SIĞIRLARDA AKUT FAZ PROTEİNLERİ VE KLİNİK KULLANIM ALANLARI

Year 2011, Volume: 20 Issue: 3, 240 - 246, 01.12.2011

Alparslan Coşkun İsmail Şen

Abstract

Akut faz cevap; travma, stres, yangı veya enfeksiyon gibi zararlı etkenlere maruz kalınması sonucu vücutta gelişen bir tepkidir ve akut faz proteinler bu tepkinin bir parçasını oluşturur. Akut faz proteinler; hastalıkların takibi, şiddetinin değerlendirilmesi ve prognozunun belirlenmesi amacıyla veteriner ve beşeri alanda çok sayıda araştırmada kullanılmıştır. Bu derlemede son zamanlarda sığırlar üzerinde yapılan çalışmaların sonuçları üzerinde durulmuştur

Keywords

Akut faz protein, sığır

Clinical Use of Acute Phase Proteins in Cattle

Abstract

The acute phase response is an innate response activated by harmful stimuli such as inflammation, tissue damage, infection and bacterial component. Over the last few years, acute phase proteins have become the biomarkers of choice for monitoring inflammation and infection for diagnostic and prognostic purposes in veterinary medicine. This review focuses on features of the acute phase protein biomarkers currently used in cattle

