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COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS

Year 2022, , 301 - 306, 26.12.2022
https://doi.org/10.34108/eujhs.984365

Abstract

In this study, it was aimed to evaluate the mood differences between those with normal thyroid function test (TFT) and those with normal TFT in patients with hyperemesis gravidarum. Therefore, thyroid function tests of pregnant women who were diagnosed with hyperemesis gravidarum during the three-month study period were evaluated. Patients were divided into two groups according to normal and abnormal thyroid function tests. Each group consisted of 50 patients. The demographic characteristics of both groups were recorded and Beck depression and anxiety scales were applied to the groups. Although the Beck depression inventory score was 58% in pregnant women with normal TFT and 56% in non-normal patients, this difference was not statistically significant (p>0.05). According to Beck Anxiety Inventory scores, there was a statistically significant difference between patients with abnormal TFT and patients with normal TFT (p<0.05). Also, patients with abnormal TFT tended to be more anxious than those with normal TFT (p<0.1). A moderately strong negative correlation was found between Beck depression and Beck anxiety inventory scores in the patient group with abnormal TFT (Spearman's rho =-0.403; p=0.004). In addition, there was a weak negative correlation between Beck depression inventory score and social security status (Spearman's rho = -0.287; p=0.043), while a weak positive correlation was found between Beck depression inventory score and history of miscarriage (Spearman's rho = 0.287; p=0.043). In this study, although there was no significant difference in depression between patients with hyperemesis gravidarum with and without normal TFT, it was determined that anxiety levels were higher in patients with abnormal TFT compared to those with normal TFT.

