Effects of Dichlorvos in Small Intestine Tissue of Rats and Protective Role of Vitamins C and E

Year 2008, Volume: 19 Issue: 1, 47 - 52, 01.06.2008

Ayşenur Çetin Yavuz Ulusoy Ayşe Öğütçü Fatma Gökçe Uzun Filiz Demir

Abstract

Dichlorvos, an organophosphorus pesticide, is widely used in agricultural control. In the present study, vitamin C
(200mg/kg)+vitamin E (200mg/kg), dichlorvos (1,6mg/kg) and vitamin C (200mg/kg)+vitamin E (200mg/kg)+dichlorvos were given
to male rats orally for 7 weeks. Histopathological changes in the small intestine tissues were investigated using light microscope at
the end of 24h, 4th and 7th weeks comparatively with control group. After 4 and 7 weeks of dichlorvos exposure shortening and dilatation
were observed in intestinal villi. Same histopathological changes in the small intestine tissues were observed at the end of 24h,
4th and 7th weeks.
As a result, lower doses of dichlorvos caused histopathological changes in the rat small intestine tissues. It’s determined that vitamin
C and vitamin E haven’t prevented the pathological changes caused by dichlorvos in small intestine tissue.

Dichlorvos’un Ratların İnce Bağırsak Dokusu Üzerine Etkisi ve Vitamin C ve E’nin Koruyucu Rolü

Abstract

Organofosforlu bir pestisit olan dichlorvos zirai zararlıların kontrolünde yaygın olarak kullanılmaktadır. Bu çalışmada vitamin
C (200mg/kg)+vitamin E (200mg/kg), dichlorvos (1,6mg/kg) ve vitamin C (200mg/kg)+vitamin E (200mg/kg)+dichlorvos erkek
ratlara oral olarak 7 hafta süre ile uygulandı. Muameleden 24 saat, 4 hafta ve 7 hafta sonra ratların ince bağırsak dokularındaki
histopatolojik değişiklikler ışık mikroskobu kullanılarak, kontrol grubu ile mukayeseli olarak incelendi. Dichlorvos uygulandıktan 4
ve 7 hafta sonra ince bağırsakta villuslarda kısalma ve genişleme tespit edildi. Vitamin C+vitamin E+dichlorvos uygulanan ratların
ince bağırsak dokularında da benzer patolojik değişiklikler gözlendi.
Sonuç olarak düşük doz dichlorvos ratların ince bağırsak dokularında patolojik değişikliklerin oluşmasına yol açmaktadır. Vitamin
C ve vitamin E’nin, dichlorvosun ince bağırsak dokusunda meydana getirdiği patolojik değişiklikleri önleyemediği tespit edildi.

Keywords

Etlik Veterinerlik Mikrobiyoloji Dergisi, Dichlorvos, İnce Bağırsak, Doku, Vitamin C, Vitamin E, Ayşenur ÇETİN, Yavuz ULUSOY, Ayşe ÖĞÜTÇÜ, Fatma Gökçe UZUN, Filiz DEMİR, 2008

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