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Melatonin, Etkileri ve Kullanım Alanları

Year 2017, Volume: 28 Issue: 1, 7 - 12, 15.06.2017
https://doi.org/10.35864/evmd.530085

Abstract






 Melatonin günlük ve mevsimsel değişiklik gösterebilen pineal bezden salgılanan ve suprakiazmatik nukleus tarafından endojen ritmi düzenleyen bir hormondur. Günümüzde tıp ve veteriner hekimlikte ekzojen kullanım alanlarının genişlemesi bu hormonun önemini arttırmıştır. Hücresel kompartmanlara kolayca geçebilen bu hormon güçlü bir antioksidan özellik göstermekle beraber, sirkadyen ritmi düzenleyerek vücutta homeostazisi sağlar. Bağışıklık sistemi üzerine de olumlu etkileri bulunmaktadır. Bazı hayvan türlerinde de üreme siklusunu başlatıcı ya da inhibe edici etki gösterir. Yapılan çalışmalarla melatoninin antikanserojenik etkinliği ortaya koyulmuştur. Bu derlemede melatoninin biyokimyasal özellikleri ile kullanım alanları anlatılmaktadır.

References

  • 1. Alkan S, Horoz H, Kaşıkçı G, Sönmez C, Ak K, (2003). Kısraklarda Üreme Mevsiminin Farklı Dönemlerinde Vaginal Progesteron Uygulamalarının Fertiliteye Etkisi. İstanbul Üniversitesi Veteriner Fak Derg. 29(1), 111-17. 2. Altun A, Yaprak M, Vardar A, Aktoz M, Özbay G, (2001). Decreased nocturnal melatonin secretion in coronary artery disease (abstr). J Coronary Artery Dis. 4: 108. 3. Bendz LM, Scates AC, (2010). Melatonin Treatment for Insomnia in Pediatric patients with Attention-Deficit/ Hyperactivity Disorder. Ann Pharmacother. 44(1), 185-91. 4. Beyer CE, Steketee JD, Saphier D, (1998). Antioxidant properties of melatonin--an emerging mystery. Biochem Pharmacol. 56(10), 1265-1272. 5. Canoğlu E, Sarıbay K, (2012). Koyun ve keçilerde doğum ve jinekoloji. Semacan A, Kaymaz M, Fındık M, Rişvanlı A, Köker A. eds. Çiftlik hayvanlarında doğum ve jinekoloji. Malatya, Medipres Maatbacılık, Malatya. p.521-649. 6. Claustrat B, Brun J, Chazot G, (2005). The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 9: 11–24. 7. Claustrat B, Geoffriau M, Brun J, Chazot G, (1995). Melatonin in humans: a biochemical marker of the circadian clock and an endogenous synchronizer. Neurophysiol Clin. 25(6):351-359. 8. Crowell-Davis SL, (2007). Sexual behavior of mares. Horm Behav. 52, 12–17. 9. Czeisler CA, Shanahan TL,Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF 3rd (1995). Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 332(1), 6–11. 10. Dubocovich ML, Markowska M, (2005). Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 27, 101-110. 11. Fiorina P, Lattuada G, Silvestrini C, Ponari O, Dall’Aglio P, (1999) Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients. Scand J Immunol. 50(2), 228–231. 12. Ghosh D, Paul S, Naaz S, Bhowmik D, Dutta M, Ghosh AK, Firdaus SD, Chattopadhyay A, Reiter RJ, Bandyopadhyay D, (2016). Melatonin protects against lead acetate induced oxidative stress-mediated changes in morphology and metabolic status in rat red blood cells: a flow cytometric and biochemical analysis. J Pharm Res.10(6) ,381-402. 13. Hardeland R, Reiter RJ, Poeggeler B, Tan D-X, (1993). The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev. 17, 347-357. 14. K-Laflamme A, Wu L, de Champlain J, (1998). Impaired basal sympathetic tone and alpha 1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am J Hypertens. 11, 219-29. 15. Koçak A, Çolak A, (1996). Melatonin ve Santral Sinir Sistemi. Turgut Özal Tıp Merkezi Dergisi. 3(3), 237-244. 16. Kutzler MA, (2015). Alternative methods for feline fertility control: Use of melatonin to suppress reproduction. J Feline Med Surg. 17, 753–757 17. Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Gorevski MP, and Dubocovich ML, (2016). MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Annu. Rev. Pharmacol. Toxicol. 56, 361-383. 18. Lusardi P, Preti P, Savino S, Piazza E, Zoppi E, Fogari R, (1997). Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 2, 99- 103. 19. Molina-Carballo A, Muñoz-Hoyos A, Reiter RJ, Sánchez- Forte M, Moreno-Madrid F, Rufo-Campos M, Molina-Font JA, Acuña-Castroviejo D, (1997). Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years’experience. J Pineal Res. 23(2), 97–105. 