In Vitro Cytotoxic Evaluation of a Silver(I) Complex Including Non-Steroidal Anti-Inflammatory Drug Niflumic Acid and 3-Picoline on Human-Derived Cancer Cell Lines

Year 2022, Volume: 15 Issue: 3, 736 - 748, 30.12.2022

Sema Çağlar , Ahmet Altay , Bülent Çağlar , Esma Kübra Kağan Yeniçeri , Betül Harurluoğlu

https://doi.org/10.18185/erzifbed.1130634

Abstract

Burada, steroidal olmayan anti-enflamatuar ilaç niflumik asit ve 3-pikolin içeren yeni bir gümüş(I) kompleksi sentezlendi ve FT-IR, 1H NMR, elemental ve termik analiz teknikleri ile karakterize edildi. Bu teknikler, sentezlenen kompleksin formülünün [Ag(nif)(3-pic)] olduğunu gösterdi. Kompleks, ligand (niflumik asit) ve gümüş iyonlarının tek başına sitotoksik yeteneği, insan meme adenokarsinomu (MDA-MB-453), akciğer adenokarsinomu (A-549), kolorektal adenokarsinom (HT-29) ve fare fibroblast hücre hatlarına (3T3-L1) karşı test edildi. XTT sonuçları, AgNO3 ve niflumik asidin tek başına kanser ve sağlıklı hücre hatları üzerinde orta düzeyde sitotoksisite sergilemesine rağmen, kompleksin kanser hücreleri üzerinde doza bağlı bir şekilde güçlü sitotoksik aktivite gösterdiğini gösterdi. Kompleksin en güçlü sitotoksisitesi ve en yüksek seçiciliği HT-29 hücrelerinde belirlendi. Bu bulgular, gelişmiş antikanser çalışmalarında yeni gümüş(I) kompleksinin değerlendirilmesi için temel çıktılar sağlar.

Keywords

Silver(I) complex, Niflumic acid, Cytotoxicity, Cell culture

Supporting Institution

Erzincan Binali Yıldırım University Scientific Research Projects Coordination Commission (EU-BAP)

Project Number

FBA-2020-683

Thanks

This work was financially supported by grants from Erzincan Binali Yıldırım University Scientific Research Projects Coordination Commission (EU-BAP) (Project No: FBA-2020-683).

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