EXOSOMES AND ITS RELATIONSHIP WITH NEURODEGENERATIVE DISEASES

Abstract

The new perspective that nanotechnology has created in the field of health and science has inspired the field of biotechnology by allowing DNA molecules to be examined developed and produced by special methods. With nanotechnological applications especially in drug delivery systems, the pharmacokinetics, pharmacodynamics and therapeutic indices of drugs have been improved, the drug has been released continuously and in a controlled manner, thereby reducing the side effects of the drug and it is aimed to show an effective bioavailability in targeted tissues and cells. With the advances achieved with the effective use of nanosized structures in biotechnology, the vesicular structures secreted from all kinds of cells and called extracellular vesicles have enabled exciting studies in the field of medicine and biology. Studies using transmembrane receptors of biomolecules and extracellular vesicles as communication tools in genetic information transfer have gained importance in recent years. For this reason, extracellular vesicles, which are now considered as natural liposomes of biotechnology, have gained importance in the diagnosis and treatment of diseases due to their biocompatibility and their easy availability.

Keywords

• Exosome
• nanotechnology
• neurodegenerative diseases.

EKSOZOMLAR VE NÖRODEJENERATİF HASTALIKLARLA İLİŞKİSİ

Abstract

Nanoteknolojinin sağlık ve fen bilimleri alanında oluşturduğu yeni bakış açısı, DNA moleküllerinin özel yöntemlerle incelenmesine, geliştirilmesine ve üretilmesine olanak sağlayarak, biyoteknoloji bilim dalına esin kaynağı olmuştur. Özellikle ilaç dağıtım sistemlerinde nanoteknolojik uygulamalar ile ilaçların farmakokinetiği, farmakodinamiği ve terapötik endeksleri geliştirilmiş, ilacın sürekli ve kontrollü salınımı sağlanmış ve bu sayede ilacın yan etkileri azaltılarak hedeflenen doku ve hücrelerde etkin bir biyo-yararlanım göstermesi hedeflenmiştir. Nano boyuttaki yapıların biyoteknolojideki etkin kullanımları ile elde edilen gelişmelerle birlikte, her türlü hücreden salgılanan ve hücre dışı veziküller olarak adlandırılan veziküler yapılar, tıp ve biyoloji alanında heyecan verici çalışmaların yapılmasına olanak sağlamıştır. Biyo-moleküllerin transmembran reseptörleri ve genetik bilgi aktarımında iletişim aracı olarak hücre dışı veziküllerin kullanıldığı çalışmalar son yıllarda oldukça önem kazanmıştır. Bu nedenle şimdilerde biyoteknolojinin doğal lipozomları olarak nitelendirilen hücre dışı veziküller, hastalıkların tanı ve tedavisinde hem biyo-uyumlulukları hem de kolay elde edilebilir olmaları sebebiyle oldukça önem kazanmıştır.

Keywords

• Eksozom
• Nörodejeneratif hastalıklar
• Nanoteknoloji

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