TAVŞAN TİBİALARINA UYGULANAN DENTAL İMPLANTLARIN BİYOMEKANİĞİNİN İNCELENMESİ YÖNTEMİNİN DEĞERLENDİRİLMESİ

Year 2009, Volume: 18 Issue: 3, 148 - 153, 01.12.2009

Arzu Alkan Samet İnal Alper Alkan

Abstract

Bu çalışmanın amacı, osteoporotik tavşanların tibialarına yerleştirilen titanyum implantların biyomekanik özelliklerini tarafımızdan geliştirilen bir ters tork manometre cihazı kullanarak incelemektir. Çalışmada kullanılan altı adet tavşan gelişigüzel olarak bilateral overektomi uygulanan (BO, n:2), bilateral overektomi uygulanan ve östrojen reseptör modülatörü olan raloksifen HCL verilen (BO+ÖRM, n:2) ve Sham overektomi uygulanan kontrol grubu (K, n:2) olmak üzere üç gruba ayrıldılar. Overektomi sonrası 6. haftanın sonunda her üç gruptaki deneklerin tibialarının metafiz bölgelerine standart boy ve çaptaki toplam 12 adet silindirik implant yerleştirildi. BO+ÖRM grubundaki deneklerin her birine her gün oral gavaj yoluyla olmak üzere 12 hafta süresince bir östrojen reseptör modülatörü olan raloksifen HCL (20 mg/kg/gün) verildi. İmplant cerrahisinden 12 hafta sonra sakrifiye edilen deneklerin tibiaları çıkarılarak akril bloklara gömüldü ve tarafımızdan geliştirilen bir ters tork manometre kullanılarak biyomekanik analizleri yapıldı. manometre cihazının yükün sadece kemik-implant ara yüzüne aksedeceği şekilde yeniden tasarlanması gerektiği sonucuna varılmıştır

Keywords

Dental implant, osteoporoz, ters tork testi

The Evaluation of the Method Used to Investigate the Biomechanics of Dental Implants Inserted in the Tibias of the Rabbits

Abstract

The aim of this study was to examine the biomechanics of titanium implants inserted in the tibias of osteoporotic rabbbits by using a reverse torque manometer recently developed by the authors. Six rabbits were randomly divided into three groups: bilateral overectomized (BO, n:2), bilateral overectomized and treated with estrogen receptor modulator, raloxifene HCL (BO+ORM, n: 2) and Sham overectomized control group (C, n: 2). At week six, following overectomy, 12 implants with standard length and diameters were placed in the metaphysis of the rabbit tibias in all the three groups. Raloxifen HCL was given (20 mg/kg/day) by oral gavage for a period of 12 weeks to the rabbits in BO+ORM group. After the sacrification of the animals 12 weeks following implant surgery, rabbit tibias were embedded into the acrylic blocks and biomechanical analysis was performed by using the reverse torque manometer developed by the authors. The reverse torque manometer should be re-developed in such a way that the load is transferred only to the bone-implant interface

Keywords

Dental implant, osteoporosis, reverse torque test

References

• Tresguerres IF, Clemente C, Donado M, Gómez-Pellico L, Blanco L, Alobera MA, Tresguerres JA. Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model. Clin Oral Implants Res 2002; 6: 631-636.
• Fujimoto T, Niimi A, Sawai T, Ueda M. Effects of steroid-induced osteoporosis on osseointegration of titanium implants. Int J Oral Maxillofac Implants 1998; 13:183-189.
• Eder A, Watzek G. Treatment of a patient with severe osteoporosis and chronic polyarthritis with fixed implant-supported prosthesis: a case report. Int J Oral Maxillofac Implants 1999; 14:587-590.
• Bianchi A, Sanfilippo F. Osteoporosis: the effect on mandibular bone resorption and therapeutic possibilities by means of implant prostheses. Int J Periodontics Restorative Dent 2002; 22: 231-239.
• Von Wovern N. ITI implants with overdentures: A prevention of bone loss in edentulous mandibles. Int J Oral Maxillofac Implants 199; 5: 135-139.
• Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 1991; 15:175-91.
• Gilsanz V, Roe TF, Gibbens DT, et al. Effect of sex steroids on peak bone density of growing rabbits. Am J Physiol 1988; 255: E416-421.
• Heringa M. Review on raloxifene: profile of a selective estrogen receptor modulator. Int J Clin Pharmacol Ther 2003; 41: 331-345.
• Jividen G Jr, Misch CE. Reverse torque testing and early loading failures: help or hindrance? J Oral Implantol 2000; 26: 82-90.