HÜCRE ADEZYON MOLEKÜLÜ: NEKTİN

Abstract

Adezyon molekülleri, birbirleriyle veya ekstraselüler gösteren, hücre-hücre ve hücre-ekstraselüler matriks bağlantısını sağlayan protein molekülleridir. Hücre adezyon molekülleri hücre aktivasyonu, göçü, büyümesi, farklılaşması ve ölümü gibi bir çok olayın düzenlenmesinde rol oynar. Nektin’ler Ca2+bağımsız immunoglobulin-benzeri hücre adezyon molekülüdür, nektin-1, nektin-2, nektin-3, ve nektin4 olmak üzere dört üyeden oluşan bir ailedir. Nektin’ler kaderinler’den bağımsız ya da kaderin işbirliği ile hareket ederek çeşitli hücre-hücre bağlantılarının oluşumuna katkıda bulunurlar ve homofilik ve heterofilik trans-etkileşimleri ile hücrehücre adezyonuna sebep olurlar. Nektin-1, nektin-2 ve nektin-3 fibroblastlar, epitelyal hücreler ve nöronları içeren çeşitli hücre tiplerinde eksprese edilmektedir. Nektin-4 ise başlıca plasentada eksprese edilmektedir. Bu derlemede nektin molekülünün morfolojik yapısı ve fonksiyonu anlatılmaktadır

Keywords

• Bağlantı kompleksleri, hücre adezyon molekülleri, nektin

Cell Adhesion Molecule: Nectin

Abstract

molecules, which interact with each other or the extracellular fluid molecules, cell-cell and cellextracellular matrix protein molecules that provide their connection. Cell adhesion molecules play a role in the regulation of many events such as cell activation, migration, proliferation, differentiation and immunoglobulin-like cell adhesion molecules which comprise a family of four members, nectin-1, nectin-2, nectin-3, and nectin-4. Nectins contribute to the formation of a variety of cell–cell junctions, acting cooperatively with or independently of cadherins and these cause cell-cell adhesionhomophilically and heterophilically trans-interact. Nectin-1, nectin-2 and nectin-3 are expressed in a variety of cells, including fibroblasts, epithelial cells and neurons. Human nectin-4 is expressed mainly in the placenta. In this review, morphologic structure and function of nectin molecule have been discussed

Keywords

• Junctional complex, cell adhesion molecules, nectin

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