Acil Serviste Akut Mekanik Bel Ağrılarında Ibuprofen 400 mg and 800 mg Intravenöz formlarının analjezik etkilerinin karşılaştırılması: Prospektif, Randomize Klinik ve Çift Kör Çalışma

Year 2024, Volume: 7 Issue: 2, 309 - 316, 05.07.2024

Safa Dönmez , Erdal Tekin , Ahmet Burak Erdem , Alp Şener , Miray Tümer Mehmet Yılmaz Nurullah İshak Işık , İbrahim Ozlu

https://doi.org/10.62425/esbder.1509208

Abstract

Amaç: Bu çalışmanın amacı, akut mekanik bel ağrısı için intravenöz (IV) ibuprofenin 400 mg ve 800 mg dozlarının analjezik etkinliğini karşılaştırmaktı.
Yöntemler: Orospektif, randomize, çift-kör kontrollü klinik bir çalışma tasarımı kullanıldı. Orta ila şiddetli akut bel ağrısı olan hastalar çalışmaya dahil edildi. Etik onay alındı ve hastalar yazılı onay verdiler. Çalışma etik kurallara ve İyi Klinik Uygulama prensiplerine uygun olarak yürütüldü.
Bulgular: 144 hastadan, demografik özellikler gruplar arasında benzerdi. 800 mg IV ibuprofen grubu, 400 mg grubuna göre üstün analjezik etkinlik gösterdi ve önemli bir yan etki rapor edilmedi.
Sonuç: Çalışma, akut mekanik bel ağrısı olan hastalarda 800 mg IV ibuprofen dozunun, 30. dakika hariç tüm zaman aralıklarında analjezi kontrolü sağlamada daha etkili olduğunu sonuçlandırdı.

Keywords

Akut bel ağrısı, ibuprofen, intravenöz, analjezik etkinlik

The Comparative Efficacy of Intravenous Ibuprofen 400 mg and 800 mg in Acute Mechanical Low Back Pain: A Prospective, Randomized, Double-Blind Clinical Study

Abstract

Objective: This study aimed to compare the analgesic efficacy of intravenous (IV) ibuprofen at doses of 400 mg and 800 mg for acute mechanical low back pain.
Methods: A Prospective, randomized, double-blind controlled clinical trial design was employed. Patients with moderate to severe acute low back pain were recruited from emergency departments. Ethical approval was obtained, and patients provided written consent. The study adhered to ethical guidelines and Good Clinical Practice principles.
Results: Of the 144 patients, demographic characteristics were similar between groups. The 800 mg IV ibuprofen group demonstrated superior analgesic efficacy compared to the 400 mg group, with no significant adverse effects reported.
Conclusion: The study concludes that the 800 mg IV dose of ibuprofen was more effective in providing analgesia control for patients with acute mechanical low back pain at all time intervals except for the 30th minute.

Keywords

Acute low back pain, ibuprofen, intravenous, analgesic efficacy

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