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KOAH Hastalarında Demodex (Acari: Demodicidae) Enfestasyonu ve İmmunosüpresyon ile Arasındaki İlişki

Year 2017, Volume: 10 Issue: 2, 220 - 231, 22.12.2017

Abstract

Bu çalışma KOAH hastalarında Demodex enfestasyonunun belirlenmesi ve
immünosüpresyon ile arasındaki ilişkinin ortaya konulması amacıyla yapıldı. Çalışmaya
Erzincan Üniversitesi Mengücek Gazi Eğitim ve Araştırma Hastanesi Göğüs
Hastalıkları Polikliniğine başvuran ve KOAH (Kronik Obstrüktif Akciğer
Hastalığı) tanısı konulan 101 hasta ve herhangi bir kronik veya dermatolojik
hastalığı olmayan 80 kontrol dahil edildi. Erzincan Üniversitesi Klinik
Araştırmalar Etik Kurulu’ndan onay (Karar no:
2016-08/07) alındıktan sonra tüm katılımcılara bilgilendirilmiş
onam formu okunarak imzalatıldı.
Katılımcıların sağ ve
sol yanağından Standart Yüzeyel Deri Biyopsi (SYDB) yöntemi ile örnekler
alınarak ışık mikroskobunda incelendi. Çalışmada hastaların %82,2’sinde Demodex folliculorum (ortalama 21,78/cm2),
%40,6’sında D. brevis (ortalama 4.70/cm2) olmak üzere %87,1’inde Demodex spp. (ortalama 22,74/cm2);
kontrollerin ise %25’inde D. folliculorum
(ortalama 5,05/cm2), %12,5’inde D.
brevis (ortalama 1,5/cm2)
olmak üzere %27,5’inde Demodex spp.
(ortalama 5,27/cm2) saptandı. Ayrıca Demodex yoğunluğunun immünosüpresif tedavi alan KOAH hastalarında almayanlara
göre yaklaşık 3,5 kat daha fazla olduğu ve aradaki farkların istatistiki
bakımdan anlamlı olduğu tespit edildi. Sonuç olarak çalışmamızda KOAH
hastalarının kontrollerden daha fazla Demodex
ile enfeste olduğu ve immünosüpresyonun Demodex
yoğunluğunu önemli derecede arttırdığı belirlendi. Dolayısı ile immünosüpresif
tedavi alan hastalarda demodikozise bağlı cilt lezyonlarının gelişebileceği ve
bunun klinikte göz önünde bulundurulmasının faydalı olacağı düşünüldü.