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References

  • Mc Parlin C, O'Donnell A, Robson SC, et al. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review. JAMA 2016;316(13):1392-1401.
  • Glinoer D. Thyroid regulation and dysfunction in the pregnant patient. Thyroid 2004;14(3):234-45.
  • Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S. Fetal loss associated with excess thyroid hormone exposure. JAMA 2004;292(6):691-5.
  • Güler AE, Yıldız B, Çakmak B, Güler Z, Kıncı MF. Are Thyroid Functions Effective in Pregnant Women with Hyperemesis Gravidarum? Cerrahpaşa Medical Journal 2019; 43(3): 80-84.
  • Ferbeg MFG, Gillot DJ,Al-Fardan N, Grudzinskas JG. Hyperemesis Gravidarum, a literature review. Hum Reprod Update 2005;11(5):527-39.
  • Lazarus JH. Hyper thyroidism during pregnancy: etiology, diagnosis and management. Womens Health (Lond Engl) 2005;1:97-104.
  • Leunen M, Velkeniers B, Verlaenen H. Is there a relation ship between hyperemesis gravidarum and hyperthyroidism? Acta Clin Belg 2001;56:78-85.
  • Pirimoglu ZM, Guzelmeric K. PsychologicalFactors Of Hyperemesis Gravidarum By Using The Scl-90-R Questionnaire. Clin Exp Obstet Gynecol. 2010;37(1):56-9.
  • Navaneethakrishnan R,Lindow SW, Masson EA, Allan B. Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum-report of two cases. J Obstet Gynaecol 2004;24:774-5.
  • Rodien P, Jordan N, Lefèvre A, et al. Abnormal stimulation of the thyrotroph in receptor during gestation. Hum Reprod Update 2004;10:95-105.
  • Hisli N. Beck Depresyon Envanterinin geçerliği üzerine bir çalışma. Psikoloji Dergisi, 1988; 6(22): 118-122.
  • Aktürk Z, Dağdeviren N, Türe M, C Tuğlu. Birinci basamak için Beck Depresyon Tarama Ölçeği’nin Türkçe Çeviriminin geçerlilik ve güvenilirliği Türk Aile Hekimliği Dergisi 2005;9(3):117-122.
  • Ulusoy M, Şahin N, Erkman H. Turkish Version of The Beck anxiety inventory: psychometric properties. J Cognitive Psychotherapy: Int Quaterly. 1998;12:28-35.
  • Zimmerman CF, Ilstad-Minnihan AB, Bruggeman BS, Bruggeman BJ, Dayton KJ, Joseph N, Moas DI, Rohrs HJ. Thyroid Storm Caused by Hyperemesis Gravidarum. AACE Clin Case Rep. 2022, 3;8(3):124-127.
  • Goodwin TM. Hyperemesis gravidarum: Obstetrics and Gynecology Clinics of North America Obstet Gynecol Clin North Am. 2008;35(3):401-17.
  • Leunen M, Velkeniers B, Verlaenen H. Is there a relationship between hyperemesis gravidarum and hyper thyroidism? Acta Clin Belg 2001; 56: 78-85.
  • Deruelle P, Dufour P, Subtil D, et al. Hyperemesis in the first trimester of pregnancy: role of biological hyper thyroidism and fetal sex. Gynecol Obstet Fertil 2002; 30: 204-9.
  • Şimşek Y, Çelik Ö, Yılmaz E, et al. Assessment of anxiety and depression levels of pregnant women with hyperemesis gravidarum in a case-control study. J Turkish-German Gynecol Assoc 2012;13(1):32-6.
  • Hızlı D, Kamalak Z, Kosus A, et al. Hyperemesis gravidarum and depression in pregnancy: is there an association? J Psychosom Obstet Gynaecol 2012;33(4):171-5.
  • Swallow BL, Lindow SW, Masson EA, Hay DM. Psychological health in early pregnancy: Relationship withnausea and vomiting. J Obstet Gynaecol 2004;24(1):28-32.
  • Öz İş, Boran AB, Ateşer G, Bacanakgil BH, Yıldırım SG. Hiperemezis gravidarumlu gebelerde psikolojik belirti taraması: Batı Karadeniz Tıp Dergisi 2017;1:76-83.
  • Uğuz F, Gezginc K, Kayhan F, Erdinç C, Kantarci AH. Is hyperemesis gravidarum associated with mood, anxiety and personality disorders: a case-control study. Gen Hosp Psychiatry 2012;34(4):398-402.
  • Simpson SW, Goodwin TM, Robins SB, et al. Psychological factors and hyperemesis gravidarum. J Womens Health Gend Based Med 2001;10(5):471-7.
  • Annagur BB, Tazegul A, Gunduz S. Do psychiatric disorders continue during pregnancy in women with hyperemezis gravidarum: a prospective study. General Hospital Psychiatry. 2013; 35: 492-6.

HİPEREMEZİS GRAVİDARUM HASTALARINDA TİROİD FONKSİYON TESTLERİ NORMAL OLANLAR VE TİROİD FONKSİYON TESTLERİ NORMAL OLMAYANLAR ARASINDAKİ DUYGU DURUM KARŞILAŞTIRILMASI

Year 2022, , 301 - 306, 26.12.2022
https://doi.org/10.34108/eujhs.984365

Abstract

Bu çalışmada hiperemezis gravidarum hastalarında tiroid fonksiyon testi(TFT) normal olanlar ve TFT’i normal olmayanlar arasındaki duygu durum farklılıklarının değerlendirilmesi amaçlanmıştır. Bu nedenle üç aylık çalışma döneminde hiperemezis gravidarum tanısı alan gebelerin tiroid fonksiyon testleri değerlendirildi. Hastalar normal ve anormal tiroid fonksiyon testlerine gore iki gruba ayrıldı. Her grup 50 hastadan oluşuyordu. Her iki grubunda demografik özellikleri kayıtedilerek gruplara Beck depresyon ve anksiyete ölçekleri uygulandı. Beck depresyon envanteri puanı TFT’i normal olan gebelerde %58, normal olmayanlarda %56 olmasına rağmen bu fark istatistiksel olarak anlamlı değildi (p>0.05). Beck Anksiyete Envanteri puanlarına göre anormal TFT'si olan hastalar ile normal TFT'si olan hastalararasında istatistiksel olarak anlamlı fark vardı (p<0.05). Ayrıca anormal TFT'si olan hastalar, normal TFT'si olanlara gore daha endişeli olma eğilimindeydi (p<0.1). Anormal TFT'I olan hasta grubunda Beck depresyon ile Beck anksiyete envanteri puanları arasında orta kuvvette negative korelasyon tespit edildi (Spearman's rho =-0.403; p=0.004). İlave olarak Beck depresyon envanteri puanı ile sosyal güvenlik durumu arasında zayıf bir negative ilişki bulunurken (Spearman's rho = -0.287; p=0.043), Beck depresyon envanteri puanı ile düşük öyküsü arasında zayıf bir pozitif korelasyon tespit edilmiştir (Spearman's rho = 0.287; p=0.043). Bu çalışmada TFT’i normal olan ve olmayan hiperemezis gravidarumlu hastalararasında depresyon açısından anlamlı bir fark olmadığı halde, TFT’i normal olmayanlarda, normal olanlara kıyasla kaygı düzeylerinin daha yüksek olduğu belirlenmiştir.

