Cerebellar cortical abiotrophy in a Samoyed dog

Yıl 2014, Cilt: 30 Sayı: 1, 44 - 47, 01.03.2014

Mehdi Saberi Reza Kheirandish Shahrzad Azizi Elham Mohebbi

Öz

Cerebellar abiotrophies have a non-sex-linked, autosomal,
recessively inherited basis in anumber of animal species,
and lesions typically reflect progressive loss of Purkinje cells.
In this report, ataxia was observed in a one-week-old male
Samoyed puppy with no history of trauma or any other illness.
Physical examination revealed uncoordinated movements,
mild trunkal ataxia and intensive head tremors, so
the dog had trouble eating, evacuating and difficulties in
standing and walking without falling. The complete cell
count, cerebrospinal fluid analysis and cerebral radiographs
were normal. Treatment with diazepam, vitamin B1 and glucocorticoids
had no effect on clinical signs and the dog died
after a month. According to clinical signs and histopathological
features, cerebellar cortical abiotrophy was diagnosed.
This is the first report of a cerebellar cortical abiotrophy in a
Samoyed puppy.

Anahtar Kelimeler

Samoyed, cerebellar abiotrophy, granular cells, Purkinje cells

Bir Samoyed köpekte serebellar kortikal abiotrofi

Öz

Serebellar abiotrofi birçok hayvan türünde cinsiyetten ba-
ğımsız, otozomal, kalıtsal nitelikte tipik olarak Purkinje hücrelerinin
progresif kaybıyla karakterize bir durumdur. Mevcut
vakada travma veya başka hastalık hikayesi olmayan
ataksi gözlenen bir haftalık Samoyed ırkı bulunmaktadır. Fiziksel
muayenede kontrolsüz hareketler, gövdede ılımlı ataksi
ve başta şiddetli titremeler gözlendi. Ayrıca köpek yerken
sıkıntılı, otururken ve yürürken düşmeden sıkıntılı gözlendi.
Hastada tam kan, serebrospinal sıvı analizi ve serebral radiyografi
normal gözlendi. Tedavide uygulanan diazepam, vitamin
B1
ile glukokortikoidler klinik belirtiler üzerine etkili olmadı
ve bir ay sonra köpek öldü. Klinik ve histopatolojik belirtilere
göre serebellar kortikal abiotrofi olgusu tanımlandı.
Mevcut vaka Samoyed ırkı köpekte tanımlanan ilk serebellar
kortikal abiotrofi özelliğinin taşımaktadır.

Anahtar Kelimeler

Samoyed, serebellar abiotrofi, granular hücreler, Purkinje hücreleri

Kaynakça

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