References

  • Akdeniz, S., Bahçeci, M., Tuzcu, A.K., Harman, M., Alp, S. ve Bahçeci, S. 2002. Is Demodex folliculorum larger in diabetic patients? Journal of European Academy of Dermatology and Venereology, 16, 532-548.
  • Akilov, O.E. and Mumcuoğlu, K.Y. 2003. Association between human demodicosis and HLA class-I. Clinical and Experımental Dermatology, 28: 70-73.
  • Akilov, O.E. and Mumcuoğlu, K.Y. 2004. Immune Response in demodicosis. Journal of European Academy of Dermatology and Venereology, 18, 440-444.
  • Aycan, Ö.M., Otlu, G.H., Karaman, Ü., Daldal, N. ve Atambay, M. 2007. Çeşitli hasta ve yaş gruplarında Demodex spp. görülme sıklığı. Türkiye Parazitoloji Dergisi, 31(2): 115-118.
  • Aytekin, S. ve Göktay, F. 2015. Demodikozis. Türkiye Klinikleri Journal of Dermatology Special Topics, 8(3), 35-41.
  • Aytekin, S. Yaşar, Ş. ve Göktay, F. 2017. Demodex infestasyonları. Türkiye Klinikleri Journal of Dermatology Special Topics, 10(2), 169-174.
  • Benk Silfeler, D., Keskin Kurt, R., Aycan Kaya, Ö., Yengil, E., Hamamcı, B., Okyay, A.G. ve Beyazıt, A. 2015. Demodex folliculorum in polycystic ovary syndrome patients. European Review for Medical and Pharmacological Sciences, 19, 1141-1145.
  • Bochkov A. 3/7/2005. Synopsis of the described Arachnida of the world. 22/07/2017 tarihinde http://bug.tamu.edu/research/collection/hallan/Acari/0ReportHi.htm adresinden alınmıştır.
  • Casas, C., Paul, C., Lahfa, M., Livideanu, B., Lejeune, O., Alvarez-Georges, S., Saint-Martory, C., Deoguy, A., Mengeaud, V., Ginisty, H., Durbise, E., Schmitt, A.M. and Redoules, D. 2013. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Experimental Dermatology, 21, 906-910.
  • Çiftci, İ.H., Dündar, U., Cetinkaya, Z., Kulaş, M., Kıyıldı, N., Türel, A., Evcik, D. ve Kavuncu, V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52(1), 70-73.
  • Desch, C. and Nutting, W.B. 1972. Demodex folliculorum (Simon) and D. brevis Akbulatova of man: redescription and reevaluation. The Journal of Parasitology, 58(1), 169-177.
  • Desch, C. and Nutting, W.B. 1977. Morphology and functional anatomy of Demodex folliculorum (Simon) of man. Acarologia, 519(3), 422-462.
  • Dolenc-Voljc, M., Pohar, M. and Lunder, T. 2005. Density of Demodex folliculorum in perioral dermatitis. Acta Dermato Venereologica, 85, 211-215.
  • Durmaz, S., Yula, E., Aycan Kaya, Ö., Aksoy Gökmen, A., Kılınç, C., Atambay, M., Ekiz, O., Gözükara Bağ, H. ve Pektaş, B. 2015. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behçet’s disease. Biomedical Research, 26(3), 549-555.
  • El-Bassiouni S.O., Ahmed, J.A., Younis, A.I., Ismail, M.A., Saadawi, A.N. and Bassiouni, S.O. 2005. A study on Demodex folliculorum mite density and immune response in patients with facial dermatoses. Journal of Egyptian Society of Parasitology, 35, 899-910.
  • Erbağcı, Z. ve Özgöztaşı, O. 1998. The significance of Demodex folliculorum density in rosacea. International Journal of Dermatology, 37(6), 421-425.
  • Forton F.M.N. 2012. Papulopustular rosecea, skin immunity and Demodex: pityriasis folliculorum as a missing link. Journal of European Academy of Dermatology and Venereology, 26,19-28.
  • Forton, F.M., Germaux, M.A., Thibaut, S.C., Stene, J.J., Brasseur, T.V., Mathys, C.L., Tytgat, M.D and Laporte, M.F. 2015. Demodicosis: descriptive classification and status of rosacea, in response to prior classification proposed. Journal of the European Academy of Dermatology and Venereology, 29(4), 829-832.
  • Georgala, S., Katoulis, A.C., Kylafis, G.D., Koumantaki‐Mathioudaki, E., Georgala, C. and Aroni, K. 2001. Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. Journal of the European Academy of Dermatology and Venereology, 15(5), 441-444.
  • Izdebska, J.N., Rolbiecki, L. 2016. A new genus and species of demodecid mites from the tongue of a house mouse Mus musculus: description of adult and immature stages with data on parasitism. Medical and Veterinary Entomology, 30(2), 135-143.
