Immune response in cattle simultaneously vaccinated with foot and mouth disease (FMD) and bovine ephemeral fever vaccines (BEF)

Yıl 2022, Cilt: 33 Sayı: 2, 21 - 29, 23.12.2022

Veli Gülyaz , Ahu Kader Kara , Osman Erganiş , Osman Kara , Beyhan Sareyyüpoğlu , Abdullah Arslan , Mustafa Hasöksüz , Gonca Öztap , Mehmet Yalvaç

https://doi.org/10.35864/evmd.1136413

Cited By: 1

Öz

Bovine ephemeral fever (BEF) virus is an arthropod-borne rhabdovirus and causing an acute febrile illness disease in cattle and water buffalo. Foot-and-mouth disease (FMD) is a highly infectious viral disease of mammals and has a great potential for causing severe economic loss in susceptible cloven-hoofed animals. FMD and BEF vaccines are widely used in countries where both diseases are seen together. This study was carried out to determine the immunological response of cattle simultaneously vaccinated with BEF and FMD vaccines. For this purpose, the cattle were divided into 4 groups in this study as single FMD vaccination group (Group 1; n=10), single BEF vaccination group (Group 2; n=10), BEF+FMD simultaneously vaccinated group (Group 3; n=10) and unvaccinated control group (Group 4; n=10). After the first vaccinations, booster BEF vaccine was applied to the cattle in groups 2 and 3. Although there was no increase in the neutralizing antibody titers against BEF and FMD virus in the blood serums of unvaccinated cattle on the 30th and 60th days of vaccination, There were significant increases in statistically protective neutralizing antibody levels in the vaccinated cattle. As a result, it was demonstrated with this study that BEF and FMD vaccines can be applied simultaneously to combat both diseases in cattle.

Anahtar Kelimeler

FMDV, BEFV, vaccine, immunity, cattle

Destekleyen Kurum

This project was supported by the General Directorate of Agricultural Research and Policies (TAGEM) affiliated to the Ministry of Agriculture and Forestry.

Proje Numarası

TAGEM/HSGYAD/Ü/19/A5/P1/1306.

Teşekkür

This project was supported by the General Directorate of Agricultural Research and Policies (TAGEM) affiliated to the Ministry of Agriculture and Forestry. TAGEM/HSGYAD/Ü/19/A5/P1/1306. We would like to thank to the veterinarian; Eylem ARAS UZUN, Aydın TAŞLI, Ceylan GÜNDÜZALP and Biolog; Banu BAYRİ ÖZBİLGE for their contributions in this study.

Şap hastalığı (FMD) ve üç gün hastalıklarına (BEF) karşı eş zamanlı aşılanmış sığırlarda bağışıklık yanıt

Öz

Sığırların üç hastalığı (BEF) virüsü, artropod kaynaklı bir rabdovirüs olup, sığır ve mandalarda akut ateşli enfeksiyona sebep olur. Şap hastalığı (FMD), memelilerin oldukça bulaşıcı bir viral hastalığıdır ve hassas çift tırnaklı hayvanlarda ciddi ekonomik kayıplara neden olma konusunda büyük bir potansiyele sahiptir. Şap ve BEF aşıları, her iki hastalığın birlikte görüldüğü ülkelerde yaygın olarak kullanılmaktadır. Bu çalışma, BEF ve FMD aşıları ile eş zamanlı olarak aşılanan sığırların immünolojik yanıtını belirlemek amacıyla yapılmıştır. Bu amaçla sığırlar bu çalışmada tekli Şap aşısı grubu (Grup 1; n=10), tekli BEF aşısı grubu (Grup 2; n=10), BEF+Şap ile eş zamanlı aşılı grup (Grup 3; n=10) ve aşısız kontrol grubu (Grup 4; n=10) olmak üzere 4 gruba ayrıldı. Grup 2 ve 3'teki sığırlara ilk aşılamalardan sonra booster BEF aşısı uygulandı. Çalışma sonucu aşısız sığırların kan serumlarında aşılamanın 30. ve 60. günlerinde BEF ve FMD virüsüne karşı nötralize edici antikor titrelerinde artış olmamasına rağmen, aşılanmış sığırlarda istatistiksel olarak koruyucu nötralize edici antikor seviyelerinde önemli artışlar tespit edilmiştir. Sonuç olarak bu çalışma ile sığırlarda her iki hastalıkla mücadelede BEF ve FMD aşılarının aynı anda uygulanabileceği gösterilmiştir.