20. Nagy P, Guillaume D, Daels P, (2000). Seasonality in mares. Anim Reprod Sci. 60-61, 245-262. 21. Nosjean O, Ferro M, Coge F, Beauverger P, Henlin JM, Lefoulon F, Fauchere JL, Delagrange P, Canet E, Boutin JA, (2000). Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 275 (40), 31311–31317. 22. Okur Gümüşova S, Memiş YS, (2014). Bazı Viral Enfeksiyonlarda Melatoninin Etkileri. Atatürk Üniversitesi Vet. Bil. Derg. 9(1), 50-54. 23. Özgüner F, Özcankaya R, Delibaş N, Koyu A, Çalışkan S, (1995). Melatonin ve klinik önemi. SDÜ tıp fakültesi Dergisi. 2(4), 1-6. 24. Öztürk L, Darıyerli N, (2000). Melatonin ve Uyku Fizyolojisi. Türkiye Tıp Derg. 7(2), 104-109. 25. Özyurtlu N, Bademkıran S, (2010). Koyunlarda Östrus Senkronizasyonu ve Östrusu Uyarma Yöntemleri. Dicle Üniv Vet Fak Derg. 1(1), 17-22. 26. Pacchierotti C, Iapichino S, Bossini L, Pieraccini F, Castrogiovanni P, (2001). Melatonin in Psychiatric Disorders: A Review on the Melatonin Involvement in Psychiatry. Front Neuroendocrinol. 22(1), 18-32. 27. Paulis L, Simko F, (2007). Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res. 56, 671-684. 28. Peltier MR, Robinson G, Sharp DC, (1998a). Effects of melatonin implants in pony mares. 2. Long-term effects. Theriogenology. 49(6), 1125-1142. 29. Peltier MR, Robinson G, Sharp DC, (1998b). Effects of melatonın ımplants ın pony mares. 1. Acute effects. Theriogenology. 49(6), 1113-1123. 30. Provinciali M, Di Stefano G, Bulian D, Tibaldi A, and Fabris N, (1996). Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice. Mech Ageing Dev. 90(1), 1–19. 31. Reiter RJ, (1991a). Neuroendocrine effects of light. Int J Biometeorol. 35, 169-175. 32. Reiter RJ, (1991b). Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocrine Reviews. 12(2), 151–80. 33. Reiter RJ, Tan DX, Osuna C, Gitto E, (2000). Actions of melatonin in the reduction of oxidative stress. J Biomed Sci. 7, 444-458. 34. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM, (2010). Melatonin: Pharmacological Aspects and Clinical Trends. Int J Neurosci. 120(9), 583-590. 35. Satué K, Gardón JC, (2013). Review of the Estrous Cycle and the Neuroendocrine Mechanisms in the Mare. J Steroids Horm Sci. 4(2),115. 36. Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 23 Suppl 1, 79-83. 37. Simonneaux V, Ribelayga C, (2003). Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters. Pharmacol Rev. 55(2), 325-395. 38. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM, (1995). Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 27(2), 355–357. 39. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP, (2008). Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs. Travel Med Infect Dis. 6(1-2), 17-28. 40. Topal T, Korkmaz A, (2009). Melatonin ve kanserle ilişkisi. Genel Tıp Derg. 19(3), 137-143. 41. Touitou Y, Le Hoang P, Claustrat B, Attye T, Auzeby A, Brun J, Bogdan A, Touitou C, (1986). Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. Neurosci Lett. 70(1), 170–174. 42. Uyar A, Alan M, (2008). Koyunlarda Erken Anöstrüs Döneminde Melatonin Uygulamalarının Ovulasyon ve Gebelik Üzerine Etkisi. YYÜ vet fak derg. 19(1), 47-54. 43. Waterhouse J, Reilly T, Atkinson G, Edwards B, (2007). Jet lag: trends and coping strategies. Lancet. 369, 1117–1129. 44. Williams GL, Thorson JF, Prezotto LD, Velez IC, Cardoso RC, Amstalden M, (2012). Reproductive seasonality in the mare: neuroendocrine basis and pharmacologic control. Domest Anim Endocrinol. 43(2), 103-115. 45. Witt-Enderby PA, Bennett J, Jarzynka MJ, Firestine S, Melan MA, (2003). Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198. 46. Wurtman RJ, Axelrod J, Chu EW, (1963). Melatonin, a pineal substance: Effect on the rat ovary. Science. 141, 277- 278. 47. Yazıcı C, Köse K, (2004). Melatonin: karanlığın antioksidan gücü. E.Ü.Journal of Health Sciences. 13(2), 56-65. 48. Yonei Y, Hattori A, Tsutsui K, Okawa M, Ishizuka B, (2010). Effects of Melatonin: Basics Studies and Clinical Applications. Anti-Aging Medicine. 7(7), 85-89.
Year 2017, Volume: 28 Issue: 1, 7 - 12, 15.06.2017
https://doi.org/10.35864/evmd.530085

