SIĞIRLARDA MANTAR HASTALIĞININ SAĞALTIMINDA NEGUVON VE WHİTFİELD’S MERHEMİN BİRLİKTE KULLANIMININ ETKİNLİĞİNİN ARAŞTIRILMASI

Abstract

Bu çalışmanın amacı, Kayseri yöresi genç sığırlarında trikofitozis (ringworm) sağaltımında Neguvon, Whitfield’s vemerhem etkinliğini araştırmaktır.Çalışmada yaşları 2-20 ay arasında değişen, farklı ırk ve cinsiyetlerde, klinik ve laboratuar muayenelerinde ringworm olduğu belirlenen toplam 35 hayvan kullanıldı. Bu hayvanların 5’ine herhangi bir tedavi uygulanmadı ve kontrol grup olarak belirlendi (Grup I). Hayvanlardan 10 adedine Neguvon pomat (Grup II), 10 adedine Whitfield’s merhem (Grup III) ve 10 adedine ise Neguvon+ Whitfield’s merhem 3’er gün arayla 5 kez uygulandı. Hayvanlar 15 gün aralıklarla 45 gün süresince takip edildi. Çalışma süresince kontrol grubundaki hayvanlarda herhangi bir iyileşme gözlenmedi (p>0.05). Grup II’de 10 hayvandan 7’si (%70), Grup III ve Grup IV’deki hayvanların tamamının (%100) iyileştiği belirlendi (p<0.05).6RQXo RODUDN VığıUODUGD ULQJZRUP VDğDOWıPıQGD Neguvon+Whitfield’s Neguvon ve Whitfield’s pomatların tek başına kullanılmasından daha etkili olduğu belirlendi

Keywords

• Sığır, Ringworm, Neguvon, Whitfield’s merhem

The Investigation of Efficacy of Neguvon-Whitfield’s Ointment Combinations for the Treatment of Ringworm in Cattle

Abstract

The purpose of this study is to investigate the effecicacy of Neguvon, Whitfield’s and Neguvon+Whitfield’s ointment for the treatment of young cattle with ringworm in Kayseri and vicinity. Used in this study were 35 young cattle between 2 and 20 months of age, different sex and breeds, diagnosed as ringworm following clinical and microbiological examinations. These cattle were allocated into four groups of 5 in Group I, 10 in each of Group II, III and IV. Group I served as a control group and received no treatment. As five times with on interval, of 3 days in between, the animals were topically administered Neguvon pomade (Group II), Whitfield’s ointment (Group III) and Neguvon+ Whitfield’s ointment (Group IV). The first drug applications were considered as the 0th day. Animals were monitored at an interval of 15 days up to the 45 day. No remission was observed in the control group (p>0.05). Seven out of ten animals (70%) in Group II and all animals (100%) in Group III and Group IV showed complete recovery during 45 days the observation period (p<0.05). It was concluded that Neguvon+ Whitfield’s ointment for the treatment of young cattle with ringworm is more effective than the Neguvon pomade or Whitfield’s ointment alone for the treatment of ringworm

Keywords

• Cattle, Ringworm, Neguvon, Whitfield’s ointment

References

1. Chermette R, Ferreiro L, Guillot J. Derma- WRSK\WRVHV LQ DQLPDOV 0\FRSDWKRORJLD 166:385-405
2. Gudding R, Lund A. Immunoprophylaxis of ERYLQH GHUPDWRSK\WRVLV &DQ 9HW - 302-306
3. Koçoğlu E, Karabay O, Kırmusaoğlu S. Yüze- yel mantar etkeni olarak izole edilen mantar- lar: iki yıllık verilerin değerlendirilmesi. Kli- mik XIII. Türk Klinik Mikrobiyoloji ve İnfeksi- yon Hastalıkları Kongresi, 2007 s.296
4. Dilek N, Yücel AY, Dilek AR, et all. Fırat Üni- versitesi Hastanesi Dermatoloji Kliniği’ne Başvuran Hastalardaki Dermatofitoz Etkenle- ri - 2ULMLQDO $UDşWıUPD - 'HUPDWRO 27-31
5. Vogler G. 6 per cent Neguvon suspension in trichophytosis of ruminants (ringworm and FDOI VFXUI :LHQ 7LHUDU]WO 0RQDWVVFKU 53: 51.
6. Pandey VS. Effect of thiabendazole and tinctu- re of iodine on cattle ringworm caused by Trichophyton verrucosum. Trop Anim Health 3URG -178.
7. Gabal MA. Study on the evaluation of the use of thiabendazole in the treatment and control of bovine dermatophytosis. Mycopathologia -68.
8. Başoğlu A, Birdane FM, Solmaz H. The effect of Henna (folium lawsoniae) paste in calves ZLWK ULQJZRUP ,QG 9HW -RXUQDO - 72.

