, et al. Mediterranean Diet Adherence and Risk of Multiple Sclerosis: a Case-control Study. Asia Pacific Journal of Clinical Nutrition, 2016; 25(2): 377-384.
  • Esposito S, Sparaco M, et al. Lifestyle and Mediterranean diet adherence in a cohort of Southern Italian patients with Multiple Sclerosis. Multiple Sclerosis and Related Disorders 2021; 47: 1-8.
  • Thomsen HL, Jessen EB, Passali M, et al. The role of Gluten in Multiple Sclerosis: A Systematic Review. Multiple Sklerosis and Related Disorders 2019; 27: 156-163.
  • Passali M, Josefsen K, Frederiksen JL, et al. Current Evidence on the Efficacy of Gluten-Free Diets in Multiple Sclerosis, Psoriasis, Type 1 Diabetes and Autoimmune Thyroid Diseases. Nutrients 2020;12(8):1-26.
  • Ben-Ami Shor D, Barzilai O, Ram M, et al. Gluten sensitivity in multiple sclerosis: experimental myth or clinical truth?. Ann N Y Acad Sci 2009 ;1173:343-349.
  • Raehsler SL, Choung RS, Marietta EV, et al. Accumulation of Heavy Metals in People on a Gluten-Free Diet. Clinical Gastroenterology and Hepatology 2018;1: 244–251.
  • Özkarabulut A, Onur H, Yaşar İ. Multiple Skleroz (MS) Hastalığı Öncesi ve Sonrası Beslenme Alışkanlıklarının Karşılaştırılması, Yeterli ve Dengeli Beslenmenin MS Ataklarına Olan Etkisinin İrdelenmesi. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi 2018; 6:535-550.
  • Fitzgerald KC, Munger KL, Kochert K, et al. Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b. JAMA Neurolgy 2015; 72(12): 1458-1465.
  • Harbige LS, Sharief MK. Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. British Journal of Nutrition 2007; 98(1):46–53.
  • Wilck N, Matus MG, Kearney SM, et al. Salt-Responsive Gut Commensal Modulates TH17 Axis and Disease. Nature 2017; 551: 585-589.
  • Kleinewietfeld M, Manzel A, Titze J, et al. Sodium Chloride Drives Autoimmune Disease by the İnduction of Pathogenic TH17 cells. Nature 2013; 496: 518-522.

MULTİPLE SKLEROZ BESLENME TEDAVİSİNDE GÜNCEL YAKLAŞIMLAR

Year 2021, Volume: 8 Issue: 2, 48 - 58, 30.12.2021

Abstract

Merkezi sinir sistemini etkileyen ve otoimmün bir hastalık olan Multiple Skleroz (MS) da genetik ve çevresel faktörler bireyleri etkilemektedir. Son zamanlarda MS tedavisinde vitamin desteği gibi tamamlayıcı alternatif tedavilere eğilimin daha yüksek olduğu saptanmıştır . MS hastalarına ketojenik diyet, Mcdougall diyeti, aralıklı oruç, paleolitik diyet, Swank diyeti uygulanmakta ve etkileri üzerine araştırmalar yapılmaktadır. Bağırsak mikrobiyotasını korumak ve antiinflamatuar besinlere öncelik verilip vücutta hasar bırakabilmesi öngörülen bazı besinlerin elimine edilmesi MS‘in beslenme tedavisinde önemli bir yer tutmaktadır. Spesifik bir glutensiz diyet uygulaması olmasa da Wahls eliminasyon diyeti vücutta inflamutuar süreci ilerletebilecek olasılıkları engellemeyi hedeflemektedir Tedavilerine beslenme tedavisi de eklenen hastaların hem zihinsel hem de fiziksel sağlık durumlarının iyileştiği gösterilmiştir. Bu derlemede, MS hastalığına karşı beslenme tedavisindeki güncel yaklaşımların paylaşılması amaçlanmıştır.

