Abstract
Nazal yolla ilaç uygulamanın, parenteral ve oral uygulamaya nazaran birçok avantajı vardır. Bazı ilaçlar emilim ve ilk geçiş metabolizması nedeniyle ağızdan uygulandığında etkisizdir. Bu nedenle, sulu çözünürlük probleminin üstesinden gelinebilirse, burun içi yol uygulama için alternatif bir yöntem olacaktır. Bu çalışmada, indometazin-ksilometazolin hidroklorür kombinasyonunun burunda kalma süresinin uzatmak amacıyla emülsiyon formülasyonu yeni bir yaklaşım olarak önerilmiştir. F1 ve F2 emülsiyonlarının pH değeri sırasıyla 9,4 ve 5,6 olarak belirlenmiştir. F1 ve F2 formülasyonlarının partikül boyutunun sırasıyla 136.8 ± 24 nm ve 269.5 ± 66 nm olduğu bulunmuştur.
İndometazin-ksilometazolin içeren y/s emülsiyon formülasyonu, iv ve po uygulamasına bir alternatif olarak düşünülebilir. Bu ilaç uygulaması, farmakolojik etkisinin hızlı başlangıcını sağlamak için verilebilir
Supporting Institution
Proje herhangibir Kurum tarafından desteklenmemiştir.
References
- 6. Applications of New Validated RP-HPLC Method for Determination of Indomethacin and its Hydrolytic Degradants using Sodium Acetate Buffer Drug. Indian Journal of Pharmaceutical Education and Research, Vol: 51, Issue:3, 2017.
- 7. G. S. Tirucherai, I. Pezron, and A. K. Mitra. Novel approaches to nasal delivery of peptides and proteins. STP Pharma Sci 12:3– 12 (2002).
- 8. P. Kan, Z. B. Chen, R. Y. Kung, C. J. Lee, and I. M. Chu. Study on the formulation of o/w emulsion as carriers for lipophilic drugs. Colloids Surf B: Biointerfaces 15:117–125 (1999).
- 9. Jean-Louis Salager Emulsion Properties and Related Know-how to Attain Them Pharmaceutical Emulsions and Suspensions 74-122 MARCEL DEKKER, INC. 2000 NEW YORK – BASEL
- 10. M. Danaei, M. Dehghankhold, S. Ataei, F. Hasanzadeh Davarani, R. Javanmard, A. Dokhani, S. Khorasani and M. R. Mozafari Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems Pharmaceutics (2018) 2-17
Abstract
Nasal administration has many advantages over nasal, parenteral or oral administration. Some drugs are ineffective when administered orally due to absorption and first pass metabolism. Therefore, if the aqueous solubility problem can be overcome, the intranasal route will be an alternative method for administration. In this study, emulsion formulation was proposed as a new approach in order to increase the duration of the indomethacin-xylometazoline hydrochloride combination in the nose. The pH value of F1 and F2 emulsions were determined 9.4 and as 5.6 respectively. The particle size of F1 and F2 formulations were found to be 136.8±24 nm and 269.5±66 nm respectively.
Formulation of o/w emulsion IND and XYL may be considered as an alternative to iv and po administration. This administration of drugs may be delivery to achieve rapid onset of its pharmacological effect.
References
- 6. Applications of New Validated RP-HPLC Method for Determination of Indomethacin and its Hydrolytic Degradants using Sodium Acetate Buffer Drug. Indian Journal of Pharmaceutical Education and Research, Vol: 51, Issue:3, 2017.
- 7. G. S. Tirucherai, I. Pezron, and A. K. Mitra. Novel approaches to nasal delivery of peptides and proteins. STP Pharma Sci 12:3– 12 (2002).
- 8. P. Kan, Z. B. Chen, R. Y. Kung, C. J. Lee, and I. M. Chu. Study on the formulation of o/w emulsion as carriers for lipophilic drugs. Colloids Surf B: Biointerfaces 15:117–125 (1999).
- 9. Jean-Louis Salager Emulsion Properties and Related Know-how to Attain Them Pharmaceutical Emulsions and Suspensions 74-122 MARCEL DEKKER, INC. 2000 NEW YORK – BASEL
- 10. M. Danaei, M. Dehghankhold, S. Ataei, F. Hasanzadeh Davarani, R. Javanmard, A. Dokhani, S. Khorasani and M. R. Mozafari Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems Pharmaceutics (2018) 2-17
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Makaleler |
| Authors | |
| Publication Date | December 31, 2020 |
| Published in Issue | Year 2020 |