Anahtar Kelimeler

FMDV, BEFV, aşı, bağışıklık, sığır

Proje Numarası

TAGEM/HSGYAD/Ü/19/A5/P1/1306.

Kaynakça

• Referans1. Abayli H, Tonbak S, Azkur A.K, Bulut H. (2017) Complete genome analysis of highly pathogenic bovine ephemeral fever virus isolated in Turkey in 2012. Arch Virol. 162, 3233-3238. https://doi.org/10.1007/s00705-017-3470-6
• Referans2. Abubakar M, Arshed MJ, Ali Q, Hussain M. (2012) Spatial trend of foot and mouth disease virus (FMDV) serotypes in cattle and buffaloes, Pakistan. Virol Sin. 27, 320-323. https://doi.org/10.1007/s12250-012-3271-8
• Referans3. Ahmed H I, Farooq U, Zahur A B, Naeem K, Latif A, Irhsad H. (2017) Evidence of foot-and-mouth disease virus excretion in the milk of apparently healthy vaccinated buffaloes in Islamabad, Pakistan. Turk J Vet Anim Sci. 41, 431-434. https://doi.org/ 10.3906/vet-1512-96
• Referans4. Alkan F, Albayrak H, Timurkan MO, Ozan E, Coskun N. (2017) Assessment of the molecular epidemiology of bovine ephemeral fever in Turkey. Vet Arhiv. 87 (6), 665-675. https://doi.org/10.24099/vet.arhiv.160711
• Referans5. Ammerman N C, Sexton M B and Azad A F. (2008) Growth and maintenance of vero cell lines. Curr Protoc Microbiol. available in PMC 2019. https://doi.org/ 10.1002/9780471729259.mca04es1.
• Referans6. Aziz-Boaron O, Gleser D, Yadin H, Gelman B, Kedmi M, Galon N, Klement E. (2014) The protective effectiveness of an inactivated bovine ephemeral fever virus vaccine. Vet Microbiol. 173, 1-8. https://doi.org/10.1016/j.vetmic.2014.06.021.
• Referans7. Aziz-Boaron O, Leibovitz K, Gelman B, Kedmi M, Klemen E. (2013) Safety, immunogenicity and duration of immunity elicited by an ınactivated bovine ephemeral fever vaccine. Plos one. Vol. 8 (12)| e82217. https://doi.org/10.1371/journal.pone.0082217.
• Referans8. Aziz-Boaron O, Brettschneider S, King R. (2015). Seroprevalence of Bovine Ephemeral Fever Virus in Domesticated and Wildlife Species during Epidemic and Inter-epidemic Periods (2000–2009) in Israel. Transbound Emerg Dis. 62, 183-187. https://doi.org/10.1111/tbed.12104.
• Referans9. Basagoudanavar S H, Hosamani M, Tamil Selvan R P, Sreenivasa BP, Saravanan P, Chandrasekhar Sagar BK, Venkataramanan R. (2013) Development of a liquid-phase blocking ELISA based on foot-and-mouth disease virus empty capsid antigen for seromonitoring vaccinated animals. Arch Virol. 158, 993-1001. https://doi.org/ 10.1007/s00705-012-1567-5.
• Referans10. Chaisirirat T, Sangthong P, Arunvipas P, Petcharat N, Thangthamniyom N, Chumsing W, Lekcharoensuk P. (2018) Molecular Characterization of Bovine Ephemeral Fever Virus in Thailand between 2013 and 2017. Vet Microbiol. 227, 1-7. https://doi.org/ 10.1016/j.vetmic.2018.10.013
• Referans11. Çokçalışkan C, Göktuna PT, Türkoğlu T, Uzunlu E, Gündüzalp C, Aras Uzun E, Sareyyüpoğlu B, Kürkçü A, Gülyaz V. (2019) Effect of simultaneous administration of foot-and-mouth disease (FMD) and anthrax vaccines on antibody response to FMD in sheep. Clin Exp Vaccine Res. 8(2), 103-109. https://doi.org/10.7774/cevr.2019.8.2.103