  • Jansen, T., Kastner, U., Kreuter, A. and Altmeyer, P. 2001. Rosacea-like domodicidosis associated with acquired immunodeficiency syndrome. British Journal of Dermatology, 144, 139-142.
  • Karıncaoğlu, Y., Eşrefoğlu Seyhan, M., Bayram, N., Aycan, Ö. ve Taşkapan, H. 2005. Incidence of Demodex folliculorum in patients with end stage chronic renal failure. Renal failure, 27(5), 495-499.
  • Kokaçya, M.H., Hamamcı, B., Çöpoğlu, Ü. S. ve Aycan Kaya, Ö. 2015. Demodex parazytes in schizophrenia. Journal of Clinical and Analytical Medicine, 1, 6-9.
  • Kulaç, M., Çiftçi, İ.H., Karaca, S. ve Çetinkaya, Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal of Dermatology, 47, 72-77.
  • Lawrence, H. 1916. On a skin eruption associated with the presence of great numbers of Demodex folliculorum. Medical Journal of Australia, 2, 555.
  • Mumcuoğlu, K.Y. and Akilov O.E. 2005. The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis. Dermatology, 210, 109-114.
  • Okyay P., Ertabaklar, H., Savk, E. ve Ertuğ, S. 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. Journal of European Academy of Dermatology and Venereology, 20, 474-476.
  • Özçelik, S., Sümer, Z., Değerli, S., Özyazıcı, G., Berksoy Hayta, S., Akyol, M. ve Candan, F. 2007. Kronik böbrek yetmezliği olan hastalarda Demodex folliculorum görülme sıklığı. Türkiye Parazitoloji Dergisi, 31(1), 66-68.
  • Rios-Yuil, J.M. and Mercadillo-Perez, P. 2013. Evaluation of Demodex folliculorum as a risk factor for the diagnosis of rosacea in skin biopsies. Mexico's General Hospital (1975-2010). Indian Journal of Dermatology, 58(2), 157.
  • Rufli, T. and Mumcuoğlu, K.Y. 1981. The hair follicle mites D. folliculorum and D.brevis: biology and medical importance, Dermatology, 162, 1-11.
  • Saygı, G., Marufi, M., Koyluoğlu, Z. 1984. Three Demodex folliculorum phenomena, one detected with cellophone band. Türkiye Parazitoloji Dergisi, 7, 137-144.
  • Taş Cengiz, Z., Yılmaz H., Akdeniz, N., Çiçek, M., Özkol, H ve Çalka, Ö. 2010. Associated of demodicosis with acne rosacea. Pakistan Journal of Medical Science, 26(3), 640-643.
  • Tilki, E., Zeytun, E. ve Doğan, S. ‘‘Demodicidae familyasının (Acari) tür listesi’’. III. International Congress on Zoology and Technology, s. 81, 2017a, Afyonkarahisar, Türkiye.
  • Tilki, E., Zeytun, E. ve Doğan, S. 2017b. Erzincan ilinde Demodex folliculorum ve Demodex brevis (Acari: Demodicidae) yaygınlığı ve yoğunluğu. Türkiye Parazitoloji Dergisi, 41(2), 80-86.
  • Vestbo, J., Hurd, S.S., Agusti, A.G., Jones, P.W., Vogelmeier, C., Anzueto, A., Barnes, P.J., Fabbri, M.L., Martinez, F.J., Nishimura, M., Stockley, R.A., Sin, D.D. and Roisin, R.R. 2013. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American Journal of Rrespiratory and Critical Care Medicine, 187(4), 347-365.
  • Yağdıran Düzgün, Ö. ve Aytekin, S. 2007. Comparison of Demodex folliculorum density in haemodialysis patients with a control group. Journal of the European Academy of Dermatology and Venereology, 21: 480-483.
  • Yengil, E., Çevik, C., Aycan Kaya, Ö., Taner, M., Akkoca, A.N. ve Özer, C. 2014. Relationship between Demodex folliculorum and allergic rhinitis in adults. Acta Medica Mediterranea, 30, 27-31.
  • Zeytun, E., Tilki, E., Doğan, S. ve Mumcuoğlu, K.Y. 2017. The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. International Journal of Dermatology, 56(7), 762-766.
  • Zeytun, E. 2017. Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: a cross-sectional study. Turkish Journal of Geriatrics, 20(2), 142-150.
  • Zhao, Y.E., Peng, Y., Wang, X.L., Wu, L.P., Wang, M., Yan, H.L. and Xiao, S.X. 2011. Facial dermatosis associated with Demodex: a case-control study. Journal of Zhejiang University-Science B, 12(12), 1008-1015.
Year 2017, Volume: 10 Issue: 2, 220 - 231, 22.12.2017

