Biosynthesis of Naringenin@Cu (II), Zn (II) Hybrid Nanoflower: Anticancer Activity Assay process

Year 2024, , 385 - 399, 31.08.2024

Burcu Somtürk Yılmaz

https://doi.org/10.18185/erzifbed.1434398

Abstract

In the study, the synthesis of organic-inorganic hybrid nanoflowers, which have a flower-like structure and are called nanoflowers, was carried out. For this purpose, hybrid nanoflower synthesis was carried out using naringenin as the organic part and different metal ions (Cu and Zn) as the inorganic part. Various analyzes were carried out to characterize the synthesized nanoflowers (such as SEM, EDX, FTIR, XRD). In addition, the anticancer activities of hybrid nanoflowers were tested on the MCF7 (breast cancer) cell line. It was concluded that there was a good increase in anticancer activity when naringenin was converted into hybrid nanoflower form. In particular, the anticancer activity of hybrid nanoflowers synthesized with Zn metal ion was quite excellent. This means that Zn hybrid nanoflowers may be a safer therapeutic alternative than others.

Keywords

nanoflower, anticancer, antimicrobial, naringenin

Supporting Institution

Erciyes Üniversitesi

Thanks

The author would like to thank Erciyes University, Drug Application and Research Center (ERFARMA) for laboratory and device support.

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