References

  • Choi IY, Piccio L, Childress P, et al. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptom. Cell Rep 2016; 15: 2136–2146.
  • Wu H., Zhao M, Yoshimura A, et al. Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review, US National Library of Medicine 2016; 50(3): 333-344.
  • Dos Passos GR, Sato DK, Becker J, et al. Th17 Cells Pathways in Multiple Sclerosis and NeuromyelitisOptica Spectrum Disorders: Pathophysiological and Therapeutic Implications. Mediators Inflamm 2016; 5: 314-541.
  • Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and Multiple Sclerosis: An update. Mult Scler. HAL archives-ouvertes, 2017;14: 35-45.
  • Ulucan Karnak F. Multiple Skleroz Hastalığına Karşı Tedavi Yaklaşımları. ERÜ Sağlık Bilimleri Fakültesi Dergisi 2020; 7(2): 49-54.
  • Wahls TL. The Seventy Percent Solution. J. Gen. Intern. Med 2011; 26: 1215–1216. Berer K, Kristnamoorthy G. Microbial View of Central Nervous System Autoimmunity. Febs Letters 2014; 588: 4207-4213.
  • Irish A, Erickson C, Wahls T, et al. Randomized Control Trial Evaluation of a Modified Paleolithic Dietary İntervention in the Treatment of Relapsing-Remitting Multiple Sclerosis: a Pilot Study. Degenerative Neurological and Neuromuscular Disease Journal 2016; 7: 1-18.
  • Duru Aşiret G, Düğer Ü, Kapucu S, et al. Multiple Skleroz Hastalarının Tamamlayıcı ve Alternatif Tedavi Kullanım Durumlarının Belirlenmesi. GÜSBD 2017; 6(3): 1 – 6.
  • Hay MC, Strathmann C, Lieber E, et al. Why patients go online: multiple sclerosis, the internet, and physician-patient communication. US National Library of Medicine 2008. ;14(6):374-81.
  • Piccio L, Stark JL, Cross AH. Chronic Calorie Restriction Attenuates Experimental Autoimmune Encephalomyelitis. Journal of Leukocyte Biology 2008; 84:940-948.
  • Von Geldern G, Mowry EM. The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol 2012; 8: 678–689.
  • Evans E, Piccio L, Cross AH. Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis. JAMA Neurol 2018;75(8):1013-1021.
  • Bagur MJ, Murcia MA, Jiménez-Monreal AM, et al. Influence of Diet in Multiple Sclerosis: A Systematic Review. Advances in Nutrition 2017; 8(3):463–472.
  • Waslo C, Bourdette D, Gray N, et al. Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis. Curr Treat Options Neurol 2019; 21(26): 1-21.
  • Riccio P, Rossano R. Nutrition Facts in Multiple Sclerosis. ASN Neuro 2015; 1–20.
  • Riccio P, Rossano R. Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis. Neurotherapeutics 2018; 15:75–91.
  • Yadav V, Shinto L, Bourdette D. Complementary and alternative medicine for the treatment of multiple sclerosis. Expert Review of Clinical Immunology 2014; 6(3): 381-395.
  • Perez-Muñoz ME, Sugden S, Harmsen HJM, et al. Nutritional and ecological perspectives of the interrelationships between diet and the gut microbiome in multiple sclerosis: Insights from marmosets. iScience 2021; 24: 1-25.
  • Timmermans S, Bogie J FJ, Vanmierlo T, et al. High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System. Journal of Neuroimmune Pharmacology 2014; 9:209-217.
  • Bruce JM, Cozart JS, Shook RP, et al. Modifying Diet and Exercise in MS (MoDEMS): Study design and protocol for a telehealth weight loss intervention for adults with obesity & Multiple Sclerosis. Contemporary Clinical Trials 2021;107:1-8.
  • Devorak J, Mokry LE, Morris JA, et al. Large differences in adiponectin levels have no clear effect on multiple sclerosis risk: A Mendelian randomization study. Multiple Sclerosis Journal 2017; 23(11): 1461–1468.
  • Swank RL, Goodwin J. Review of MS Patient Survival on a Swank Low Saturated Fat Diet. Nutrition 2003; 19: 161–162.
