Mikrodamarların Sertliğinin Hemodinamik Üzerine Etkisi, bir FSI Analizi

Abstract

Kardiyovasküler hastalıkların araştırmasında bilgisayarla modelleme son zamanlarda önemli ilerleme kaydetmiştir. Bu çalışmada; mikrodamar sertliğinin kan basıncı ve kan akışından kaynaklanan çeper kayma gerilmesi (WSS) üzerindeki etkisi, sayısal yöntemle analiz edilmiştir. Çalışmada üç mikrodamar tasarlanmıştır. Tasarlanan bu üç mikrodamar 100, 200 ve 300 mikron çaplarında ve sırasıyla 10, 20 ve 30 mikron kalınlıkta tasarlanmıştır. Daha sonra her mikrodamar için malzeme özelliği olarak 0.4, 0.6 ve 0.8 MPa’lık üç farklı elastisite modülü uygulanmıştır. Mikrodamarlarda ki kan akışı, CFD yöntemi ile analiz edilmiştir. Damar sertliğindeki değişimin kanın uyguladığı basınç üzerindeki etkisini ve ayrıca kan akışının damarın deformasyonu üzerindeki etkisini incelemek için bir sıvı-yapı etkileşimli (FSI) analizi gerçekleştirilmiştir. Analizler sonucunda: Damar sertliğinin artmasının kan basıncını ve WSS'i artırdığını ayrıca mikrodamarın deformasyon kabiliyetini düşürdüğünü göstermiştir. Bu çalışmanın sonuçları, kardiyovasküler hastalıkların özellikle mikron boyutlu damarlarda incelenmelerine ışık tutmuştur.

Keywords

• Hipertansiyon
• Çeper kayma gerilmesi
• Damar sertliği
• FSI analizi
• CFD analizi

Effect Of Microvessels Stiffness on Hemodynamic; an FSI Analysis

Abstract

The exploits of computer modelling in the study of cardiovascular disease have recently gained significant progress. In this study, the effect of microvessels stiffness on blood pressure and blood flow-induced wall shear stress (WSS) was analysed numerically. Three microvessels in diameters of 100, 200 and 300 microns with respectively media thicknesses of 10, 20 and 30 microns, were designed. Then for each model as material properties, the elastic modulus of 0.4, 0.6 and 0.8 MPa was applied. The blood flow within the microvessels was investigated using CFD analysis. A fluid-structure interaction (FSI) multiphysics analysis was performed to observe the effect of vascular stiffness on blood pressure and vice versa the effect of blood flow on the microvessel deformation. The result of the analysis showed that increasing the stiffness of the vessel increases blood pressure and WSS, and as well as causes a decline in its deformation capability. The outcome of this theoretical study shed more light on understanding cardiovascular diseases roots and origin, especially in micron-sized vessels.

Keywords

• Hypertension
• Wall shear stress
• Vessel stiffness
• FSI analysis
• CFD analysis

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