The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy

Year 2019, , 990 - 995, 04.11.2019

Mehmet Okka , Enver Mirza , Refik Oltulu , Selman Belviranlı Mehmet Kemal Gündüz

https://doi.org/10.18621/eurj.425740

Cited By: 1

Abstract

Objectives: To investigate the efficacy of the bleb needling
revision (BNR) procedure with the adjunctive use of 5-Fluorouracil (5-FU) in
encapsulated bleb after unsuccessful trabeculectomy.

Methods: We reviewed 16 eyes of 15 subjects who underwent BNR
procedure due to encapsulated
bleb after unsuccessful trabeculectomy. Demographic data, type of glaucoma,
intraocular pressure (IOP) values of pre-BNR, IOP values of post-BNR at first
day, first week and first month, follow up time and complications were recorded
from patients’ files, retrospectively.

Results: The mean follow up time was
53.1 ± 26.4 weeks. The average
time between previous unsuccessful trabeculectomy and BNR was 11.12 ± 8.79 weeks. The mean IOP
of pre-BNR was 26.0 ± 4.4 mmHg and
significantly decreased to 12.4 ± 5.0 mmHg post-BNR at the first day (p <
0.001). The mean IOP values of post-BNR at the first week was 13.3 ± 4.9 mmHg
and at the first month was 14.8 ± 4.8 mmHg. According to the mean IOP of
pre-BNR, the mean IOP values of
post-BNR at the first week and at the first month were significantly lower (p <
0.001 and p < 0.001, respectively). Seven (44%) eyes were achieved success and
eight (50%) eyes were achieved qualified success. One (6%) eye was
classified as the failure.

Conclusion: The bleb needling revision procedure with the
adjunctive use of 5-FU in encapsulated bleb after unsuccessful trabeculectomy
is a simple, useful and repeatable method to restore the dysfunctional bleb. 

Keywords

Bleb needling revision, 5-Fluorouracil, encapsulated bleb, trabeculectomy, filtration surgery

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