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HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR

Year 2017, Volume: 26 Issue: 3, 233 - 239, 01.12.2017

Abstract

Çalışmanın amacı, deneysel hipotiroidi (HT) geliştirilen
sıçanlarda uzamsal öğrenme ve bellek bozukluklarının
cinsiyet ile ilişkisini ortaya koymaktır. Hipotiroidi oluşturmada propiltiourasil (PTU) kullanılmıştır (0,2 mg/
kg, içme suları ile 21 gün). Öğrenme ve hafıza değişimlerini değerlendirmede Morris Su Tankı Testi kullanılmıştır. Test değerlendirmesi, anksiyete düzeyini ifade
eden tigmotaksis oranı, HT grubunun kontrolden daha
az anksiyete sergilediğini, Grup*Cinsiyet etkileşimi arasında ise önemli farklılığın olmadığını göstermiştir. Dişi
sıçanların yüzme hızları erkek sıçanlara göre daha yavaş bulunmuştur. Öğrenme performansı değerlendirmesinde platforma ulaşma süresi, yüzme mesafesi ve
platforma olan ortalama uzaklık değerlendirilmiştir.
Kaçış mesafesi ve yüzme mesafesi değerlendirildiğinde
hipotiroidi durumu platformu bulma süresini uzatmış,
yüzme mesafesini arttırmıştır. Ancak cinsiyet faktörü
hipotiroidideki bozulmaya etki etmemiştir. Yüzme hızından etkilenmeyen platforma olan ortalama uzaklık
değerlendirildiğinde dişilerde öğrenme performansı
anlamlı (p<0,001) bir şekilde azalmıştır ve hipotiroidi
durumu bu azalmaya etki etmemiştir. Ayrıca tek başına
hipotiroidi durumu platforma olan ortalama uzaklığı
arttırmıştır. Post Hoc Tukey testine göre , hipotiroidili
grupların kontrol gruplarına göre hedef kadranda daha
az süre geçirdiği tespit edilmiştir (p<0,05). Ancak cinsiyet faktörü bu anlamlılığı etkilememiştir. Sonuç olarak
hipotiroidi oluşturduğumuz hayvanlarda öğrenme ve
hafıza performansının bozulduğu, hipotirodide görülen
bu bozukluğa cinsiyet farklılığının bir etkisi olmadığı
görülmüştür.

References

  • 1. Eichenbaum H. Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 2004; 44:109-120.
  • 2. Squire LR, Zola SM. Structure and function of declarative and nondeclarative memory systems. Proceedings of the National Academy of Sciences 1996; 93:13515-13522.
  • 3. Kesner RP, Hopkins RO. Mnemonic functions of the hippocampus: a comparison between animals and humans. Biological Psychology 2006; 73:3-18.
  • 4. Olton DS, Paras BC. Spatial memory and hippocampal function. Neuropsychologia 1979; 17:669-682.
  • 5. Arthur C.Guyton JEH. Textbook of Medical Physiology (eleventh edition ed). 2016; pp 934- 939 .
  • 6. Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone action. Trends in Endocrinology & Metabolism 2005; 16:429-435.
  • 7. Davis PJ, Shih A, Lin H-Y, Martino LJ, Davis FB. Thyroxine promotes association of mitogenactivated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR. Journal of Biological Chemistry 2000; 275:38032-38039.
  • 8. Warren SG, Juraska JM. Spatial and nonspatial learning across the rat estrous cycle. Behavioral Neuroscience 1997; 111:259.
  • 9. Berry B, McMahan R, Gallagher M. Spatial learning and memory at defined points of the estrous cycle: effects on performance of a hippocampaldependent task. Behavioral Neuroscience 1997; 111:267.
  • 10. Tong H, Chen G-H, Liu R-Y, Zhou J-N. Age-related learning and memory impairments in adult-onset hypothyroidism in Kunming mice. Physiology & Behavior 2007; 91:290-298.
  • 11. Figueiredo B, Almazan G, Ma Y, Tetzlaff W, Miller F, Cuello A. Gene expression in the developing cerebellum during perinatal hypo-and hyperthyroidism. Molecular Brain Research 1993; 17:258-268.
  • 12. Patel AJ, Hayashi M, Hunt A. Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life. Brain Research 1987; 422:182- 185.
  • 13. Ji C, Shao J, Zhao Z, Huang X, Mao S. Expression of androgen receptor gene in cerebral cortex and hippocampus of rats with perinatal hypothyroidism. Zhejiang da xue xue bao Yi xue ban= Journal of Zhejiang University Medical Sciences 2005; 34:293-297.
  • 14. Morris R, Schenk F, Tweedie F, Jarrard L. Ibotenate lesions of hippocampus and/or subiculum: dissociating components of allocentric spatial learning. European Journal of Neuroscience 1990; 2:1016-1028.
  • 15. Epp JR, Chow C, Galea LA. Hippocampus-dependent learning influences hippocampal neurogenesis. Frontiers In Neuroscience 2013; 7.
  • 16. Abd Allah E, Gomaa A, Sayed M. The effect of omega -3 on cognition in hypothyroid adult male rats. Acta Physiologica Hungarica 2014; 101:362-376.

