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KLORAMFENİKOL ve METABOLİTLERİNİN MYELOTOKSİK ETKİLERİ

Year 1995, Volume: 11 Issue: 1, 95 - 97, 01.03.1995

Abstract

Kloramfenikol; gram negatif ve gram pozitif bakterileri, riketsiyalara ve psittakozis-lenfogranuloma grubu
mikroorganizmalara karşı etkili, geniş spektrumlu bir antibiyotiktir. En önemli istenmeyen özelliği pansitopeni ile
sonuçlanan kemik iliği depresyonudur. Bu durum bazı duyarlı kişilerde çok küçük dozlardaki kullanımlarda bile
meydana gelebilir. Türkiye'de ilacın sadece gıda olarak tüketilmeyen hayvanlarda kullanımına müsaade edilmiştir.
Ancak illegal kloramfenikol kullanımları mevcuttur. Kloramfenikol veya metabolitlerinin duyarlı kişilerde
apiastik anemi yapma eğilimi gözönünde bulundurularak, da olarak tüketilen hayvanlarda kullanımı yasaklanmıştır.
Bu makalede, kloramfenikol ve metabolitlerinin myelotoksik özellikleri incelenmiştir

MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES

Year 1995, Volume: 11 Issue: 1, 95 - 97, 01.03.1995

Abstract

Chloramphenicol has a broad spectrum of activity against both gram negative and gram positive
bacteria, richetsia, and psittacozis·lymphogranuloma group. The most important unwanted effect of chloramphenicol
is depression of the bone-marrow resulting in pancytopenia- an effect which may occur even with
very low doses in so me indivudials. Within the Turkey the drug is approved for use only in non-food producing
animals; it is illegal to use the drug in food animals.Prohibition of chloramphenicol for use in food animals is
based in the tendeney of chloramphenicoı or its metabolites to produce aplastic anemia in certain susceptible
people. ın this review, the myelotoxic effects of chloramphenicol and its metabolites are summarized.

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Details

Other ID JA73SP45TD
Journal Section Research
Authors

Ahmet Levent Baş This is me

Publication Date March 1, 1995
Published in Issue Year 1995 Volume: 11 Issue: 1

Cite

APA Baş, A. L. (1995). MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES. Eurasian Journal of Veterinary Sciences, 11(1), 95-97.
AMA Baş AL. MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES. Eurasian J Vet Sci. March 1995;11(1):95-97.
Chicago Baş, Ahmet Levent. “MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES”. Eurasian Journal of Veterinary Sciences 11, no. 1 (March 1995): 95-97.
EndNote Baş AL (March 1, 1995) MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES. Eurasian Journal of Veterinary Sciences 11 1 95–97.
IEEE A. L. Baş, “MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES”, Eurasian J Vet Sci, vol. 11, no. 1, pp. 95–97, 1995.
ISNAD Baş, Ahmet Levent. “MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES”. Eurasian Journal of Veterinary Sciences 11/1 (March 1995), 95-97.
JAMA Baş AL. MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES. Eurasian J Vet Sci. 1995;11:95–97.
MLA Baş, Ahmet Levent. “MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES”. Eurasian Journal of Veterinary Sciences, vol. 11, no. 1, 1995, pp. 95-97.
Vancouver Baş AL. MYELOTOXIC EFFECTS OF CHOLARAMPHENICOL AND ITS METABOLITES. Eurasian J Vet Sci. 1995;11(1):95-7.