  • Demir A, Yıldız E. Multiple Skleroz ve Beslenme. Ortadoğu Medical Journal 2015; 7(3): 144-148.
  • Hadgkiss E, Jelinek G, Weiland T, et al. The Association of Diet With Quality of Life, Disability, and Relapse Rate in an İnternational Sample of People with Multiple Sclerosis. Nutritional Neuroscience 2014; 18(3):125-136.
  • Souissi A, Mrabet S, Larnaout F, et al. Diet quality and multiple sclerosis severity: Is there a link?. Journal of the Neurological Sciences 2019; 405(15): 274-275.
  • Albrechtsen MT, Langeskov-Christensen M, Jørgensen MLK et al. Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? –Results from a pilot study. Multiple Sclerosis and Related Disorders 2020;40: 1-7.
  • Abdollahpour I,Jakimovski D, Shivappa N, et al. Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study. Clinical Nutrition 2020; 39(11): Pages 3402-3407.
  • Evans E, Levasseur V, Cross AH, et al. An overview of the current state of evidence for the role of specific diets in multiple sclerosis. Multiple Sclerosis and Related Disorders 2019; 36: 1-6.
  • Wahls TL, Chenard CA, Snetselaar LG. Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic. Nutrients 2019; 11( 352): 1-32.
  • Bisht B, Darling WG, Grossmann RE, et al. A Multimodal Intervention for Patients with Secondary Progressive Multiple Sclerosis: Feasibility and Effect on Fatigue. The Journal of Alternative and Complementary Medicine 2014; 20(5): 347-355.
  • Cordain L.. The Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups. J Am Neutraceut Assoc 2002; 5: 15-24.
  • Cordain L, Eaton SB, Sebastian A, et al. Origins and Evolution of the Western Diet:Health Implicatiıns fort he 21st Century. Am J Clin Nutr 2005; 81(2): 341-354.
  • Reese D, Shivapour ET, Wahls TL, et al. Neuromuscular Electrical Stimulation and Dietary İnterventions to Reduce Oxidative Stress in a Secondary Progressive Multiple Sclerosis Patient Leads to Marked Gains in Function: A Case report. Cases Journal 2009; 2: 1-4.
  • Masullo L, Papas MA, Cotunga N, et al. Complementary and Alternative Medicine Use and Nutrient Intake Among Individuals With Multiple Sclerosis in the United States. Journal of Community Health, 2015; 40: 153-160.
  • Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev 2015; 73(10): 661-674.
  • Aydoğdu GS, Akulut G. Aralıklı Açlık Diyetleri ve Düşük Karbonhidratlı Diyetlerin Obezite Tedavisindeki Etkisi. Bes Diy Derg 2020; 48(1),:98-106.
  • Kalaycı Z, Altun Kamarlı H. Aralıklı Açlık Diyetlerinin Glukoz Homeostazı ve Lipit Metabolizması Üzerine Etkileri. BANÜ Sağlık Bilimleri ve Araştırma Dergisi 2021; 3(1): 53-63.
  • Pani G. Neuroprotective effects of Dietary Restriction: Evidence and Mechanisms. Science Direct 2015; 40: 106-114.
  • Bai M, Wang Y, Han R, et al. Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis. The Journal of Nutritional Biochemistry 2021;87: 1-9.
  • Mattson MP, Longo VD, Harvie M. Impact of İntermittent Fasting on Health and Disease Processes. Science Direct 2017;39: 46-58.
  • Most J, Tosti V, Redman LM, et al. Calorie Restriction in Humans: an Update. Ageing Research Reviews 2017; 39: 36-45.
  • Roman SN, Fitzgerald KC, Beier M, et al. Safety and feasibility of various fasting-mimicking diets among people with multiple sclerosis. Multiple Sclerosis and Related Disorders 2020; 42:1-7.
  • Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 2009; 50: 304-317.
  • Pinto A, Bonucci A, Maggi E, et al. Anti-Oxidant and Antiinflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Diseas. Antioxidants 2018; 7(5): 1-16.
  • Kim DY, Hao J, Liu R, et al. Inflammationmediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis. Plos One 2012; 7(5):1-8.