Project Number

No Project Number

References

  • Mc Parlin C, O'Donnell A, Robson SC, et al. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review. JAMA 2016;316(13):1392-1401.
  • Glinoer D. Thyroid regulation and dysfunction in the pregnant patient. Thyroid 2004;14(3):234-45.
  • Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S. Fetal loss associated with excess thyroid hormone exposure. JAMA 2004;292(6):691-5.
  • Güler AE, Yıldız B, Çakmak B, Güler Z, Kıncı MF. Are Thyroid Functions Effective in Pregnant Women with Hyperemesis Gravidarum? Cerrahpaşa Medical Journal 2019; 43(3): 80-84.
  • Ferbeg MFG, Gillot DJ,Al-Fardan N, Grudzinskas JG. Hyperemesis Gravidarum, a literature review. Hum Reprod Update 2005;11(5):527-39.
  • Lazarus JH. Hyper thyroidism during pregnancy: etiology, diagnosis and management. Womens Health (Lond Engl) 2005;1:97-104.
  • Leunen M, Velkeniers B, Verlaenen H. Is there a relation ship between hyperemesis gravidarum and hyperthyroidism? Acta Clin Belg 2001;56:78-85.
  • Pirimoglu ZM, Guzelmeric K. PsychologicalFactors Of Hyperemesis Gravidarum By Using The Scl-90-R Questionnaire. Clin Exp Obstet Gynecol. 2010;37(1):56-9.
  • Navaneethakrishnan R,Lindow SW, Masson EA, Allan B. Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum-report of two cases. J Obstet Gynaecol 2004;24:774-5.
  • Rodien P, Jordan N, Lefèvre A, et al. Abnormal stimulation of the thyrotroph in receptor during gestation. Hum Reprod Update 2004;10:95-105.
  • Hisli N. Beck Depresyon Envanterinin geçerliği üzerine bir çalışma. Psikoloji Dergisi, 1988; 6(22): 118-122.
  • Aktürk Z, Dağdeviren N, Türe M, C Tuğlu. Birinci basamak için Beck Depresyon Tarama Ölçeği’nin Türkçe Çeviriminin geçerlilik ve güvenilirliği Türk Aile Hekimliği Dergisi 2005;9(3):117-122.
  • Ulusoy M, Şahin N, Erkman H. Turkish Version of The Beck anxiety inventory: psychometric properties. J Cognitive Psychotherapy: Int Quaterly. 1998;12:28-35.
  • Zimmerman CF, Ilstad-Minnihan AB, Bruggeman BS, Bruggeman BJ, Dayton KJ, Joseph N, Moas DI, Rohrs HJ. Thyroid Storm Caused by Hyperemesis Gravidarum. AACE Clin Case Rep. 2022, 3;8(3):124-127.
  • Goodwin TM. Hyperemesis gravidarum: Obstetrics and Gynecology Clinics of North America Obstet Gynecol Clin North Am. 2008;35(3):401-17.
  • Leunen M, Velkeniers B, Verlaenen H. Is there a relationship between hyperemesis gravidarum and hyper thyroidism? Acta Clin Belg 2001; 56: 78-85.
  • Deruelle P, Dufour P, Subtil D, et al. Hyperemesis in the first trimester of pregnancy: role of biological hyper thyroidism and fetal sex. Gynecol Obstet Fertil 2002; 30: 204-9.
  • Şimşek Y, Çelik Ö, Yılmaz E, et al. Assessment of anxiety and depression levels of pregnant women with hyperemesis gravidarum in a case-control study. J Turkish-German Gynecol Assoc 2012;13(1):32-6.
  • Hızlı D, Kamalak Z, Kosus A, et al. Hyperemesis gravidarum and depression in pregnancy: is there an association? J Psychosom Obstet Gynaecol 2012;33(4):171-5.
  • Swallow BL, Lindow SW, Masson EA, Hay DM. Psychological health in early pregnancy: Relationship withnausea and vomiting. J Obstet Gynaecol 2004;24(1):28-32.
  • Öz İş, Boran AB, Ateşer G, Bacanakgil BH, Yıldırım SG. Hiperemezis gravidarumlu gebelerde psikolojik belirti taraması: Batı Karadeniz Tıp Dergisi 2017;1:76-83.
  • Uğuz F, Gezginc K, Kayhan F, Erdinç C, Kantarci AH. Is hyperemesis gravidarum associated with mood, anxiety and personality disorders: a case-control study. Gen Hosp Psychiatry 2012;34(4):398-402.
  • Simpson SW, Goodwin TM, Robins SB, et al. Psychological factors and hyperemesis gravidarum. J Womens Health Gend Based Med 2001;10(5):471-7.
  • Annagur BB, Tazegul A, Gunduz S. Do psychiatric disorders continue during pregnancy in women with hyperemezis gravidarum: a prospective study. General Hospital Psychiatry. 2013; 35: 492-6.
There are 24 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

