ANTRENMANLI ERKEK BİREYLERDE ANAEROBİK EŞİKTE YAPILAN EGZERSİZİN NESFATİN-1 HORMONU ÜZERİNE OLANETKİLERİNİN BELİRLENMESİ

Year 2018, Volume: 27 Issue: 2, 132 - 136, 01.07.2018

Çağrı Özdenk

Abstract

Anaerobik eşikte yapılan egzersizin nesfatin-1 seviyeleri
üzerine etkileri antrenmanlı erkek deneklerde araştırıldı. Toplam 30 erkek denek sabah saatlerinde 30 dakikalık aerobik koşma egzersizi gerçekleştirdi. Venöz kan
örnekleri istirahat ve test sonunda alındı. Nesfatin-1
seviyesi ELISA metodu ile belirlendi. Nesfatin-1 değerleri istirahatte 102.8±5.1 ng/ml olarak tespit edilmiş ve
test sonunda 109.6±6.2 ng/ml seviyesine yükselmiştir.
Fakat bu yükselme istatistiksel olarak belirgin değildir
(P=0.3). Nesfatin-1 seviyesi vücut ağırlığına standardize
edildiğinde 1.695±0.09 ng/ml/kg olarak bulunmuştur.
Vücut ağırlığının nesfatin-1 seviyelerine oranı ile egzersiz sırasında nesfatin-1 seviyesi değişimi arasında bir
korelasyon bulundu: R=0.50858 (p=0.004). Bu çalışmada nesfatin-1’in egzersiz kaynaklı bir hormon olmadığını fakat bireyden bireye artma veya azalma değişiklik
gösterdiğini elde ettik. Bu nedenle değişik fitnes seviyesindeki deneklerde ileri çalışmalara ihtiyaç duyulmaktadır.

Keywords

Egzersiz, Anaerobik eşik, Nesfatin1, Enerji, Fitnes

Determination of Effects of Exercise at Anaerobic Threshold on Nesfatin-1 Hormone in Trained Male Subjects

Abstract

The effects of exercise at the anaerobic threshold on
nesfatin-1 levels have been investigated in trained male
subjects. A total of 30 males performed an aerobic running exercise for 30 min in mornings. Venous blood
samples were taken at rest and at the end of the test.
ELISA method was used to analyse nesfatin-1 levels.
Nesfatin-1 levels were found to be 102.8±5.1 ng/ml at
rest and it increased to 109.6±6.2 ng/ml at the end of
the test. However, this increase was not statistically
significant (P=0.3). The nesfatin-1 level was found to be
1.695±0.09 ng/ml/kg when standardised to body
weight. There was a correlation between body weight
to nesfatin-1 levels and change of nesfatin-1 levels during exercise: R=0.50858 (p=0.004). We showed that
nesfatin-1 is not exercise induced hormone but it may
vary among the subjects either increasing or decreasing. Thus further studies should be performed in subjects with carying fitness status.

