CHOLINERGIC EFFECTS OF SAGE (SALVIA OFFICINALIS L.) LEAVES
Abstract
The cholinergic basal forebrain (CBF) has been implicated in cognitive functions including learning, memory, and attention. The role of the basal forebrain cholinergic system in learning has been widely debated. Early studies are supported a role for the basal forebrain cholinergic system in general learning and memory mechanisms. The leaves of Salvia officinalis L. (sage) are well known for their antioxidative properties. There is increasing evidence to suggest that many degenerative diseases, such as brain dysfunction, cancer, heart diseases, and weakened immune system, could be the result of cellular damage caused by free radicals, and antioxidants present in human diet may play an important role in disease prevention.
Keywords
References
- Almkvist, O., Jelic, V., Amberla, K., Hellstrom-Lindahl, E., Meurling, L., Nordberg, A. 2001. Responder characteristics to a single oral dose of cholinesteraseinhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord. 12: 22 –32.
- Bartus, R.T., Dean, R.L., Beer, B. and Lippa, A.S. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217: 408 -414.
- Bigl, V., Woolf, N.J. and Butcher, L.L. 1982. Cholinergic projection from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis. Brain Res. Bull. 8: 727-749.
- Bouaziz, M., Yangui, T., Sayadi, S., et al. 2009. Disinfectant properties of essential oils from Salvia officinalis L. cultivated inTunisia. Food and Chemical Toxicology. 47 (11): 2755–2760.
- Cho, H.M., Song, D.K., Suh, H.W., KimY.H. 1994. Serotonin uptake blocking activity from herb medicines. Neuropsychopharmacology. 10: 137.
- Chung, I.W., Chen, G., Manji, H., Kim, Y.S., Ahn, J.S., Potter, W.Z., et al. 1994. Binding of natural medicinal products to alpha 2 adrenergic receptors. Neuropsychopharmacology. 10: 137.
- Conner, J.M., Kulczycki, M. and Tuszynski, M.H. 2010. Unique Contributions of Distinct Cholinergic Projections to Motor Cortical Plasticity and Learning. Oxford Journals. Volume 20, Issue 11: pp. 2739-2748.
- Davies, P. and Maloney, A.J. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 2: 1403.
Details
Primary Language
English
Subjects
Engineering
Journal Section
Research Article
Authors
Publication Date
January 11, 2015
Submission Date
April 1, 2014
Acceptance Date
-
Published in Issue
Year 2014 Volume: 7 Number: 2