Evaluatıon of Malondialdehyde Level and Paraoxonase 1 Activity in Obese Children

Abstract

The high prevalence of childhood obesity and related serious health consequences have received increasing attention in medical studies and health policies. Obesity is recognized as a risk factor for cardiovascular disease. Oxidative stress is a risk factor for endothelial disfunction in obese individuals. Therefore, we aim to evaluate paraoxonase 1 (PON1) activity with malondialdehyde (MDA) levels in obese children.Our study included 51 obese children and 40 healthy controls aged 6-15 years. Obesity was defined as a body mass index (BMI) ≥ 95th percentile for age and gender. While serum lipid profiles were analyzed by Siemens ADVİA 1800, PON1 activity and MDA were evaluated by spectrophotometric method. While triglyceride, total cholesterol and LDL-cholesterol levels were higher, HDL-cholesterol levels were lower in obese children than in controls (p < 0.05). On the other hand, we found that obese children had higher MDA levels and PON1 activities, but this was not significantly different in obese children. Although there is not a significant difference between oxidant and antioxidant parameters in obese children compared with control children, because of dyslipidemia they are recognized as risk factors for cardiovascular disease. Lifestyle changes and entertaining physical activity should be implemented as necessary strategies in managing childhood obesity and dyslipidemia

Keywords

• Childhood obesity, lipid profiles,BMI, MDA, PON1

OBEZ ÇOCUKLARDA MALONDİALDEHİT SEVİYESİ VE PARAOKSONAZ 1 AKTİVİTESİNİN DEĞERLENDİRİLMESİ

Abstract

Çocukluk obezitesi ve ilişkili olduğu ciddi sağlık sorunlarının artan hızı, tıbbi araştırmalarda ve sağlık politikalarında gittikçe daha çok ilgi çekmektedir. Obezite, kardiyovasküler hastalıklar için bir risk faktörü olarak bilinmektedir. Obez kişilerde oksidatif stres, endotel disfonksiyon için bir risk faktörüdür. Bu sebeple çalışmamızda obez çocuklarda paraoksonaz 1 (PON1) aktivitesi ile malondialdehit (MDA) seviyelerinin değerlendirilmesi amaçlanmıştır. Çalışmamıza yaşları 6-15 arasında olan 51 obez ve 40 sağlıklı çocuk alınmıştır. Obezite, yaş ve cinsiyet göz önüne alınarak, 95 persentil ve üzerindeki vücut kitle indeksi (VKİ) ile belirlendi. Serum lipit profili, Siemens ADVİA 1800 ile analiz edilirken, PON1 aktivitesi ve MDA düzeyleri spektrofotometrik metot ile değerlendirildi. Obez çocukların trigliserit, total kolesterol ve LDL-kolesterol seviyeleri kontrol grubundan anlamlı düzeyde yüksek, HDL-kolesterol seviyeleri anlamlı düzeyde düşüktü. Diğer taraftan obez çocuklarda PON1 aktivitesi ve MDA düzeyleri yüksek olmasına rağmen kontrol grubu ile karşılaştırıldığında anlamlı bir faklılık gözlenmedi. karşılaştırıldığı zaman oksidant-antioksidant parametreler açısından anlamlı düzeyde bir farklılık bulunmamasına rağmen, dislipidemi kardiyovasküler hastalıklar için bir risk faktörü olduğu için, çocukluk obezitesinin ve dislipideminin yönetimi için, yaşam biçimi değişiklikleri ve eğlenceli fiziksel aktivite gerekli stratejiler olarak uygulamaya konmalıdır

Keywords

• Çocukluk obezitesi, lipit profili,VKİ, MDA, PON1

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