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Two Oligodontia Cases Without Genetic Anomaly

Year 2007, Volume: 16 Issue: 3, 180 - 185, 01.12.2007

Abstract

Although congenital tooth agenesis is a common dental finding, oligodontia is a rare developmental dental anomaly associated with tooth number. Oligodontia, defined as the congenital absence of six or more teeth. Excluding the third molars, is commonly associated with syndromes and systemic abnormalities. Genetic factors may play an important role in oligodontia which may occur as part of a syndrome or as an isolated finding. This report presents two cases of oligodontia, 19 and 15 years, made certain after genetic consultation not to be associated with any syndromes or systemic abnormalities. In the first case only 16 teeth were present in the mouth and most of their shapes were microdont. In the intra oral examination of the second case only 5 permanent teeth were deteced and the panoramic radiograph showed 23 missing permanent teeth except third molars

References

  • White SC, Pharoah MJ. Dental anomalies. In: Oral Radiology, Principles and Interpretation (5th ed). Mosby, Missouri 2004, pp 330-365.
  • Sisman Y, Uysal T, Gelgor I. Hypodontia. Does the prevalence and distribution pattern differ in orthodontic patients? Eur J Dent 2007, 1:167-173.
  • Neville WB, Damm DD, Allen MC, Bouquot EJ. Oral and Maxillofacial Pathology. WB Saunders Co, Philadelphia 1995, pp 61-64.
  • Tsai PF, Chiou HR, Tseng CC. Oligodontia-a case report. Quintessence Int 1998, 29:191- 193.
  • Ng'ang'a RN, Ng'ang'a PM. Hypodontia of permanent teeth in a Kenyan population. East Afr Med J 2001, 78:200-203.
  • Ben-Bassat Y, Brin I. Skeletodental patterns in patients with multiple congenitally missing teeth. Am J Orthod Dentofacial Orthop 2003, 124:521-525.
  • Tavajohi-Kermani H, Kapur R, Sciote JJ. Tooth agenesis and craniofacial morphology in an orthodontic population. Am J Orthod Dentofacial Orthop 2002, 122:39-47.
  • Gelgör İE, Şişman Y, Malkoç S. Daimi denti- syonda Konjenital Hipodontinin görülme sık- lığı. Türkiye Klinikleri J Dental Sci 2005, 11:43-48.
  • Hobkirk JA, Brook AH. The management of patients with severe hypodontia. J Oral Reha- bil 1980, 7:289-298.
  • Grahnen H., Granath L. Numerical variations in primary dentition and their correlation with the permanent dentition. Odont Rev 1961, 12:348-357.
  • Brook AH. A unifiying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 1984, 29:373-378.
  • Näsman M, Forsberg CM, Dahllöf G. Long- term dental development in children after treatment for malignant disease. Eur J Orthod 1997, 19:151–159.
  • Semina EV, Reiter R, Leysens NJ, et al. Clon- ing and characterization of a novel bicoid- related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet 1996, 4:392–399.
  • Jumlongras D, Bei M, Stimson JM, et al. A nonsense mutation in MSX1 causes Witkop syndrome. Am J Hum Genet 2001, 69:67–74.
  • Ahmad W, Brancolini V, Ul Faiyaz MF, et al. A locus for autosomal recessive hypodontia with associated dental anomalies maps to chromosome 16q12.1. Am J Hum Genet 1998, 62:987–91.
  • Erpenstein H, Pfeiffer RA. Sex-linked dominant hereditary reduction in number of teeth. Humangenetik 1967, 4:280–293.
  • Lammi L, Arte S, Somer M, et al. Mutations in AXIN2 cause familial tooth agenesis and pre- dispose to colorectal cancer. Am J Hum Genet 2004, 74:1043–1050.
  • Schalk-van der Weide Y, Beemer FA, Faber JA, Bosman F. Symptomatology of patients with oligodontia. Oral Rehabil 1994, 21:247- 261.
  • Hattab FN, Angmar-Mansson B. Oligodontia of the permanent dentition in two sisters with polycystic ovarian syndrome: case reports. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997, 84:368-371.
  • Grahnen H. Hypodontia in the permanent den- tition, clinical and genetical investigation. Odont Rev 1956, 3:1-100.
  • Brook AH, Ekanayake NO. The etiology of oligodontia: a family history. ASDC J Dent Child 1980, 47:32-35.
  • Gedik R. Hypodontia and Oligodontia. Balk J Stom 2002, 6:150-151.
  • Salama FS, Abdel-Megid FY. Hypodontia of primary and permanent teeth in a sample of Saudi children. Egypt Dent J 1994, 40:625- 632.
  • Rolling S. Hypodontia of permanent teeth in Danish schoolchildren. Scand J Dent Res 1980, 88:365-369.
  • Stewart RE, Barner TK, Wei SHY. Pedaitric Dentistry. Scientific Foundations and Clinical Practice. Mosby, St Louis 1982, pp 87-109.

GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU

Year 2007, Volume: 16 Issue: 3, 180 - 185, 01.12.2007

Abstract

Konjenital diş eksikliği çok sık görülmesine rağmen, oligodonti nadir rastlanılan gelişimsel bir diş sayı anomalisidir. Üçüncü molar dişler sayılmaksızın, konjenital olarak altı veya daha fazla dişin eksikliği olarak tanımlanan oligodonti, genellikle sendromlar ve sistemik anomaliler ile ilişkilidir. Oligodontide genetik faktörler sendromların bir parçası olarak veya tek başına bir bulgu olarak önemlidir. Çalışmada, genetik değerlendirme sonucu herhangi bir sendromla ilişkili olmadığı saptanan 15 ve 19 yaşlarındaki iki oligodonti olgusu sunulmaktadır. Olgulardan birinde ağızda sadece 16 adet diş bulunduğu ve bu dişlerin çoğunun mikrodonti şeklinde olduğu belirlendi. İkinci olgunun yapılan intraoral muayenesinde sadece 5 adet daimi dişin mevcut olduğu gözlendi. Alınan panoramik radyograf ile üçüncü molar dişler hariç 23 adet daimi dişin eksik olduğunu tespit edildi

References

  • White SC, Pharoah MJ. Dental anomalies. In: Oral Radiology, Principles and Interpretation (5th ed). Mosby, Missouri 2004, pp 330-365.
  • Sisman Y, Uysal T, Gelgor I. Hypodontia. Does the prevalence and distribution pattern differ in orthodontic patients? Eur J Dent 2007, 1:167-173.
  • Neville WB, Damm DD, Allen MC, Bouquot EJ. Oral and Maxillofacial Pathology. WB Saunders Co, Philadelphia 1995, pp 61-64.
  • Tsai PF, Chiou HR, Tseng CC. Oligodontia-a case report. Quintessence Int 1998, 29:191- 193.
  • Ng'ang'a RN, Ng'ang'a PM. Hypodontia of permanent teeth in a Kenyan population. East Afr Med J 2001, 78:200-203.
  • Ben-Bassat Y, Brin I. Skeletodental patterns in patients with multiple congenitally missing teeth. Am J Orthod Dentofacial Orthop 2003, 124:521-525.
  • Tavajohi-Kermani H, Kapur R, Sciote JJ. Tooth agenesis and craniofacial morphology in an orthodontic population. Am J Orthod Dentofacial Orthop 2002, 122:39-47.
  • Gelgör İE, Şişman Y, Malkoç S. Daimi denti- syonda Konjenital Hipodontinin görülme sık- lığı. Türkiye Klinikleri J Dental Sci 2005, 11:43-48.
  • Hobkirk JA, Brook AH. The management of patients with severe hypodontia. J Oral Reha- bil 1980, 7:289-298.
  • Grahnen H., Granath L. Numerical variations in primary dentition and their correlation with the permanent dentition. Odont Rev 1961, 12:348-357.
  • Brook AH. A unifiying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 1984, 29:373-378.
  • Näsman M, Forsberg CM, Dahllöf G. Long- term dental development in children after treatment for malignant disease. Eur J Orthod 1997, 19:151–159.
  • Semina EV, Reiter R, Leysens NJ, et al. Clon- ing and characterization of a novel bicoid- related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet 1996, 4:392–399.
  • Jumlongras D, Bei M, Stimson JM, et al. A nonsense mutation in MSX1 causes Witkop syndrome. Am J Hum Genet 2001, 69:67–74.
