Fibromyalgia syndrome in chronic hemodialysis patients is associated with depression, hypoalbuminemia and inflammation

Year 2019, Volume: 5 Issue: 5, 729 - 733, 04.09.2019

Bahar Gürlek Demirci Emre Tutal Mehtap Erkmen Elçin Erdoğan Siren Sezer

https://doi.org/10.18621/eurj.423605

Cited By: 1

Abstract

Objectives: Fibromyalgia syndrome (FMS) is an
entity that presents with wide-spread chronic pain in musculoskeletal system, disturbed sleep, reduced mental functioning and depressed mood. We aimed to
determine the incidence of FMS in our hemodialysis patients and to evaluate the
association between FMS, depression and inflammation in patients ongoing
hemodialysis.

Methods: Among 169 patients, 140
patients were enrolled into our study. Twenty-nine
patients were excluded according to exclusion criteria. Demographic characteristics including age, sex, body mass index,
duration of dialysis, the etiology of end stage renal disease, the dialysis
adequacy (Kt/V) were also recorded. All patients were evaluated through 2010
ACR preliminary diagnostic criteria including widespread pain index (WPI)
and total symptom severity. All subjects completed Beck
depression inventory (BDI) to determine psychological status.

Results: Among 140 hemodialysis
patients, 76 (54.2%) patients presented chronic widespread pain and 20 patients
(14.2%) met the 2010 ACR criteria for FMS. Patients were divided
into FMS (n = 20; 14.2%) and non-FMS (n = 120; 85.8%) groups. FMS group had
significantly higher serum C-reactive protein levels and lower serum albumin
levels when compared to non-FMS group. BDI (31.4 ± 1.4 vs 14.8 ± 0.6, p < 0.005), WPI (11.2 ± 0.7 vs 2.8±
0.2, p = 0.002) and symptom severity (7.3 ± 0.3 vs 3.7 ± 0.1,
p < 0.005) scores were
significantly higher in FMS group.

Conclusions: The FMS itself and the
related symptoms were correlated with depression in maintenance hemodialysis
patients. Besides, inflammation and perhaps malnutrition-inflammation sydrome
may trigger FMS in this population.

 

Keywords

Fibromyalgia, hemodialysis, depression

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