Abstract

References

  • Akdeniz, S., Bahçeci, M., Tuzcu, A.K., Harman, M., Alp, S. ve Bahçeci, S. 2002. Is Demodex folliculorum larger in diabetic patients? Journal of European Academy of Dermatology and Venereology, 16, 532-548.
  • Akilov, O.E. and Mumcuoğlu, K.Y. 2003. Association between human demodicosis and HLA class-I. Clinical and Experımental Dermatology, 28: 70-73.
  • Akilov, O.E. and Mumcuoğlu, K.Y. 2004. Immune Response in demodicosis. Journal of European Academy of Dermatology and Venereology, 18, 440-444.
  • Aycan, Ö.M., Otlu, G.H., Karaman, Ü., Daldal, N. ve Atambay, M. 2007. Çeşitli hasta ve yaş gruplarında Demodex spp. görülme sıklığı. Türkiye Parazitoloji Dergisi, 31(2): 115-118.
  • Aytekin, S. ve Göktay, F. 2015. Demodikozis. Türkiye Klinikleri Journal of Dermatology Special Topics, 8(3), 35-41.
  • Aytekin, S. Yaşar, Ş. ve Göktay, F. 2017. Demodex infestasyonları. Türkiye Klinikleri Journal of Dermatology Special Topics, 10(2), 169-174.
  • Benk Silfeler, D., Keskin Kurt, R., Aycan Kaya, Ö., Yengil, E., Hamamcı, B., Okyay, A.G. ve Beyazıt, A. 2015. Demodex folliculorum in polycystic ovary syndrome patients. European Review for Medical and Pharmacological Sciences, 19, 1141-1145.
  • Bochkov A. 3/7/2005. Synopsis of the described Arachnida of the world. 22/07/2017 tarihinde http://bug.tamu.edu/research/collection/hallan/Acari/0ReportHi.htm adresinden alınmıştır.
  • Casas, C., Paul, C., Lahfa, M., Livideanu, B., Lejeune, O., Alvarez-Georges, S., Saint-Martory, C., Deoguy, A., Mengeaud, V., Ginisty, H., Durbise, E., Schmitt, A.M. and Redoules, D. 2013. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Experimental Dermatology, 21, 906-910.
  • Çiftci, İ.H., Dündar, U., Cetinkaya, Z., Kulaş, M., Kıyıldı, N., Türel, A., Evcik, D. ve Kavuncu, V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52(1), 70-73.
  • Desch, C. and Nutting, W.B. 1972. Demodex folliculorum (Simon) and D. brevis Akbulatova of man: redescription and reevaluation. The Journal of Parasitology, 58(1), 169-177.
  • Desch, C. and Nutting, W.B. 1977. Morphology and functional anatomy of Demodex folliculorum (Simon) of man. Acarologia, 519(3), 422-462.
  • Dolenc-Voljc, M., Pohar, M. and Lunder, T. 2005. Density of Demodex folliculorum in perioral dermatitis. Acta Dermato Venereologica, 85, 211-215.
  • Durmaz, S., Yula, E., Aycan Kaya, Ö., Aksoy Gökmen, A., Kılınç, C., Atambay, M., Ekiz, O., Gözükara Bağ, H. ve Pektaş, B. 2015. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behçet’s disease. Biomedical Research, 26(3), 549-555.
  • El-Bassiouni S.O., Ahmed, J.A., Younis, A.I., Ismail, M.A., Saadawi, A.N. and Bassiouni, S.O. 2005. A study on Demodex folliculorum mite density and immune response in patients with facial dermatoses. Journal of Egyptian Society of Parasitology, 35, 899-910.
  • Erbağcı, Z. ve Özgöztaşı, O. 1998. The significance of Demodex folliculorum density in rosacea. International Journal of Dermatology, 37(6), 421-425.
  • Forton F.M.N. 2012. Papulopustular rosecea, skin immunity and Demodex: pityriasis folliculorum as a missing link. Journal of European Academy of Dermatology and Venereology, 26,19-28.
  • Forton, F.M., Germaux, M.A., Thibaut, S.C., Stene, J.J., Brasseur, T.V., Mathys, C.L., Tytgat, M.D and Laporte, M.F. 2015. Demodicosis: descriptive classification and status of rosacea, in response to prior classification proposed. Journal of the European Academy of Dermatology and Venereology, 29(4), 829-832.
  • Georgala, S., Katoulis, A.C., Kylafis, G.D., Koumantaki‐Mathioudaki, E., Georgala, C. and Aroni, K. 2001. Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. Journal of the European Academy of Dermatology and Venereology, 15(5), 441-444.
  • Izdebska, J.N., Rolbiecki, L. 2016. A new genus and species of demodecid mites from the tongue of a house mouse Mus musculus: description of adult and immature stages with data on parasitism. Medical and Veterinary Entomology, 30(2), 135-143.
  • Jansen, T., Kastner, U., Kreuter, A. and Altmeyer, P. 2001. Rosacea-like domodicidosis associated with acquired immunodeficiency syndrome. British Journal of Dermatology, 144, 139-142.
