Cerebellar cortical abiotrophy in a Samoyed dog

Year 2014, Volume: 30 Issue: 1, 44 - 47, 01.03.2014

Mehdi Saberi Reza Kheirandish Shahrzad Azizi Elham Mohebbi

Abstract

Cerebellar abiotrophies have a non-sex-linked, autosomal,
recessively inherited basis in anumber of animal species,
and lesions typically reflect progressive loss of Purkinje cells.
In this report, ataxia was observed in a one-week-old male
Samoyed puppy with no history of trauma or any other illness.
Physical examination revealed uncoordinated movements,
mild trunkal ataxia and intensive head tremors, so
the dog had trouble eating, evacuating and difficulties in
standing and walking without falling. The complete cell
count, cerebrospinal fluid analysis and cerebral radiographs
were normal. Treatment with diazepam, vitamin B1 and glucocorticoids
had no effect on clinical signs and the dog died
after a month. According to clinical signs and histopathological
features, cerebellar cortical abiotrophy was diagnosed.
This is the first report of a cerebellar cortical abiotrophy in a
Samoyed puppy.

Keywords

Samoyed, cerebellar abiotrophy, granular cells, Purkinje cells

Bir Samoyed köpekte serebellar kortikal abiotrofi

Abstract

Serebellar abiotrofi birçok hayvan türünde cinsiyetten ba-
ğımsız, otozomal, kalıtsal nitelikte tipik olarak Purkinje hücrelerinin
progresif kaybıyla karakterize bir durumdur. Mevcut
vakada travma veya başka hastalık hikayesi olmayan
ataksi gözlenen bir haftalık Samoyed ırkı bulunmaktadır. Fiziksel
muayenede kontrolsüz hareketler, gövdede ılımlı ataksi
ve başta şiddetli titremeler gözlendi. Ayrıca köpek yerken
sıkıntılı, otururken ve yürürken düşmeden sıkıntılı gözlendi.
Hastada tam kan, serebrospinal sıvı analizi ve serebral radiyografi
normal gözlendi. Tedavide uygulanan diazepam, vitamin
B1
ile glukokortikoidler klinik belirtiler üzerine etkili olmadı
ve bir ay sonra köpek öldü. Klinik ve histopatolojik belirtilere
göre serebellar kortikal abiotrofi olgusu tanımlandı.
Mevcut vaka Samoyed ırkı köpekte tanımlanan ilk serebellar
kortikal abiotrofi özelliğinin taşımaktadır.

Keywords

Samoyed, serebellar abiotrofi, granular hücreler, Purkinje hücreleri

References

• Berry ML, Blas-Machado U, 2003. Cerebellar abiotrophy in a miniature schnauzer. Can Vet J 44, 657-659.
• Bildfell RJ, Mitchell SK, de Lahunta A, 1995. Cerebellar cor- tical degeneration in a Labrador retriever. Can Vet J, 36, 570-572.
• Chieffo C, Stalis IH, Van Winkle TJ, Haskins ME, Patterson DF, 1994. Cerebellar Purkinje's cell degeneration and coat co- lour dilution in a family of Rhodesian ridge back dog. J Vet Intern Med, 8, 112-116.
• Cordy DR, Snelbaker HA, 1952. Cerebellar hypoplasia and de- generation in a family of airedale dogs. J Neuropathol exp Neurol, 11, 324-328.
• de Lahunta A, Averill DR Jr, 1976. Hereditary cerebellar cor- tical and extrapyramidal nuclear abiotrophy in Kerry Blue Terriers. J Am Vet Med Assoc, 1119-1124.
• de Lahunta A, Fenner WR, Indrieri RJ, Mellick PW, Gardner S, Bell JS, 1980. Hereditary cerebellar cortical abiotrophy in the Gordon Setter.J Am Vet Med Assoc, 177, 538-541.
• de Lahunta A, 1990. Abiotrophy in domestic animals. Can J Vet Res, 54, 65-76.
• Gill JM, Hewland M, 1980. Cerebellar degeneration in a bor- der collie. NZ Vet J, 28, 170.
• Hartley WJ, Barker JSF, Wanner RA, Farrow BRH, 1978. In- herited cerebellar degeneration in the rough coated Collie. Aust Vet Pract, 8, 79-85.
• Mouser P, Le´Vy M, Sojka JE, Ramos-Vara JA, 2009. Cerebel- lar Abiotrophy in an Alpaca (Lama pacos). Vet Pathol, 46, 1133-1137.
• Palmer AC, Payne JE, Wallace ME, 1973. Hereditary quadrip- legia and amblyopia in the Irish Setter.J Small Anim Pract, 14, 343-352.
• Sandefeldt E, Cummings JF, De Lahunta A, Bjorck G, Krook L. 1973. Hereditary neuronal abiotrophy in the Swedish Lap- land dog. Cornell Vet, 63, 1-71.
• Sandy JR, Slocombe RF, Mitten RW, Jedwab D, 2002. Cerebel- lar abiotrophy in a family of Border Collie dogs. Vet Pathol, 39, 736-738.
• Summers BA, Cummings JF, De Lahunta A, 1995. Degenera- tive diseases of the central nervous system.Veterinary Ne- uropathology. 1st edition, St. Louis: Mosby-Year Book, pp: 300-305.
• Tatalick LM, Marks SL, Baszler TV, 1993. Cerebellar abiot- rophy characterized by granular cell loss in a Brittany. Vet Pathol, 30, 385-388.
• Thomas, JB, Robertson D, 1989. Hereditary cerebellar abiot- rophy in Australian kelpie dogs. Aust Vet J, 66, 301-302.
• Tipold A, Fatzer R, Jaggy A, Moore P, Vandevelede M, 2000. Presumed immune-mediated cerebellar granuloprival de- generation in the Coton de Tulear breed. J Neuroimmunol, 110, 130-133.
• vanTongern SE, van Vonderen IK, van Nes JJ, Van denInght TS, 2000. Cerebellar cortical abiotrophy in two Portuguese Po- denco littermates. Vet Q, 22, 172-174.
• Yasuba M, Okimoto K, Iida M, Itakura C, 1988. Cerebellar cor- tical degeneration in Beagle dogs. Vet Pathol, 25, 315-7.