POSTOPERATİF BULANTI-KUSMANIN ÖNLENMESİNDE TROPİSETRON VE METOKLOPRAMİDİN ETKİLERİNİN KARŞILAŞTIRILMASI

Year 2009, Volume: 18 Issue: 1, 10 - 17, 01.03.2009

Nedim Çekmen Mustafa Arslan Mehmet Akçabay

Abstract

Özet : Çalışmamızda genel anestezi altında tiroidektomi
operasyonu geçirecek hastalarda (n=40) postoperatif
bulantı-kusma (POBK)’nın önlenmesinde tropisetronun
etkinliği metoklopramid ile karşılaştırıldı. Randomize
çift-kör çalışmamızda; American Society of
Anesthesiologists (ASA) I-II sınıflandırmasına göre 18-
70 yaş arası 40 hasta 20’şer kişilik iki gruba ayrıldı.
Metoklopramid grubu (Grup M)’na indüksiyondan önce
iv 10 mg metoklopramid ve tropisetron grubu (Grup
T)’na iv 2 mg tropisetron verildi. Bütün hastalara
standart genel anestezi uygulandı. İlaçların antiemetik
etkileri ve yan etkileri, her iki gruptaki antiemetik
gereksinimi 24 saat boyunca değerlendirildi. Grupların
bulantı-kusma skoru açısından karşılaştırılmasında
Grup T’de Grup M’ye göre bulantı-kusma skoru sıfır
olan hasta sayısı istatistiksel olarak anlamlı şekilde
yüksekti (p=0.027), diğer skorlar için gruplar arası
istatistiksel olarak anlamlı fark bulunmadı. Bulantıkusma görülme sıklığı her iki grupta benzerdi. Yan etkiler
açısından gruplar arası istatistiksel olarak anlamlı fark
belirlenemedi.
Tiroidektomi geçiren hastalarda POBK’yı önlemede
genel anestezi indüksiyonu öncesi 2 mg iv tropisetron
uygulandığında 24 saat boyunca POBK riskinin
metoklopramide göre daha az olduğu, dolayısıyla
tropisetronun uzun etkili bir antiemetik ajan olarak
POBK’nın önlenmesinde kullanılabileceği sonucuna
varıldı.

Keywords

Postoperatif bulantı-kusma (POBK), tropisetron, metoklopramid, tiroidektomi

Comparison of the Effects of Tropisetron and Metoclopramid in Prevention of Postoperative Nausea and Vomiting

Abstract

Summary: This study compared the efficacy of
tropisetrone and metoclopramide in preventing
postoperative nausea-vomiting (PONV) of the patients
(n=40) who underwent thyroidectomy under general
anesthesia. In our randomized double-blind study, 40
patients (between the age 18-70 years) who were
classified in American Society of Anesthesiologists
(ASA) I and II groups were classified into two groups,
with 20 patients in each. Before induction, 10 mg
metoclopramide was administered to metoclopramide
group (Group M), while 2 mg tropisetrone was
administered to tropisetrone group (Group T)
intravenously. All patients had standard general
anesthesia. Antiemetic and side effects of the drugs,
and the antiemetic requirements of the patients in both
groups were followed up for 24 hours. When
postoperative nausea-vomiting scores of the groups
were compared, the number of the patients with a
score of 0 was statistically significantly higher in
Group M than in Group T (p=0.027), and no
differences were detected among the other scores. The
frequency of nausea-vomiting was almost the same in
both groups. There were no statistically significant
differences between the groups for side effects. The
results of this study indicated that 2 mg intravenous
tropisetron application before induction of general
anesthesia in thyroidectomy patients prevents
postoperative nausea-vomiting better than
metoclopramide in 24-hour period. In conclusion,
tropisetrone may be used as a long-lasting antiemetic
drug to prevent postoperative nausea-vomiting

Keywords

Postoperative nausea and vomiting (PONV), tropisetron, metoclopramide, thyroidectomy

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