9. Spanoghe L, Oldenkamp EP. Mycological and clinical observations on ringworm in cattle DIWHU WUHDWPHQW ZLWK QDWDP\FLQ 9HW 5HF 101: 135-6.
10. Al-Ani FK, Younes FA, Al-Rawasshden FO. Ringworm infection in cattle and horses in -RUGDQ $FWD 9HWHULQDULD %UQR - 60.
11. Cheesbrough M. Medical Laboratory Manual for Tropical Countries. Vol.2, Tropical Health Technology, Butterworth-Heinemann, Great Britain 1992 pp. 371-385.
12. Moriello KA. Diagnostic techniques for der- motophytes. Clin Tech Small Anim Pract -224.
13. Halley LD, Standard PG. Laboratory Methods in Medical Mycology.3th Ed. US Department of Health, Education and Welfare, Center of Disease Control, Atlanta pp 41-57.
14. Papini R, Nardoni S, Fanelli A, et all. High Infection Rate of Trichophyton verrucosum in Calves from Central Italy. Zoonoses Public +HDOWK -64.
15. Pandey VS, Cabaret J. The distribution of ringworm lesions in cattle naturally infected by Trichophyton verrucosum. Ann Rech Vet -84.
16. Khosravi AR, Mahmoudi M. Dermatophytes isolated from domestic animals in Iran. My- coses 46, 222-225.
17. Takatori K, Takahashi A, Kawai S, et all. Iso- lation of Trichophyton verrucosum from lesio- nal and non-lesional skin in calves. J Vet Med 6FL -344.
18. Caban˜es FJ, Abarca ML, Bragulat MR. Dermatophytes isolated from domestic animals in Barcelona, Spain. Mycopathologia -113.
19. Kırmızıgül AH, Gökçe E, Şahin M, et all. Der- matofitozisli sığırlarda enilconazole’ün (% 10’luk pour-on) etkinliği. Kafkas Üniv Vet )DN 'HUJ -144.
20. Stannard AA. Dermatophytosis. In: B. P. Smith(ed), Large Animal Internal Medicine. QG HGQ 3KLODGHOSKLD 0RVE\ SS - 1421.
21. Andrews AH, Edwardson J. Treatment of ringworm in calves using griseofulvin. Vet 5HF -500.
22. Yamauchi K, Hiruma M, Yamazaki N, et all. Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-EOLQG VWXG\ 0\FRVHV - 202.
23. Wakabayashi H, Uchida K, Yamauchi K, et all. Lactoferrin given in food facilitates der- matophytosis cure in guinea pig models. J $QWLPLFURE &KHPRWKHU -601.
24. Oldenkamp EP. Natamycin treatment of ringworm in cattle in the United Kingdom. Vet 5HF -5556.
25. Şanlı Y, Kaya S. Antelmintikler. In: Şanlı Y (ed), Veteriner Farmakoloji ve Ilaçla Sağaltım Seçenekleri. 1. Baskı, Feryal Matbaacılık, $QNDUD VV -674.
26. Gooskens V, Pönnighaus JM, Clayton Y, et all. Treatment of superficial mycoses in the tropics: Whitfield's ointment versus clotrima- ]ROH ,QW - 'HUPDWRO -42.