DNA İmmunization

Year 1999, Volume: 10 Issue: 2, 73 - 85, 01.12.1999

Barış Sareyyüpoğlu Müjgan İzgür

Abstract

DNA immunization represents a new and promising approach
for the prevention and therapy of many infectious and non-infectious
diseases. With this approach, vaccines made of DNA are being developed
as a form of gene therapy that use the patient's own cellular
machinery to make foreign proteins that stimulate an immune response.
Direct inoculations of vaccine DNAs (which are produced by
doning DNA sequences encoding the protein or proteins to be used
as immunogens into an eukaryotic expressian vector, in other words.
by the help of the recombinant technology) into animals generate antibody,
cytotoxic T cell (CTL) and protective immune respanses that
have good longevity, with even single doses of DNA. Protective immune
respanses can be generated by skin and muscle inoculations of
DNA. Immunizations can be accomplished by injecting DNA in saline,
or by using a gene gun topropel DNA-coated gold beads into cells. In
this paper DNA vaccine production, vaccination techniques, current
and potential uses of DNA immunization were reviewed. A comparison between DNA-mediated and conventional vaccination by evaluating
its advantages and disadvantages were also mentioned.

DNA İmmunizasyonu

Abstract

DNA immunizasyonu birçok infeksiyöz ve infeksiyöz olmayan
hastalıklardan korunma ve bunların sağaltımları için yeni ve umut
vadeden bir yaklaşım sunmaktadır. Bu derlernede DNA aşısı üretimi,
aşılama teknikleri ve DNA aşılarının kullanım alanları gözden geçirildi.
DNA aşılarının avantaj ve dezavantajları da değerlendirilerek konvansiyonel
aşılarla karşılaştırılması yapıldı.

Keywords

DNA, İmmunizasyon, 1999, Etlik Veteriner Mikrobiyoloji Dergisi

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