  • Karıncaoğlu, Y., Eşrefoğlu Seyhan, M., Bayram, N., Aycan, Ö. ve Taşkapan, H. 2005. Incidence of Demodex folliculorum in patients with end stage chronic renal failure. Renal failure, 27(5), 495-499.
  • Kokaçya, M.H., Hamamcı, B., Çöpoğlu, Ü. S. ve Aycan Kaya, Ö. 2015. Demodex parazytes in schizophrenia. Journal of Clinical and Analytical Medicine, 1, 6-9.
  • Kulaç, M., Çiftçi, İ.H., Karaca, S. ve Çetinkaya, Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal of Dermatology, 47, 72-77.
  • Lawrence, H. 1916. On a skin eruption associated with the presence of great numbers of Demodex folliculorum. Medical Journal of Australia, 2, 555.
  • Mumcuoğlu, K.Y. and Akilov O.E. 2005. The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis. Dermatology, 210, 109-114.
  • Okyay P., Ertabaklar, H., Savk, E. ve Ertuğ, S. 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. Journal of European Academy of Dermatology and Venereology, 20, 474-476.
  • Özçelik, S., Sümer, Z., Değerli, S., Özyazıcı, G., Berksoy Hayta, S., Akyol, M. ve Candan, F. 2007. Kronik böbrek yetmezliği olan hastalarda Demodex folliculorum görülme sıklığı. Türkiye Parazitoloji Dergisi, 31(1), 66-68.
  • Rios-Yuil, J.M. and Mercadillo-Perez, P. 2013. Evaluation of Demodex folliculorum as a risk factor for the diagnosis of rosacea in skin biopsies. Mexico's General Hospital (1975-2010). Indian Journal of Dermatology, 58(2), 157.
  • Rufli, T. and Mumcuoğlu, K.Y. 1981. The hair follicle mites D. folliculorum and D.brevis: biology and medical importance, Dermatology, 162, 1-11.
  • Saygı, G., Marufi, M., Koyluoğlu, Z. 1984. Three Demodex folliculorum phenomena, one detected with cellophone band. Türkiye Parazitoloji Dergisi, 7, 137-144.
  • Taş Cengiz, Z., Yılmaz H., Akdeniz, N., Çiçek, M., Özkol, H ve Çalka, Ö. 2010. Associated of demodicosis with acne rosacea. Pakistan Journal of Medical Science, 26(3), 640-643.
  • Tilki, E., Zeytun, E. ve Doğan, S. ‘‘Demodicidae familyasının (Acari) tür listesi’’. III. International Congress on Zoology and Technology, s. 81, 2017a, Afyonkarahisar, Türkiye.
  • Tilki, E., Zeytun, E. ve Doğan, S. 2017b. Erzincan ilinde Demodex folliculorum ve Demodex brevis (Acari: Demodicidae) yaygınlığı ve yoğunluğu. Türkiye Parazitoloji Dergisi, 41(2), 80-86.
  • Vestbo, J., Hurd, S.S., Agusti, A.G., Jones, P.W., Vogelmeier, C., Anzueto, A., Barnes, P.J., Fabbri, M.L., Martinez, F.J., Nishimura, M., Stockley, R.A., Sin, D.D. and Roisin, R.R. 2013. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American Journal of Rrespiratory and Critical Care Medicine, 187(4), 347-365.
  • Yağdıran Düzgün, Ö. ve Aytekin, S. 2007. Comparison of Demodex folliculorum density in haemodialysis patients with a control group. Journal of the European Academy of Dermatology and Venereology, 21: 480-483.
  • Yengil, E., Çevik, C., Aycan Kaya, Ö., Taner, M., Akkoca, A.N. ve Özer, C. 2014. Relationship between Demodex folliculorum and allergic rhinitis in adults. Acta Medica Mediterranea, 30, 27-31.
  • Zeytun, E., Tilki, E., Doğan, S. ve Mumcuoğlu, K.Y. 2017. The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. International Journal of Dermatology, 56(7), 762-766.
  • Zeytun, E. 2017. Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: a cross-sectional study. Turkish Journal of Geriatrics, 20(2), 142-150.
  • Zhao, Y.E., Peng, Y., Wang, X.L., Wu, L.P., Wang, M., Yan, H.L. and Xiao, S.X. 2011. Facial dermatosis associated with Demodex: a case-control study. Journal of Zhejiang University-Science B, 12(12), 1008-1015.
There are 40 citations in total.

Details

Subjects Engineering
Journal Section Makaleler
Authors

Erhan ZEYTUN 0000-0002-0138-9172

Hasan ÖLMEZ This is me

Publication Date December 22, 2017
Published in Issue Year 2017 Volume: 10 Issue: 2

Cite

APA ZEYTUN, E., & ÖLMEZ, H. (2017). KOAH Hastalarında Demodex (Acari: Demodicidae) Enfestasyonu ve İmmunosüpresyon ile Arasındaki İlişki. Erzincan University Journal of Science and Technology, 10(2), 220-231. https://doi.org/10.18185/erzifbed.335850