Gender-Dependent Differences on Spatial Learning Performance in Hypothyroid Rats

Year 2017, Volume: 26 Issue: 3, 233 - 239, 01.12.2017

Abstract

The aim of the study was to investigate the effects of
experimental hypothyroidism (HT) on spatial learning
and memory disorders to establish relationship with
gender. Propylthiouracil (PTU) was used to induce HT
(0.2 mg / kg, 21 days with drinking water). Morris
Water Tank test (MWTT) was used to evaluate learning
and memory changes. When the anxiety level was
expressed as the rate of tigmotaxis in the MWVT, it was
found that the HT group was less anxious than the
control group and there was no significant difference
between the Group*Sex interaction. The swimming
speed (SS) of female groups was found to be slower
than the male groups. In evaluating the learning
performance, the mean distance to platform (MdtoP),
distance movement (DM) and escape latency (EL) was
evaluated. During EL and DM assessment, the HT state
prolonged the time to find the platform and increased
swimming distance. However, the gender factor did not
affect the deterioration of the HT state. Evaluating the
MdtoP, which is not affected by SS, the learning
performance in female was significantly reduced
(p<0,001) and the HT state did not affect this decrease.
In addition, hypothyroid status alone increased the
mean distance to platform. According to the Post Hoc
Tukey test, HT groups were realized that it spent less
time than the control groups in target quadrant
(p<0,05). However, the gender factor did not affect this
significance. As a result, we found that the animals with
hypothyroidism had poor learning and memory
performance, and gender difference did not affect this
deterioration in hypothyroidism.