• Referans12. El-Habbaa AS, Radwan ME. (2019) Detection and genetic analysis of bovine ephemeral fever virus G gene in buffy coat samples from cattle at Qualyubia, Egypt 2017. J Virol Sci. 5, 55-65.
• Referans13. El-Bagoury GF, El-Habbaa AS, Gamil MA, Fawzy H.G. (2014) Evaluatıon of an ınactivated combined oil vaccıne prepared for foot and mouth disease and bovine ephemeral fever viruses. BVMJ. 27(1), 221‐231.
• Referans14. Erganiş O, Yavru S, Sayin Z, et al., (2010) The development of vaccine for bovine ephemeral fever infection. In: 9th National Veterinary Microbiology Congress, Lefkose, Republic of North Cyrpus.
• Referans15. Erol N, Koç BT, Gür S, Çağlav VO, Tan MT. (2015) Aydın ve Muğla İlleri’nde Bovine Ephemeral Fever Virus Enfeksiyonu’nun Serolojik Olarak Araştırılması. Kocatepe Vet J. 8(2), 45-49. https://doi.org/ 02175570010156
• Referans16. Girgin H, Yonguc AD, Akcora A, (1986) First outbreak of bovine ephemeral fever in Turkey (Türkiye’de ilk bovine ephemeral fever salgını). Etlik Vet Mikrobiyol Enst Derg. 5, 5-12. https://dergipark.org.tr/tr/pub/evmd/issue/61195/734436.
• Referans17.Hussain A, Abubakar M, Shah H, Arshed MJ, Hussain M, Afzal M. (2017) Socioeconomic impact of foot and mouth disease vaccination in Pakistan. Pak J Life Soc Sci. 15(3), 183-191.
• Referans18. Ibrahim M.M, El Zieny A, Christine A. (2016) Further evaluation of locally prepared live attenuated bovine ephemeral fever vaccine in cattle. VSVRI. 23(2),174- 183.
• Referans19. Kasem S, Abdel Fatah S, Khodier M Desouky A. (2017) Evaluation of the Efficacy of Simultaneous Vaccination of Cattle Against Rabies and Foot and Mouth Disease Viruses. Global Veterinaria. 18 (3), 226-233. https://doi.org/10.5829/idosi.gv.2017.226.233.
• Referans20. Karaoğlu T, Ozgünlük I, Demir B, Ozkul A, Burgu I. (2007) Seroprevalence of culicoides-borne disease in cattle in European Turkey. Ankara Univ Vet Fak Derg. 54,121-125. https://doi.org/10.1501/Vetfak_0000000266.
• Referans21. Mirzaie K, Bahonar A, Mehrabadi M.F, Hajilu G, Yaghoubi M. (2017) Determinants of bovine ephemeral fever outbreak during 2013, in Qazvin Province, Iran. Asian Pac J Trop Dis. 7(12), 744-747. https://doi.org./10.12980/apjtd.7.2017D7-22.
• Referans22. Oğuzoğlu TC, Ertürk A, Cizmeci SG, Koç BT, Akça Y. (2015) A report on bovine ephemeral fever virus in Turkey: Antigenic variations of different strains of EFV in the 1985 and 2012 outbreaks using partial glycoprotein gene sequences. Transboundary and Emerging Diseases. 62. https://doi.org/10.1111/tbed.12187.
• Referans23. OIE, (2021). OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. Terrestrial manual: foot and mouth disease: OIE terrestrial manual, Chapter 3.1.8. https://www.woah.org/en/what-we-do/standards/codes-and-manuals/terrestrial-manual-online-access.