İsa Şükrü Öz 0000-0001-8849-2705

Özden Kutlay 0000-0001-5509-6650

Project Number No Project Number
Publication Date December 26, 2022
Submission Date August 18, 2021
Published in Issue Year 2022

Cite

APA Öz, İ. Ş., & Kutlay, Ö. (2022). COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS. Sağlık Bilimleri Dergisi, 31(3), 301-306. https://doi.org/10.34108/eujhs.984365
AMA Öz İŞ, Kutlay Ö. COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS. JHS. December 2022;31(3):301-306. doi:10.34108/eujhs.984365
Chicago Öz, İsa Şükrü, and Özden Kutlay. “COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS”. Sağlık Bilimleri Dergisi 31, no. 3 (December 2022): 301-6. https://doi.org/10.34108/eujhs.984365.
EndNote Öz İŞ, Kutlay Ö (December 1, 2022) COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS. Sağlık Bilimleri Dergisi 31 3 301–306.
IEEE İ. Ş. Öz and Ö. Kutlay, “COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS”, JHS, vol. 31, no. 3, pp. 301–306, 2022, doi: 10.34108/eujhs.984365.
ISNAD Öz, İsa Şükrü - Kutlay, Özden. “COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS”. Sağlık Bilimleri Dergisi 31/3 (December 2022), 301-306. https://doi.org/10.34108/eujhs.984365.
JAMA Öz İŞ, Kutlay Ö. COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS. JHS. 2022;31:301–306.
MLA Öz, İsa Şükrü and Özden Kutlay. “COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS”. Sağlık Bilimleri Dergisi, vol. 31, no. 3, 2022, pp. 301-6, doi:10.34108/eujhs.984365.
Vancouver Öz İŞ, Kutlay Ö. COMPARISON OF EMOTIONAL STATE IN HYPEREMESIS GRAVIDARUM PATIENTS WITH AND WITHOUT NORMAL THYROID FUNCTION TESTS. JHS. 2022;31(3):301-6.