Keywords

Exercise, Anaerobic threshold, Nesfatin-1, Energy, Fitness

References

• 1. Kujala UM. Evidence on the effects of exercise therapy in the treatment of chronic disease. Br J Sports Med 2009; 43:550–555.
• 2. Smart N, Marwick TH. Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity. Am J Med 2004; 116:693–706.
• 3. Warburton DER., Nicol CW, Bredin SSD. Health benefits of physical activity: the evidence. Canadian Medical Association Journal 2006; 174:801–809.
• 4. Hazell TJ, Islam H, Townsend LK, et al. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite 2016; 98:80-88.
• 5. Hopkins M, King NA, Blundell JE. Acute and longterm effects of exercise on appetite control: is there any benefit for weight control? Curr Opin Clin Nutr Metab Care 2010; 13:635-640.
• 6. Ozcelik O, Celik H, Ayar A, et al. Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females. Neuroendocrinology Letters 2004; 25:381-385.
• 7. Oh-I S, Shimizu H, Satoh T, et al. Identification of nesfatin- 1 as a satiety molecule in the hypothalamus. Nature 2006; 443:709-712.
• 8. Ramanjaneya M, Chen J, Brown JE, et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 2010; 151:3169-3180.
• 9. Stengel A, Goebel M, Yakubov I, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009; 150:232-238.
• 10. Zhang AQ, Li XL, Jiang CY, et al. Expression of nesfatin-1/NUCB2 in rodent digestive system. World J Gastroenterol 2010; 16:1735-1741.
• 11. Wernecke K, Lamprecht I, Jöhren O, et al. Nesfatin1 increases energy expenditure and reduces food intake in rats. Obesity (Silver Spring) 2014; 22:1662-1668.
• 12. Könczöl K, Pinter O, Ferenczi S, et al. Nesfatin-1 exerts long-term effect on food intake and body temperature. Int J Obes (Lond) 2012; 36:1514- 1521.
• 13. Maejima Y, Sedbazar U, Suyama S, et al. Nesfatin-1- regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptinindependent melanocortin pathway. Cell Metab 2009 ;10:355-365.
• 14. Shimizu H, Inoue K, Mori M. The leptin-dependent and-independent melanocortin signaling system: Regulation of feeding and energy expenditure. J Endocrinol 2007; 193: 1-9.
• 15. Algul S, Ozcelik O. Determination of the effects of acute aerobic exercise on nesfatin-1 levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 2016; 30:5- 8.
• 16. Yosten GL, Samson WK. Cardiovascular and antidipsogenic effects of nesfatin-1. Curr Pharm Des 2013;19:6973-6975
• 17. Algul S, Ozcelik O. Evaluating the levels of nesfatin1 and ghrelin hormones in patients with moderate and severe major depressive disorders. Psychiatry investig 2018; 15:214-218.
• 18. Palasz A, Krzystanek M, Worthington J, et al. Nesfatin-1 a unique regulatory neuropeptide of the brain. Neuropeptides 2012; 46:105-112.
• 19. Algul S, Ozcelik O. A new promising pepdide for obesity treatment: Nesfatin-1. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 2012; 26:143-148.
• 20. Chen X, Dong J, Jiang ZY. Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake. Regul Pept 2012; 177:21-26.
• 21. Shimizu H, Oh-I S, Okada S, et al. Nesfatin-1: an overview and future clinical application. Endocr J 2009; 56:537-543.
• 22. Wasserman, K, Hansen JE, Sue DY, et al. Principles of exercise testing and interpretation: including pathophysiology and clinical applications. 5th ed., Lippincott Williams & Wilkins, New York, NY, USA 2012.
• 23. Ozcelik, O, Ozkan Y, Algul, S, et al. Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity
• 24. Kaya H, Ozcelik O. Tıp öğrencilerinde bir yılda vücut kompozisyonlarında meydana gelen değişimlerin belirlenmesi. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 2005; 10:164-168.
• 25. American College of Sports Medicine (ACSM). Guidelines for Exercise Testing and Prescription (9th ed.). Baltimore, MD: Lippincott, Williams and Wilkins, 2014.
• 26. Foo KS, Brismar H, Broberger C. Distribution a neuropeptide coexistence of nocleobindin-2 mRNA/ nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008; 156:563-579.
• 27. Algül S. Psychiatric disorders and nesfatin-1 psikiyatrik hastalıklar ve nesfatin-1. Journal of Human Sciences 2015; 12:1397-1407.
• 28. Xu YY, Ge JF, Oin G, et al. Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/ nesfatin-1 in rats. Neuropeptides 2015; 54:47-53.
• 29. Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol 2010; 110:863-868.
• 30. Yazıcı AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab/Turk Fiz Tıp Rehab Derg 2015; 61:234-240.
• 31. Mohebbi H, Nourshahi M, Ghasemikaram M, et al. Effects of exercise at individual anaerobic threshold and maximal fat oxidation intensities on plasma levels of nesfatin-1 and metabolic health biomarkers. J Physiol Biochem 2015; 71:79-88.
• 32. Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport 2017; 34:339-344.
• 33. Martins C, Stensvold D, Finlayson G, et al. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Med Sci Sports Exerc 2015; 47:40-48.
• 34. Schubert MM, Sabapathy S, Leveritt M, et al. Acute exercise and hormones related to appetite regulation: a meta-analysis. Sports Med 2014; 44:387-403.
• 35. Ahmadizad S, Avansar AS, Ebrahim K, et al. The effects of short-term high-intensity interval training vs. moderate intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig 2015; 21:165 -173.
• 36. Chaolu H, Asakawa A, Ushikai M, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2:369-373.
• 37. Hofmann T, Ahnis A, Elbelt U, et al. NUCB2/nesfatin -1 is associated with elevated levels of anxiety in anorexia nervosa. PLoS One 2015; 10:1-15.
• 38. Algul S, Ozkan Y, Ozcelik O. Serum nesfatin-1 levels in patients with different glucose tolerance levels. Physiol Res 2016; 65:979-985.