• Referans24. Sareyyüpoğlu B, Gülyaz V, Cokçalışkan C, Ünal Y, Çökülgen T, Uzunlu E, Gürcan S, İlk O. (2019) Effect of FMD vaccination schedule of dams on the level and duration of maternally derived antibody. Veterinary Immunology and Immunopathology Vol: 217. https://doi.org/10.1016/j.vetimm.2019.109881.
• Referans25. Srinivasan VA, Reddy GS, Rao KA, Kihm U. (2001) Serological response of bovines to combined vaccine containing foot and mouth disease virus, rabies virus, Pasteurella multocida and Clostridium chauvoei antigens. Vet Arhıv. 71(1), 37-45.
• Referans26. Tekleghiorghis T, Weerdmeester K, Hemert-Kluitenberg FV, Moormann RJM, Dekker A. (2014) Comparison of test methodologies for foot-and-mouth disease virus serotype A vaccine matching. Clinical and Vaccine Immunology. 21(5), 674-683. https://doi.org/ 10.1128/CVI.00034-14.
• Referans27. Tonbak S, Berber E, Yoruk MD, Azkur AK, Pestil Z, Bulut H. (2013) A large-scale outbreak of bovine ephemeral fever in Turkey, 2012. J. Vet Med Sci. 75(11), 1511-1514. https://doi.org/ 10.1292/jvms.13-0085.
• Referans28. Trotta M, Lahore J, Cardoso N, Melucci O, Catena M, Perez-Filgueira M, Fernandez F, Capozzo AV. (2015) Simultaneous immunization of cattle with foot-and-mouth disease (fmd) and live anthrax vaccines do not interfere with FMD booster responses. Trials in vaccinology. 4, 38-42. https://doi.org/10.1016/j.trivac.2015.04.001.
• Referans29. Tzıporı S, Spradbrow PB and Doyle VT, (1975) Laboratory and fıeld studıes wıth a bovine ephemeral fever vaccine. Aust Vet J. Vol. 51. https://doi.org/10.1111/j.1751-0813.1975.tb06924.x
• Referans30. Tzıporı S, Spradbrow PB. (1978) A cell culture vaccıne agaınst bovıne ephemeral fever. Aust Vet J. Vol. 54. https://doi.org/10.1111/j.1751-0813.1978.tb02480.x.
• Referans31. Walker PJ, Klement E, (2015) Epidemiology and control of bovine ephemeral fever. Vet Res. 46, 124. https://doi.org/10.1186/s13567-015-0262-4.
• Referans32. Vanselow BA, Walthall JC, Abetz I, (1995) Field trials of ephemeral fever vaccines. Vet Microbiol. 46 (1-3), 117-30. https://doi.org/10.1016/0378-1135(95)00077-n.
• Referans33. Yang D-K, Kim H-H, Jo H-Y, Choi SS, Cho In-S. (2015) Development of inactivated Akabane and bovine ephemeral fever vaccine for cattle. Korean J Vet Res. 55(4), 227-232. https://doi.org/ 10.14405/kjvr.2015.55.4.227.
• Referans34. Yeruham I, Van Ham M, Stram Y, Friedgut O, Yadin H, Mumcuoglu KY, Braverman Y. (2010) Epidemiological Investigation of Bovine Ephemeral Fever Outbreaks in Israel. Vet Med Int. Article ID 290541. https://doi.org/10.4061/2010/290541.
• Referans35. Zheng F,Qiu C. (2012) Phylogenetic relationships of the glycoprotein gene of bovine ephemeral fever virus isolated from mainland China, Taiwan, Japan, Turkey, Israel and Australia. Virol J. 9, 268. https://doi.org/10.1186/1743-422X-9-268.