Associations of glycated hemoglobin (HbA1c) level with central corneal and macular thickness in diabetic patients without macular edema

Year 2018, , 294 - 299, 04.10.2018

Kuddusi Teberik , Mehmet Tahir Eski , Murat Kaya

https://doi.org/10.18621/eurj.362263

Cited By: 1

Abstract

Objectives: To determine the correlation
between central corneal thickness (CCT) and central macular thickness (CMT),
and fasting plasma glucose levels and HbA1c levels before diabetic macular
edema (DME) in type 2 diabetes mellitus (DM) patients without diabetic
retinopathy.

Methods: Forty-four eyes of subjects diagnosed with type 2 DM,
and 45 healthy control subjects participated in this study. Detailed
ophthalmologic examination was performed with all participants. CMT was
measured in both groups by Spectral-domain optical coherence tomography. CCT
measurements were made with an Echoscan US-500 ultrasonic pachymeter. Blood
biochemical tests for glycated hemoglobin (HbA1c) and fasting plasma glucose
levels were run on all patients.

Results: The results of the study
showed that the mean CCT was significantly thicker in type 2 DM patients 563.84
± 33.25 μm
than in the controls 550.13 ± 28.41 μm (p = 0.039). The mean of CMT was 231.27 ±
37.74 μm
in the study group and 225.38 ± 38.33 μm in the control
group (p > 0.05). No relationship
was found between CCT and CMT and HbA1c level in the study and control groups.

Conclusions:
The mean CCT was significantly thicker in type 2 DM patients without diabetic
retinopathy than in the controls. The mean CMT is thicker in type 2 DM patients
without diabetic retinopathy patients than in the controls, but this difference
was not statistically significant. Optical coherence tomography can be a
perfect detector for early detection of DME. 

Keywords

Diabetic macular edema, HbA1c, fasting plasma glucose levels, central corneal thickness, central macular thickness

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