Abstract

References

  • 1. Alkan S, Horoz H, Kaşıkçı G, Sönmez C, Ak K, (2003). Kısraklarda Üreme Mevsiminin Farklı Dönemlerinde Vaginal Progesteron Uygulamalarının Fertiliteye Etkisi. İstanbul Üniversitesi Veteriner Fak Derg. 29(1), 111-17. 2. Altun A, Yaprak M, Vardar A, Aktoz M, Özbay G, (2001). Decreased nocturnal melatonin secretion in coronary artery disease (abstr). J Coronary Artery Dis. 4: 108. 3. Bendz LM, Scates AC, (2010). Melatonin Treatment for Insomnia in Pediatric patients with Attention-Deficit/ Hyperactivity Disorder. Ann Pharmacother. 44(1), 185-91. 4. Beyer CE, Steketee JD, Saphier D, (1998). Antioxidant properties of melatonin--an emerging mystery. Biochem Pharmacol. 56(10), 1265-1272. 5. Canoğlu E, Sarıbay K, (2012). Koyun ve keçilerde doğum ve jinekoloji. Semacan A, Kaymaz M, Fındık M, Rişvanlı A, Köker A. eds. Çiftlik hayvanlarında doğum ve jinekoloji. Malatya, Medipres Maatbacılık, Malatya. p.521-649. 6. Claustrat B, Brun J, Chazot G, (2005). The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 9: 11–24. 7. Claustrat B, Geoffriau M, Brun J, Chazot G, (1995). Melatonin in humans: a biochemical marker of the circadian clock and an endogenous synchronizer. Neurophysiol Clin. 25(6):351-359. 8. Crowell-Davis SL, (2007). Sexual behavior of mares. Horm Behav. 52, 12–17. 9. Czeisler CA, Shanahan TL,Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF 3rd (1995). Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 332(1), 6–11. 10. Dubocovich ML, Markowska M, (2005). Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 27, 101-110. 11. Fiorina P, Lattuada G, Silvestrini C, Ponari O, Dall’Aglio P, (1999) Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients. Scand J Immunol. 50(2), 228–231. 12. Ghosh D, Paul S, Naaz S, Bhowmik D, Dutta M, Ghosh AK, Firdaus SD, Chattopadhyay A, Reiter RJ, Bandyopadhyay D, (2016). Melatonin protects against lead acetate induced oxidative stress-mediated changes in morphology and metabolic status in rat red blood cells: a flow cytometric and biochemical analysis. J Pharm Res.10(6) ,381-402. 13. Hardeland R, Reiter RJ, Poeggeler B, Tan D-X, (1993). The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev. 17, 347-357. 14. K-Laflamme A, Wu L, de Champlain J, (1998). Impaired basal sympathetic tone and alpha 1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am J Hypertens. 11, 219-29. 15. Koçak A, Çolak A, (1996). Melatonin ve Santral Sinir Sistemi. Turgut Özal Tıp Merkezi Dergisi. 3(3), 237-244. 16. Kutzler MA, (2015). Alternative methods for feline fertility control: Use of melatonin to suppress reproduction. J Feline Med Surg. 17, 753–757 17. Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Gorevski MP, and Dubocovich ML, (2016). MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Annu. Rev. Pharmacol. Toxicol. 56, 361-383. 18. Lusardi P, Preti P, Savino S, Piazza E, Zoppi E, Fogari R, (1997). Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 2, 99- 103. 19. Molina-Carballo A, Muñoz-Hoyos A, Reiter RJ, Sánchez- Forte M, Moreno-Madrid F, Rufo-Campos M, Molina-Font JA, Acuña-Castroviejo D, (1997). Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years’experience. J Pineal Res. 23(2), 97–105. 20. Nagy P, Guillaume D, Daels P, (2000). Seasonality in mares. Anim Reprod Sci. 60-61, 245-262. 21. Nosjean O, Ferro M, Coge F, Beauverger P, Henlin JM, Lefoulon F, Fauchere JL, Delagrange P, Canet E, Boutin JA, (2000). Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 275 (40), 31311–31317. 22. Okur Gümüşova S, Memiş YS, (2014). Bazı Viral Enfeksiyonlarda Melatoninin Etkileri. Atatürk Üniversitesi Vet. Bil. Derg. 9(1), 50-54. 23. Özgüner F, Özcankaya R, Delibaş N, Koyu A, Çalışkan S, (1995). Melatonin ve klinik önemi. SDÜ tıp fakültesi Dergisi. 2(4), 1-6. 24. Öztürk L, Darıyerli N, (2000). Melatonin ve Uyku Fizyolojisi. Türkiye Tıp Derg. 7(2), 104-109. 