References

  • 1. Eichenbaum H. Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 2004; 44:109-120.
  • 2. Squire LR, Zola SM. Structure and function of declarative and nondeclarative memory systems. Proceedings of the National Academy of Sciences 1996; 93:13515-13522.
  • 3. Kesner RP, Hopkins RO. Mnemonic functions of the hippocampus: a comparison between animals and humans. Biological Psychology 2006; 73:3-18.
  • 4. Olton DS, Paras BC. Spatial memory and hippocampal function. Neuropsychologia 1979; 17:669-682.
  • 5. Arthur C.Guyton JEH. Textbook of Medical Physiology (eleventh edition ed). 2016; pp 934- 939 .
  • 6. Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone action. Trends in Endocrinology & Metabolism 2005; 16:429-435.
  • 7. Davis PJ, Shih A, Lin H-Y, Martino LJ, Davis FB. Thyroxine promotes association of mitogenactivated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR. Journal of Biological Chemistry 2000; 275:38032-38039.
  • 8. Warren SG, Juraska JM. Spatial and nonspatial learning across the rat estrous cycle. Behavioral Neuroscience 1997; 111:259.
  • 9. Berry B, McMahan R, Gallagher M. Spatial learning and memory at defined points of the estrous cycle: effects on performance of a hippocampaldependent task. Behavioral Neuroscience 1997; 111:267.
  • 10. Tong H, Chen G-H, Liu R-Y, Zhou J-N. Age-related learning and memory impairments in adult-onset hypothyroidism in Kunming mice. Physiology & Behavior 2007; 91:290-298.
  • 11. Figueiredo B, Almazan G, Ma Y, Tetzlaff W, Miller F, Cuello A. Gene expression in the developing cerebellum during perinatal hypo-and hyperthyroidism. Molecular Brain Research 1993; 17:258-268.
  • 12. Patel AJ, Hayashi M, Hunt A. Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life. Brain Research 1987; 422:182- 185.
  • 13. Ji C, Shao J, Zhao Z, Huang X, Mao S. Expression of androgen receptor gene in cerebral cortex and hippocampus of rats with perinatal hypothyroidism. Zhejiang da xue xue bao Yi xue ban= Journal of Zhejiang University Medical Sciences 2005; 34:293-297.
  • 14. Morris R, Schenk F, Tweedie F, Jarrard L. Ibotenate lesions of hippocampus and/or subiculum: dissociating components of allocentric spatial learning. European Journal of Neuroscience 1990; 2:1016-1028.
  • 15. Epp JR, Chow C, Galea LA. Hippocampus-dependent learning influences hippocampal neurogenesis. Frontiers In Neuroscience 2013; 7.
  • 16. Abd Allah E, Gomaa A, Sayed M. The effect of omega -3 on cognition in hypothyroid adult male rats. Acta Physiologica Hungarica 2014; 101:362-376.
There are 16 citations in total.

Details

Other ID JA65ZC99AC
Journal Section Research Article
Authors

Ercan Babur

Burak Tan This is me

Nesrin Yıldız This is me

Melek Batakçı This is me

Cem Süer This is me

Nurcan Dursun This is me

Publication Date December 1, 2017
Submission Date December 1, 2017
Published in Issue Year 2017 Volume: 26 Issue: 3

Cite

APA Babur, E., Tan, B., Yıldız, N., Batakçı, M., et al. (2017). HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR. Sağlık Bilimleri Dergisi, 26(3), 233-239.
AMA Babur E, Tan B, Yıldız N, Batakçı M, Süer C, Dursun N. HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR. JHS. December 2017;26(3):233-239.
Chicago Babur, Ercan, Burak Tan, Nesrin Yıldız, Melek Batakçı, Cem Süer, and Nurcan Dursun. “HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR”. Sağlık Bilimleri Dergisi 26, no. 3 (December 2017): 233-39.
EndNote Babur E, Tan B, Yıldız N, Batakçı M, Süer C, Dursun N (December 1, 2017) HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR. Sağlık Bilimleri Dergisi 26 3 233–239.
IEEE E. Babur, B. Tan, N. Yıldız, M. Batakçı, C. Süer, and N. Dursun, “HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR”, JHS, vol. 26, no. 3, pp. 233–239, 2017.
ISNAD Babur, Ercan et al. “HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR”. Sağlık Bilimleri Dergisi 26/3 (December 2017), 233-239.
JAMA Babur E, Tan B, Yıldız N, Batakçı M, Süer C, Dursun N. HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR. JHS. 2017;26:233–239.
MLA Babur, Ercan et al. “HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR”. Sağlık Bilimleri Dergisi, vol. 26, no. 3, 2017, pp. 233-9.
Vancouver Babur E, Tan B, Yıldız N, Batakçı M, Süer C, Dursun N. HİPOTİROİDİLİ SIÇANLARDA UZAMSAL ÖĞRENME PERFORMANSINDA CİNSİYET BAĞIMLI FARKLILIKLAR. JHS. 2017;26(3):233-9.