  • McDonald TJW, Cervenka MC. Ketogenic Diets for Adult Neurological Disorders. Neurotherapeutics 2018;15(4): 1018-1031.
  • Barañano KW, Hartman AL. The Ketogenic Diet: Uses in Epilepsy and Other Neurologic Illnesses. Current Treatment Options in Neurology 2008, 10: 410– 419.
  • Mowry EM, Azevedo CJ, McCulloch CE, et al. Body Mass İndex, but not Vitamin D Status, is Associated With Brain Volume Change in MS. Neurology 2018; 91(24): 2256-2264.
  • Schüpbach R, Wegmüller R, Berguerand C, et al. Micronutrient Status and İntake in Omnivores, Vegetarians and Vegans in Switzerland. Eur. J. Nutr 2017; 56(1): 283–293.
  • McDougall, J, Thomas LE, McDougall C, et al. Effects of 7 Days on an ad Libitum Low-fat Vegan Diet: the McDougall Program cohort. Nutr J 2014;13(99): 1-7.
  • Mente A, Koning L, Shannon H. A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease. Arch Intern Med 2009; 169(7): 659-669.
  • Milijkoviç D, Dekanski D, Milijkoviç M., et al. Dry Olive Leaf Extract Ameliorates Experimental Autoimmune Encephalomyelitis. Clinical Nutrition 2009; 28(3): 346-350.
  • Sedaghat F, Jessri M, Behrooz M, et al. Mediterranean Diet Adherence and Risk of Multiple Sclerosis: a Case-control Study. Asia Pacific Journal of Clinical Nutrition, 2016; 25(2): 377-384.
  • Esposito S, Sparaco M, et al. Lifestyle and Mediterranean diet adherence in a cohort of Southern Italian patients with Multiple Sclerosis. Multiple Sclerosis and Related Disorders 2021; 47: 1-8.
  • Thomsen HL, Jessen EB, Passali M, et al. The role of Gluten in Multiple Sclerosis: A Systematic Review. Multiple Sklerosis and Related Disorders 2019; 27: 156-163.
  • Passali M, Josefsen K, Frederiksen JL, et al. Current Evidence on the Efficacy of Gluten-Free Diets in Multiple Sclerosis, Psoriasis, Type 1 Diabetes and Autoimmune Thyroid Diseases. Nutrients 2020;12(8):1-26.
  • Ben-Ami Shor D, Barzilai O, Ram M, et al. Gluten sensitivity in multiple sclerosis: experimental myth or clinical truth?. Ann N Y Acad Sci 2009 ;1173:343-349.
  • Raehsler SL, Choung RS, Marietta EV, et al. Accumulation of Heavy Metals in People on a Gluten-Free Diet. Clinical Gastroenterology and Hepatology 2018;1: 244–251.
  • Özkarabulut A, Onur H, Yaşar İ. Multiple Skleroz (MS) Hastalığı Öncesi ve Sonrası Beslenme Alışkanlıklarının Karşılaştırılması, Yeterli ve Dengeli Beslenmenin MS Ataklarına Olan Etkisinin İrdelenmesi. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi 2018; 6:535-550.
  • Fitzgerald KC, Munger KL, Kochert K, et al. Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b. JAMA Neurolgy 2015; 72(12): 1458-1465.
  • Harbige LS, Sharief MK. Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. British Journal of Nutrition 2007; 98(1):46–53.
  • Wilck N, Matus MG, Kearney SM, et al. Salt-Responsive Gut Commensal Modulates TH17 Axis and Disease. Nature 2017; 551: 585-589.
  • Kleinewietfeld M, Manzel A, Titze J, et al. Sodium Chloride Drives Autoimmune Disease by the İnduction of Pathogenic TH17 cells. Nature 2013; 496: 518-522.
There are 63 citations in total.

Details

Primary Language Turkish
Subjects Traditional, Complementary and Integrative Medicine, Primary Health Care
Journal Section Derleme Bölümü
Authors

Tülin Karaağaç This is me 0000-0002-0336-1771

Ezgi Eriman This is me 0000-0002-1878-7919

Hülya Doğan This is me 0000-0002-4209-7539

Ayşegül Bayramoğlu 0000-0001-8567-807X

Publication Date December 30, 2021
Submission Date April 21, 2021
Published in Issue Year 2021 Volume: 8 Issue: 2

Cite

APA Karaağaç, T., Eriman, E., Doğan, H., Bayramoğlu, A. (2021). MULTİPLE SKLEROZ BESLENME TEDAVİSİNDE GÜNCEL YAKLAŞIMLAR. ERÜ Sağlık Bilimleri Fakültesi Dergisi, 8(2), 48-58.