SIĞIR PAPİLLOMATOZİSİNDE SAĞALTIM AMACIYLA UYGULANAN İVERMEKTİNİN SERUM TNF-α VE IL-6 DÜZEYLERİNE ETKİSİNİN BELİRLENMESİ

Abstract

Bu çalışmanın amacı, sığır papillomlarının tedavisinde kullanılan ivermektinin, serum TNF-α ve IL-6 üzerine olan etkisinin belirlenmesidir. Bu çalışmaya, klinik olarak papillomatozis olduğu belirlenen, yaşları 15-20 aylar arasında değişen, 9 hasta sığır (4’ü erkek Montofon, 3’ü dişi Montofon 1’i dişi Yerli kara, 1’i dişi Holştayn) dahil edildi. Tüm sığırlardan kan örnekleri alındıktan sonra, 0,2 mg/kg dozunda ivermektin, deri altı yol ile uygulandı. İlk uygulamayı takiben 7, 22 ve 52. günlerde kan alındıktan sonra klinik kontrolleri yapıldı. Çalışmaya dahil edilen hayvanlardan 4’ünde (1 Holştayn, 3 Montofon) papillomlarda %90-100 oranında gerileme belirlenirken, 2 hayvanda (2 Montofon) % 70-80 gerileme, diğer hayvanlarda (1 Yerli kara, 2 Montofon) ise herhangi bir gerileme olmadığı belirlendi. Alınan serum örneklerinde TNF-α ve IL-6 düzeylerinin ivermektin uygulamasını takiben 7. günde arttığı, 22 ve 52. günlerde ise giderek azaldığı, ancak bu değişimin istatistiksel olarak önemli olmadığı belirlendi (P>0,05). Sonuç olarak; sığır papillomatozisinde tedavi amacıyla uygulanan ivermektinin hayvanlarda iyileşmeye etkisi olduğu, serum TNF-α ve IL-6 düzeylerinde değişimler oluşturduğu belirlendi. Bu sonuçlara göre ivermektinin etki şekliyle ilgili daha kapsamlı çalışmalar yapılması gerektiği kanısına varıldı.

Keywords

• İvermektin, IL-6, Sığır papillomatozis, TNF-α

The Effect of Ivermectin on Serum Tnf-Α And Il-6 Levels In Bovine Papillomatosis

Abstract

This study aimed to evaluate the effects of the ivermectin used in the treatment of bovine papillomatosis on serum TNF-α and IL-6. Nine cattle with different ages (15-20 months old), breed (4 male Brown Swiss, 3 female Brown Swiss, 1 female Native Black, 1 female Holstein with clinically bovine papillomatosis were included. After taking blood samples from all animals, ivermectin at a dose of 0.2 mg/kg was administered subcutaneously as a single dose. On the 7, 22 and 52nd days after the first application, blood sampling and the monitoring of the animals were repeated. Four animals (1 Brown Swiss and 3 Brown Swiss) and two animals (2 Brown Swiss) regressed nearly 90-100 % and 70-80 %, respectively while in other animals (1 Native Black and 2 Brown Swiss) no remission was observed during the observation period. Serum TNF-α and IL-6 levels were determined to have increased on the 7th day and decreased on the 22nd and 52nd days following the administration, but no statistically significance (p>0.05). It was concluded that ivermectin might be effective on clinically recovery and serum TNF-α and IL-6 levels. More comprehensive future studies on higher numbers of animals are warranted.

Keywords

• Bovine papillomatosis IL-6, Ivermectin, TNF-α

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