Keywords

Acute phase proteins, cattle

References

• Turgut K. Veteriner Klinik Laboratuvar Teş- his. Bahçıvanlar Basımsanayi, Konya 2000; ss 489-505.
• Tiftik AM. Klinik Biyokimya,Mimoza AŞ Kon- ya, 1996
• Murata H, Shimada N, Yoshioka M. Current research on acute phase proteins in veterinary diagnosis. Vet J 2004; 168:28-40.
• Petersen HH, Nielsen JP, Heegaard PMH. Application of acute phase protein measurement in veterinary clinical chemistry. Vet Res 2004; 35:163–187.
• Eckersall PD. The time is right for acute phase protein assay. Vet J 2004; 168:3-5.
• Eckersall PD. Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J 2010; 185:23–27.
• Dinarello CA. Interleukin-1 and its biologically related cytokines. Adv Immunol 1989; 44:153-205.
• Gruys E, Obwolo MJ, Toussaint MJM. Diagnostic significance of major acute phase proteins in veterinary clinical chemistry: a review. Vet Bull 1994; 64:1009-10018
• Niewold TA, Tousaint MJM, Gruys E. Monitoring health by acute phase proteins, Fourth Europan Colloquim on acute phase proteins, Segova, Spain 2003; ss 57-67
• Nukina H, Sudo N, Aiba Y, et al. Restraint stress elevates the plasma interleukin-6 levels in germ-free mice. Journal of Neuroimmunology 2001; 115:46-52.
• Chan JPW, Chu CC, Fung HP, et al. Serum haptoglobin concentration in cattle. J Vet Med Sci 2004; 66:43-46.
• Eckersall PD. Recent advances and future prospects for the use of acute phase proteins as marker of disease in animals. Revue Med Vet 2000; 151:577-584.
• Çitil M. Puerperal infeksiyonlu ve abomasum deplasmanlı ineklerde Serum Amiloid A ve haptoglobin düzeyleri. Kafkas Üniv Vet Fak Derg 2003;9(2):147-51.
• Eckersall PD, Safi S, Weber A, et al. The acute phase protein response of haptoglobin serum amyloid A and α1-acid glycoprotein in dairy cows with mastitis, The 4th European Comparative Clinical Pathology Meeting, Verona, İtalya 1999.
• Heegaard PMH, Godson DL, Toussaint MJM, et al. The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with respiratory syncytial virus Vet immunol immunopathol 2000; 77:151-159.
• Güzelbektaş H, Sen I, Ok M, et al. Serum amyloid a and haptoglobin concentrations and liver fat percentage in lactacting dairy cows with abomasal displacement. J Vet Int Med. 2010; 24:213-219.
• Humblet MF, Guyot H, Boudry B, et al. Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period. Vet Clin Pathol 2006; 35:188-93.
• Chan JP, Chang CC, Hsu WL, et al. Association of increased serum acute-phase protein concentrations with reproductive performance in dairy cows with postpartum metritis. Vet Clin Pathol 2010; 39:72-78.
• Skinner JG, Brown RA, Roberts L. Bovine haptoglobin response in clinically defined field conditions. Vet Rec 1991; 16:147-9.
• Nazifi, S., Ansari-Lari, M., Asadi-Fardaqi, J., et al. The use of receiver operating characteristic (ROC) analysis to assess the diagnostic value of serum amyloid A, haptoglobin and fibrinogen in traumatic reticuloperitonitis in cattle. Vet J 2009; 182:315-9.
• Pineiro M, Alava MA, Lampreave F, Acute phase proteins in different species: a review. Fourth Europan Colloquim on acute phase proteins. Segova, Spain 2003; ss 77-82
• Deignan T, Alwan A, Kelly J, et al. Serum haptoglobin: an indicator of experimentally- induced salmonella infection in calves, Res Vet Sci 2000; 69:153-158.
• Humblet MF, Coghe J, Lekeux P, et al. Acute phase ptotein assessment for an early selevtion treatments in growing calves suffering from bronchopneumonia under field conditions. Res Vet Sci 2004; 77:41-47.
• Grönlund U, Waller KP, Sandgren CH. Are milk haptoglobin and serum amyloid A indicators of sub-clinical mastitis. Fourth Europan Colloquim on acute phase proteins, Segova, Spain 2003.
• Jacopsen S, Niewold TA, Kornalijnslijper E, et al. The kinetics of serum amyloid A accumulation in milk from cows with experimentally induced E. coli mastitis, Fourth Europan Colloquim on acute phase proteins, Segova, İspanya 2003.
• Lomborg SR, Nielsen LR, Heegaard PMH et al. Acute phase proteins in cattle after exposure to complex stres. Vet Res Commun 2008; 32:575-582.
• Alsemgeest SPM, Lamboy IE, Wierenga HK, et al. Influence of physical stress on the plasma concentration of serum amyloid –a and haptoglobin in calves. Vet Q 1995; 17:9- 12.
• Horadagoda NU, Knox KMG, Gibbs HA, et al. Acute phase proteins in cattle: discrimination between acute and chronic inflamation. Vet Rec 1999; 144:437-441.
• Glass EJ, Craigmile SC, Springbett A, et al. The protozoan parasite, Theleria annulata, induces a distinct acute phase protein response in cattle that is associated with pathology. Int J Parasitol 2003; 33:1409- 1418.
• Coskun A, Sen I, The importance in clinical diagnosis of acute phase protein in calves that experimentally lipopolisaccharide ınduced endotoxemia. XXV. World Buiatri Congres, Budapest, Hungary 2008; ss 231.
• Orro T, Pohjanvirta T, Rikula U et al. Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus. Comp Immunol Microbiol Infect Dis. 2009; 34;23- 29.
• Angen O, Thomsen J, Larsen LE, et al. R e s p i r a t o r y d i s e a s e i n c a l v e s : microbiological investigations on trans- tracheally aspirated bronchoalveolar fluid and acute phase protein response Vet Microbiol. 2009; 28:165-71.
• Lee WC, Hsiao HC, Wu YL,et al. Serum C- reaktive protein in dairy herds. Can J Vet Res 2003; 67:102-107.
• Schroedl W, Jaekel L, Krueger M. Creaktive protein and antibacterial activity in blood plasma of colostrum-fed calves and the effect of lactulose Journal Dairy Science 2003; 86: 3313-3320
• Ok M, Aslan V. Retikuloperitonitis Travmatikalı sığırların teşhis ve prognozun da kan proteinleri ve gluteraldehit testinin öne- mi, Vet Bil Derg 1994; 10:90-95.
• Ganheim C, Hoglund J, Waller KP. Acute phase protein in response Dictyocaulus viviparus infection in calves. Acta Vet Scand 2004; 45:79-86.
• Schroıedl W, Fuerll B, Reinhold P, et al. A novel acute phase marker in cattle: Lipopolysaccharide binding protein (LBP) J Endotoxin Res 2001; 7:49-52.
• Pineiro M, Andres M, Iturralde M, et al. ITIH4 (Inter-alfa-trypsin inhibitor heavy chain 4) is a new acute phase protein ısolated from cattle during experimental infection. Infect Immun 2004; 72:3777-3782.