Kanatlı Salmonella Aşılarına Farklı Perspektiften Bakış

Yıl 2008, Cilt: 19 Sayı: 1, 63 - 68, 01.06.2008

Elçin Günaydın

Öz

Salmonella infeksiyonlarından korunmada aşılama oldukça güçlü bir araçtır. Daha etkili ve daha güvenli Salmonella aşılarının
geliştirilmesine ihtiyaç duyulmaktadır. Salmonella virulensinin genetiği hakkında elde edilen bilgiler ve modern rekombinant
DNA teknolojisi; çoklu, belirlenmiş, attenüe ve irreversible mutasyonların bakteri genomu içerisine dahil edilmesi gerekliliği üzerinde
durmaktadır. Bu genler bakteriyel yapısal komponentlerin (Lipopolisakkarit; LPS, dış membran proteini; outer membran proteini,
OMP) veya temel metabolitlerin (aromatik aminoasit, purin, primidinhistidin) biyosentezinden sorumlu olan ‘house-keeping genes’
olarak adlandırılan genlerdir. Salmonella’nın konak içinde hayatta kalabilmesini sağlayan çok sayıda gen identifiye edilmiştir. Bu
genlerde meydana getirilen mutasyonlarla yeni aşı suşları denenmiştir.

Anahtar Kelimeler

Etlik Veterinerlik Mikrobiyoloji Dergisi, Kanatlı, Salmonella, Aşı, Perspektif, Elçin GÜNAYDIN, 2008

View at Poultry Salmonella Vaccines With Different Perspective

Öz

Vaccination is a powerful tool for the protection of Salmonella infections. There is a need to develop more effective
and more reliable Salmonella vaccines. The knowledge achieved about the genetics of Salmonella virulence and modern recombinant
DNA technology dwell upon a subject of the necessity of inserting multiple, specified, attenued and irreversible mutations into the
bacterial genome. These genes, responsible for biosynthesis of bacterial basic structural components (Lipopolisaccharide; LPS, outer
membran protein; OMP) or basic metabolits (aromatic aminoasit, purin, primidinhistidin) are termed as house-keeping genes. Many
genes, eliciting survival of Salmonella into the host were identified. New vaccine strains were experienced by the mutations achieved
in the genes.

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