Poliprol-Karbon Nanotüp Modifiye Elektrotta Farmasötik Tabletlerde Metamizol Sodyumun Voltammetrik Tayini

Year 2019, Volume: 12 Issue: 1, 317 - 325, 24.03.2019

Volkan Özdokur , Çağrı Ceylan Koçak

https://doi.org/10.18185/erzifbed.460554

Cited By: 2

Abstract

Polipirol-karbon nanotüp
(PPy-CNT) kompozit elektrot, ultrasonikasyon ile eşleştirilmiş pulslu
polimerizasyon tekniği ile hazırlanmıştır. Bu teknik, hem ultrasonikasyon hem
de elektrokimyasal polimerizasyonun avantajlarına sahiptir. PPy-CNT kompoziti
pulslu depolama tekniği ile camımsı karbon elektrot (GCE) yüzeyine kolayca
modifiye edilmiş, ve metamizol yükseltgenmesine karşı camımsı karbon elektroda
göre katalitik aktivitesi yüksek bir yüzey elde edilmiştir. Hazırlanan elektrot
taramalı electron mikroskopu ile karakterize edilmiş ve pH:2 Britton-Robinson
tamponunda metamizol davranışı incelenmiştir. Diferansiyel pulse voltammetrisi
ile lineer aralık 5-500 mg L^-1 olarak saptanmış ve belirtme alt
sınırı1.6 mg L^-1 olarak hesaplanmıştır. Yapılan tüm çalışmalar
göstermiştir ki, PPY-CNT/GCE, metamizol tayini için yüksek duyarlılık,
seçimlilik ve kararlılığa sahiptir. PPy-CNT/GCE sensörü novalgine tablet
örneğine uygulanarak gerçek örnek analizi başarı ile gerçekleştirilmiştir. 

Keywords

PPy-CNT, Metamizol Sodyum, voltammetry

Voltammetric Determination of Metamizol Sodium in Pharmaceutical Tablets at Polypyrrole-Carbon Nanotube Modified Electrodes

Abstract

Poly pyrrole-carbon nanotube (PPy-CNT) composite electrodes were prepared with ultrasonication assisted
pulsed polymerization technique. This technique possesses both advantages of ultrasonication and
electrochemical polymerization. PPy-CNT composite was modified on the bare glassy carbon electrode (GCE)
surface easily with pulsed deposition technique that provide more catalytically active surface compared to the
bare GCE towards metamizol oxidation. Resulted electrode was characterized by scanning electron microscopy
and used for investigation of metamizaol in pH:2 Britton-Robinson buffer solution. In the differential pulse
voltammetric determination, the linear range was found as 5-500 mg L-1 with a detection limit of 1.6 mg L-1
.
The overall results showed that PPy-CNT electrode has an excellent sensitivity, selectivity and anti-fouling
properties for the voltammetric determination of metamizol. PPy-CNT/GCE sensor was applied succesfully to
the determination of metamizol in novalgine sample.

Keywords

PPy-CNT, Metamizol Sodium, Voltammetry, Pulsed Amperometric Deposition

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