Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini

Güzide Pekcan Ertokuş; Tahir Özer

doi:10.18185/erzifbed.690778

Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini

Abstract

Bu çalışmada, Parkinson hastalığının tedavisinde kullanılan ilaç numunesindeki levodopa ve benserazid maddelerinin spektrofotometrik olarak kemometrik metotlarla tayini gerçekleştirilmiştir. Deneysel çalışmada maddelerin spektrofotometrik özellikleri belirlendikten sonra her bir maddenin uygun oranlarıyla karıştırılmasıyla yapay karışımların spektrum verileri incelenmiştir. En son aşamada tablet numunesi analizi yapılmıştır. Kemometrik yöntemlerden, temel bileşen regresyonu yöntemi (PCR) ve kısmi en küçük kareler yöntemi (PLS), sentetik karışım ve tablet numunesindeki miktar tayininde başarı ile uygulanmıştır. Hesaplanan veriler, istatistik olarak incelendiklerinde hem hesaplanan geri kazanım değerleri yüksek hem de standart sapmalar yeterince küçüktür. Uygulanan kemometrik yöntemler yardımıyla elde edilen sonuçlar son derece hızlı, basit ve güvenilir sonuçlardır.

Keywords

Supporting Institution

SÜLEYMAN DEMİREL ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ

Project Number

FYL-2018-6859

Thanks

Bu çalışma, Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından “FYL-2018-6859” kodlu proje ile desteklenmiştir.

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Details

Primary Language

Turkish

Subjects

Engineering

Journal Section

Research Article

Authors

Güzide Pekcan Ertokuş ^*
0000-0001-9230-5634
Türkiye

Tahir Özer
0000-0001-8405-1929
Türkiye

Publication Date

August 31, 2020

Submission Date

February 18, 2020

Acceptance Date

August 30, 2020

Published in Issue

Year 2020 Volume: 13 Number: 2

DOI

https://doi.org/10.18185/erzifbed.690778

IZ

https://izlik.org/JA96ZG65MG

Cite

RIS / Bibtex

APA

Pekcan Ertokuş, G., & Özer, T. (2020). Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini. Erzincan University Journal of Science and Technology, 13(2), 669-676. https://doi.org/10.18185/erzifbed.690778

AMA

1.Pekcan Ertokuş G, Özer T. Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini. Erzincan University Journal of Science and Technology. 2020;13(2):669-676. doi:10.18185/erzifbed.690778

Chicago

Pekcan Ertokuş, Güzide, and Tahir Özer. 2020. “Parkinson Hastalığının Tedavisinde Kullanılan Levodopa Ve Benserazid Etken Maddelerinin Kemometrik Tayini”. Erzincan University Journal of Science and Technology 13 (2): 669-76. https://doi.org/10.18185/erzifbed.690778.

EndNote

Pekcan Ertokuş G, Özer T (August 1, 2020) Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini. Erzincan University Journal of Science and Technology 13 2 669–676.

IEEE

[1]G. Pekcan Ertokuş and T. Özer, “Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini”, Erzincan University Journal of Science and Technology, vol. 13, no. 2, pp. 669–676, Aug. 2020, doi: 10.18185/erzifbed.690778.

ISNAD

Pekcan Ertokuş, Güzide - Özer, Tahir. “Parkinson Hastalığının Tedavisinde Kullanılan Levodopa Ve Benserazid Etken Maddelerinin Kemometrik Tayini”. Erzincan University Journal of Science and Technology 13/2 (August 1, 2020): 669-676. https://doi.org/10.18185/erzifbed.690778.

JAMA

1.Pekcan Ertokuş G, Özer T. Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini. Erzincan University Journal of Science and Technology. 2020;13:669–676.

MLA

Pekcan Ertokuş, Güzide, and Tahir Özer. “Parkinson Hastalığının Tedavisinde Kullanılan Levodopa Ve Benserazid Etken Maddelerinin Kemometrik Tayini”. Erzincan University Journal of Science and Technology, vol. 13, no. 2, Aug. 2020, pp. 669-76, doi:10.18185/erzifbed.690778.

Vancouver

1.Güzide Pekcan Ertokuş, Tahir Özer. Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini. Erzincan University Journal of Science and Technology. 2020 Aug. 1;13(2):669-76. doi:10.18185/erzifbed.690778

Cited By

Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances

Cumhuriyet Science Journal

https://doi.org/10.17776/csj.1351879