Intracytoplasmic sperm injection outcomes after anti-oxidant treatment in repeated implantation failure

Year 2019, , 868 - 872, 04.09.2019

Semih Tangal , Gamze Sinem Çağlar , Emre Göksan Pabuçcu , Müge Keskin Ahmet Hakan Haliloğlu

https://doi.org/10.18621/eurj.429257

Cited By: 2

Abstract

Objectives:
Aim of this study was to explore the effects of three
months oral anti-oxidant treatment in normozoospermic men with high DNA fragmentation
index (DFI) and recurrent intracytoplasmic sperm injection (ICSI) failures.

Methods: This is a retrospective
analyses of normozoospermic patients with high DFI levels (> 30%) with at least
two unsuccessful ICSI attempts. Among the participants, the study group included
men who had oral anti-oxidant treatment. The men who did not receive any treatment
during the study period were taken as controls. The outcomes of new ICSI cycles
were compared.

Results: During the
study period 24 men have used three months of oral anti-oxidant treatment before
a new ICSI cycle whereas the remaining 46 had ICSI-only without any other intervention.
Duration of stimulation, the number of metaphase II oocytes, fertilization
rate and implantation rates were similar between two groups. Although not statistically
significant, cases in anti-oxidant group have slightly better pregnancy rates compared
to ICSI-only group (37.5% vs 19.6%, p > 0.05). Only one case in each group
had abortion.

Conclusions: This study
reveals that there is no statistically significant difference in the ICSI outcomes
of the patients with high DFI levels, following unsuccessful ICSI attempts after
oral anti-oxidant treatment. The possible benefit derived from the anti-oxidant
therapy needs to be clarified with clinical studies with greater study populations. 

Keywords

Oxidative stress, DNA fragmentation, intracytoplasmic sperm injection, spermatozoa

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