25. Özyurtlu N, Bademkıran S, (2010). Koyunlarda Östrus Senkronizasyonu ve Östrusu Uyarma Yöntemleri. Dicle Üniv Vet Fak Derg. 1(1), 17-22. 26. Pacchierotti C, Iapichino S, Bossini L, Pieraccini F, Castrogiovanni P, (2001). Melatonin in Psychiatric Disorders: A Review on the Melatonin Involvement in Psychiatry. Front Neuroendocrinol. 22(1), 18-32. 27. Paulis L, Simko F, (2007). Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res. 56, 671-684. 28. Peltier MR, Robinson G, Sharp DC, (1998a). Effects of melatonin implants in pony mares. 2. Long-term effects. Theriogenology. 49(6), 1125-1142. 29. Peltier MR, Robinson G, Sharp DC, (1998b). Effects of melatonın ımplants ın pony mares. 1. Acute effects. Theriogenology. 49(6), 1113-1123. 30. Provinciali M, Di Stefano G, Bulian D, Tibaldi A, and Fabris N, (1996). Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice. Mech Ageing Dev. 90(1), 1–19. 31. Reiter RJ, (1991a). Neuroendocrine effects of light. Int J Biometeorol. 35, 169-175. 32. Reiter RJ, (1991b). Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocrine Reviews. 12(2), 151–80. 33. Reiter RJ, Tan DX, Osuna C, Gitto E, (2000). Actions of melatonin in the reduction of oxidative stress. J Biomed Sci. 7, 444-458. 34. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM, (2010). Melatonin: Pharmacological Aspects and Clinical Trends. Int J Neurosci. 120(9), 583-590. 35. Satué K, Gardón JC, (2013). Review of the Estrous Cycle and the Neuroendocrine Mechanisms in the Mare. J Steroids Horm Sci. 4(2),115. 36. Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 23 Suppl 1, 79-83. 37. Simonneaux V, Ribelayga C, (2003). Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters. Pharmacol Rev. 55(2), 325-395. 38. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM, (1995). Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 27(2), 355–357. 39. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP, (2008). Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs. Travel Med Infect Dis. 6(1-2), 17-28. 40. Topal T, Korkmaz A, (2009). Melatonin ve kanserle ilişkisi. Genel Tıp Derg. 19(3), 137-143. 41. Touitou Y, Le Hoang P, Claustrat B, Attye T, Auzeby A, Brun J, Bogdan A, Touitou C, (1986). Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. Neurosci Lett. 70(1), 170–174. 42. Uyar A, Alan M, (2008). Koyunlarda Erken Anöstrüs Döneminde Melatonin Uygulamalarının Ovulasyon ve Gebelik Üzerine Etkisi. YYÜ vet fak derg. 19(1), 47-54. 43. Waterhouse J, Reilly T, Atkinson G, Edwards B, (2007). Jet lag: trends and coping strategies. Lancet. 369, 1117–1129. 44. Williams GL, Thorson JF, Prezotto LD, Velez IC, Cardoso RC, Amstalden M, (2012). Reproductive seasonality in the mare: neuroendocrine basis and pharmacologic control. Domest Anim Endocrinol. 43(2), 103-115. 45. Witt-Enderby PA, Bennett J, Jarzynka MJ, Firestine S, Melan MA, (2003). Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198. 46. Wurtman RJ, Axelrod J, Chu EW, (1963). Melatonin, a pineal substance: Effect on the rat ovary. Science. 141, 277- 278. 47. Yazıcı C, Köse K, (2004). Melatonin: karanlığın antioksidan gücü. E.Ü.Journal of Health Sciences. 13(2), 56-65. 48. Yonei Y, Hattori A, Tsutsui K, Okawa M, Ishizuka B, (2010). Effects of Melatonin: Basics Studies and Clinical Applications. Anti-Aging Medicine. 7(7), 85-89.
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Details

Primary Language Turkish
Journal Section Issue
Authors

Ayris Salt This is me

Metin Çenesiz 0000-0003-2494-1959

Sena Çenesiz This is me

Publication Date June 15, 2017
Submission Date February 21, 2019
Published in Issue Year 2017 Volume: 28 Issue: 1

Cite

APA Salt, A., Çenesiz, M., & Çenesiz, S. (2017). Melatonin, Etkileri ve Kullanım Alanları. Etlik Veteriner Mikrobiyoloji Dergisi, 28(1), 7-12. https://doi.org/10.35864/evmd.530085

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