  • Ahmad W, Brancolini V, Ul Faiyaz MF, et al. A locus for autosomal recessive hypodontia with associated dental anomalies maps to chromosome 16q12.1. Am J Hum Genet 1998, 62:987–91.
  • Erpenstein H, Pfeiffer RA. Sex-linked dominant hereditary reduction in number of teeth. Humangenetik 1967, 4:280–293.
  • Lammi L, Arte S, Somer M, et al. Mutations in AXIN2 cause familial tooth agenesis and pre- dispose to colorectal cancer. Am J Hum Genet 2004, 74:1043–1050.
  • Schalk-van der Weide Y, Beemer FA, Faber JA, Bosman F. Symptomatology of patients with oligodontia. Oral Rehabil 1994, 21:247- 261.
  • Hattab FN, Angmar-Mansson B. Oligodontia of the permanent dentition in two sisters with polycystic ovarian syndrome: case reports. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997, 84:368-371.
  • Grahnen H. Hypodontia in the permanent den- tition, clinical and genetical investigation. Odont Rev 1956, 3:1-100.
  • Brook AH, Ekanayake NO. The etiology of oligodontia: a family history. ASDC J Dent Child 1980, 47:32-35.
  • Gedik R. Hypodontia and Oligodontia. Balk J Stom 2002, 6:150-151.
  • Salama FS, Abdel-Megid FY. Hypodontia of primary and permanent teeth in a sample of Saudi children. Egypt Dent J 1994, 40:625- 632.
  • Rolling S. Hypodontia of permanent teeth in Danish schoolchildren. Scand J Dent Res 1980, 88:365-369.
  • Stewart RE, Barner TK, Wei SHY. Pedaitric Dentistry. Scientific Foundations and Clinical Practice. Mosby, St Louis 1982, pp 87-109.
There are 25 citations in total.

Details

Other ID JA72GH33VA
Journal Section Research Article
Authors

Yıldıray Şişman This is me

Elif Tarim Ertaş This is me

Munis Dündar This is me

Publication Date December 1, 2007
Submission Date December 1, 2007
Published in Issue Year 2007 Volume: 16 Issue: 3

Cite

APA Şişman, Y., Ertaş, E. T., & Dündar, M. (2007). GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU. Sağlık Bilimleri Dergisi, 16(3), 180-185.
AMA Şişman Y, Ertaş ET, Dündar M. GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU. JHS. December 2007;16(3):180-185.
Chicago Şişman, Yıldıray, Elif Tarim Ertaş, and Munis Dündar. “GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU”. Sağlık Bilimleri Dergisi 16, no. 3 (December 2007): 180-85.
EndNote Şişman Y, Ertaş ET, Dündar M (December 1, 2007) GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU. Sağlık Bilimleri Dergisi 16 3 180–185.
IEEE Y. Şişman, E. T. Ertaş, and M. Dündar, “GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU”, JHS, vol. 16, no. 3, pp. 180–185, 2007.
ISNAD Şişman, Yıldıray et al. “GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU”. Sağlık Bilimleri Dergisi 16/3 (December 2007), 180-185.
JAMA Şişman Y, Ertaş ET, Dündar M. GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU. JHS. 2007;16:180–185.
MLA Şişman, Yıldıray et al. “GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU”. Sağlık Bilimleri Dergisi, vol. 16, no. 3, 2007, pp. 180-5.
Vancouver Şişman Y, Ertaş ET, Dündar M. GENETİK ANOMALİSİ OLMAYAN İKİ OLİGODONTİ OLGUSU. JHS. 2007;16(3):180-5.