INVESTIGATION OF ROTAVIRUS AND ADENOVIRUS FREQUENCY IN PEDIATRIC PATIENTS WITH ACUTE GASTROENTERITIS

Abstract

This study aimed to determine the prevalence of rotavirus and adenovirus in children with viral gastroenteritis over a two-year period and to determine the distribution of these agents according to age, gender, season and year in a secondary state hospital in Mersin province.Stool samples of 1264 pediatric patients aged between one month and 18 years who were admitted to a secondary state hospital in Mersin province between January 1, 2022 and December 31, 2023 were retrospectively evaluated for rotavirus and adenovirus antigens. The rotavirus and adenovirus combo test kit (JusChek, Malaysia) was used that an immunochromatographic test designed for the qualitative detection of rotavirus and adenovirus antigens.Of 1264 patients, 167 (13.2%) were positive for rotavirus and 76 (6.0%) were positive for adenovirus. Of the positive cases, 156 (%12.3) were male and 87 (%6.9) were female and there was no significant difference between rotavirus and adenovirus positivity and gender. Both rotavirus and adenovirus antigen positivity were statistically significant in the 0-2 age and 0-5 age group compared to other age groups. When the distribution of rotavirus antigen positivity according to seasons was analyzed, a statistically significant difference was found in autumn and winter months, while no significant difference was found in the distribution of adenovirus antigen positivity according to seasons.Adenovirus and rotavirus should not be ignored in the etiology of gastroenteritis, especially in children. Therefore, rotavirus vaccination should be considered as an important prevention strategy to reduce the incidence of rotavirus-associated diarrhea, prevent hospitalizations, mortality and morbidity, and alleviate the economic burden of the disease.

Keywords

• Adenovirus
• gastroenteritis
• rotavirus.

AKUT GASTROENTERİTLİ ÇOCUK HASTALARDA ROTAVİRÜS VE ADENOVİRÜS SIKLIĞININ ARAŞTIRILMASI

Abstract

Bu çalışma, Mersin ilinde ikinci basamak bir devlet hastanesinde iki yıllık süre boyunca viral gastroenteritli çocuklarda rotavirüs ve adenovirüs prevalansını belirlemeyi ve bu etkenlerin yaş, cinsiyet, mevsim ve yıllara göre dağılımını tespit etmeyi amaçlamıştır. Mersin ilinde ikinci basamak bir devlet hastanesine1 Ocak 2022-31 Aralık 2023 tarihleri arasında başvuran, yaşları bir ay ile 18 yaş arasında değişen 1264 çocuk hastaya ait dışkı örnekleri rotavirüs ve adenovirüs antijenleri açısından retrospektif olarak değerlendirilmiştir. Rotavirüs ve adenovirüs antijenlerinin kalitatif tespiti için tasarlanmış immünokromatografik bir test olan rotavirüs ve adenovirüs kombo test kiti (JusChek, Malezya) kullanılmıştır. Toplam1264 hastanın 167 (%13.2)’sinde rotavirüs, 76 (%6.0)’sında adenovirüs pozitif bulunmuştur. Pozitif olguların 156 (%12.3)’sı erkek, 87(%6.9)’si kadın olup rotavirüs ve adenovirüs pozitifliği ile cinsiyet arasında anlamlı bir farklılığın olmadığı görülmüştür. Hem rotavirüs hem de adenovirüs antijen pozitifliği 0-2 yaş ve 0-5 yaş grubunda diğer yaş gruplarına göre daha yüksektir ve bu fark istatistiksel olarak anlamlı bulunmuştur. Rotavirüs antijen pozitifliğinin mevsimlere göre dağılımı incelendiğinde,sonbahar ve kış aylarında diğer aylara göre istatistiksel olarak anlamlı düzeyde yüksek bulunurken, adenovirüs antijen pozitifliğinin mevsimlere göre dağılımında anlamlı bir fark bulunmamıştır.Özellikle çocuklarda, gastroenterit etiyolojisinde adenovirüs ve rotavirüs göz ardı edilmemelidir. Bu nedenle, rotavirüs aşılaması, rotavirüse bağlı ishal vakalarının azaltılmasında; bu vakalara bağlı hastaneye yatışların, mortalite ve morbiditenin önlenmesinde ve hastalığın oluşturduğu ekonomik yükün hafifletilmesinde önemli bir önleme stratejisi olarak değerlendirilmelidir.

Keywords

• Adenovirüs
• gastroenterit
• rotavirüs.

Supporting Institution

Çalışma herhangi bir kurum ve kuruluş tarafından desteklenmemiştir.

Ethical Statement

Bu çalışma, Mersin Üniversitesi Rektörlüğü Klinik Araştırmalar Etik Kurulu tarafından, 31/01/2024 tarihli 2024/098 sayılı karar numarası ile onaylanmıştır.

Thanks

Mersin Üniversitesi Erdemli Uygulamalı Teknoloji ve İşletmecilik Bilimler Yüksekokulu Prof. Dr. Kalender Özcan ATILGAN’a teşekkür ederiz.

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