Evaluation of Pro-Drug Properties in a Novel Schiff Base-Incorporated Pt(II) Complex

Year 2024, , 410 - 425, 31.08.2024

Salih Günnaz , Khan Mohammad Rahmat , Sevil İrişli

https://doi.org/10.18185/erzifbed.1451093

Abstract

The present investigation involved the synthesis of a new Schiff base and its platinum complex. The chemical structures of both the ligand and the complex were determined through the utilization of various analytical techniques, including 1H-NMR, 13C-NMR, FT-IR, and elemental analysis. Moreover, the interaction between the synthesized complex and Amyloid-Beta, a crucial factor in the pathogenesis of Alzheimer's disease, was explored. This interaction was assessed by means of fluorescence spectrophotometry. Additionally, the influence of the histidine amino acid, which has been reported in the literature to play a significant role in the interaction between Amyloid-Beta and coordination compounds, was monitored using 1H-NMR. These investigations have the potential to enhance our comprehension of the chemical structure and biological effects of ligands and complexes. Furthermore, they may contribute to the advancement of knowledge regarding important neurodegenerative disorders such as Alzheimer's disease, as well as the development of potential therapeutic strategies.

Keywords

Alzheimer, Amyloid Beta, Platinum Complexes, Schiff Bases

Ethical Statement

There are no ethical issues regarding the publication of this study

Supporting Institution

Ege University

Project Number

FYL-2019-20437

Thanks

Financial support from Ege University (Project FYL-2019-20437) is gratefully acknowledged.

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