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Piridin ve ellagik asit uygulanan farelerde oksidatif stres indeksinin araştırılması

Year 2015, Volume: 31 Issue: 3, 148 - 151, 01.09.2015

İnan Kaya Haci Ahmet Deveci Mahmut Karapehlivan Abdulsamed Kükürt

Abstract

Amaç: Bu çalışmada, piridin intoksikasyonunda paraoksonaz (PON1) aktivitesi, oksidatif stres indeksi (OSİ), total antioksidan (TAS) ve total oksidan (TOS) seviyeleri üzerine ellagik asitin etkisinin araştırılması amaçlandı. Gereç ve Yöntem: Çalışmada 28 adet erkek Swiss albino fare 4 eşit gruba ayrıldı. Grup I’e (Kontrol grup, n:7, 0.9% NaCl, IP, SID, 7 gün), Grup II’e piridin (n:7, 100 mg/kg, IP, SID, 7 gün), Grup III’e ellagik asit (n:7, 10 mg/kg, SC, SID, 7 gün) ve Grup IV’e ise piridin (n:7, 100 mg/kg, IP, SID, 7 gün) ile ellagik asit (n:7, 10 mg/kg, SC, SID, 7 gün) verildi. Deneysel uygulamaların sonunda serum PON1 aktivitesi, OSİ, TAS ve TOS seviyeleri spektrofotometrik olarak analiz edildi. Bulgular: Piridin verilen farelerde kontrol grubuna göre PON1 aktivitesi ve TAS seviyeleri azalırken, OSİ ve TOS seviyelerinin önemli oranda arttığı saptandı. Öneri: Ellagik asit, piridin tarafından oluşturulan oksidatif strese karşı koruyucu etki gösterebilir.

Keywords

Fare piridin paraoksonaz oksidatif stres ellagik asit

Investigation of oxidative stress index in pyridine and ellagic acid treated mice

Year 2015, Volume: 31 Issue: 3, 148 - 151, 01.09.2015

İnan Kaya Haci Ahmet Deveci Mahmut Karapehlivan Abdulsamed Kükürt

Abstract

Aim: In the present study, effect of ellagic acid on levels of paraoxonase (PON1), oxidative stress index (OSI), total antioxidant (TAS) and total oxidant (TOS) in pyridine intoxication was investigated. Material and Methods: In the study, 28 male Swiss albino mice were divided into 4 equal groups as following. Control I (Control group, n:7, 0.9% NaCl, IP, SID, 7 days), Group II was applied with pyridine (n:7, 100 mg/kg, IP, SID, 7 days), Group III was applied with ellagic acid (n:7, 10 mg/kg, SC, SID, 7 days) and Group IV was treated with pyridine (100 mg/kg, IP, SID, 7 days) plus ellagic acid (10 mg/kg, SC, SID, 7 days). Serum PON1 activity, OSI, TAS and TOS levels were determined by spectrophotometric methods at the end of the experiment.Results: OSI and TOS levels significantly increased, whereas serum PON1 activity and TAS levels reduced in pyridine treatment group (Group II) when compared to control group. Conclusion: Ellagic acid may show the protective effects against pyridine-induced oxidative stress.

Keywords

Mice pyridine paraoxonase oxidative stress ellagic acid

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Details

Other ID JA46MA46DP
Journal Section Research
Authors

İnan Kaya This is me

Haci Ahmet Deveci This is me

Mahmut Karapehlivan This is me

Abdulsamed Kükürt This is me

Publication Date September 1, 2015
Published in Issue Year 2015 Volume: 31 Issue: 3

Cite

APA Kaya, İ., Deveci, H. A., Karapehlivan, M., Kükürt, A. (2015). Investigation of oxidative stress index in pyridine and ellagic acid treated mice. Eurasian Journal of Veterinary Sciences, 31(3), 148-151.
AMA Kaya İ, Deveci HA, Karapehlivan M, Kükürt A. Investigation of oxidative stress index in pyridine and ellagic acid treated mice. Eurasian J Vet Sci. September 2015;31(3):148-151.
Chicago Kaya, İnan, Haci Ahmet Deveci, Mahmut Karapehlivan, and Abdulsamed Kükürt. “Investigation of Oxidative Stress Index in Pyridine and Ellagic Acid Treated Mice”. Eurasian Journal of Veterinary Sciences 31, no. 3 (September 2015): 148-51.
EndNote Kaya İ, Deveci HA, Karapehlivan M, Kükürt A (September 1, 2015) Investigation of oxidative stress index in pyridine and ellagic acid treated mice. Eurasian Journal of Veterinary Sciences 31 3 148–151.
IEEE İ. Kaya, H. A. Deveci, M. Karapehlivan, and A. Kükürt, “Investigation of oxidative stress index in pyridine and ellagic acid treated mice”, Eurasian J Vet Sci, vol. 31, no. 3, pp. 148–151, 2015.
ISNAD Kaya, İnan et al. “Investigation of Oxidative Stress Index in Pyridine and Ellagic Acid Treated Mice”. Eurasian Journal of Veterinary Sciences 31/3 (September 2015), 148-151.
JAMA Kaya İ, Deveci HA, Karapehlivan M, Kükürt A. Investigation of oxidative stress index in pyridine and ellagic acid treated mice. Eurasian J Vet Sci. 2015;31:148–151.
MLA Kaya, İnan et al. “Investigation of Oxidative Stress Index in Pyridine and Ellagic Acid Treated Mice”. Eurasian Journal of Veterinary Sciences, vol. 31, no. 3, 2015, pp. 148-51.
Vancouver Kaya İ, Deveci HA, Karapehlivan M, Kükürt A. Investigation of oxidative stress index in pyridine and ellagic acid treated mice. Eurasian J Vet Sci. 2015;31(3):148-51.