Endometriyal Reseptiviteyi Anlamak: Başarılı İmplantasyonda Önemli Bir Faktör

Year 2023, , 39 - 43, 30.12.2023

Deniz Kulaksız

https://doi.org/10.59518/farabimedj.1306708

Abstract

Embriyonun başarılı bir şekilde implantasyonu, sağlıklı bir hamilelik elde etmede çok önemli bir kilometre taşıdır. Endometriumun, embriyo implantasyonuna açık hale geldiği kısa dönem olan implantasyon penceresi, bu sürecin başarısını veya başarısızlığını belirlemede çok önemli bir rol oynar. Bu makale, endometrial reseptiviteyi etkileyen faktörlere ve bunun başarılı implantasyon elde etmedeki önemine kapsamlı bir genel bakış sunmayı amaçlamaktadır. İmplantasyon penceresi sırasında endometriyumda meydana gelen fizyolojik değişiklikler, hormonal, moleküler ve hücresel olaylar karmaşık bir etkileşim göstermektedir. Başta östrojen ve progesteron olmak üzere yumurtalık hormonlarının bu değişiklikleri yönetmedeki kritik rolü vardır ve bunların endometrial büyüme, farklılaşma ve reseptivite üzerindeki etkileri vardır. Endometriyal reseptivite için çeşitli moleküler belirteçler ve sinyal yolları mevcuttur. Bunlar integrinleri, adezyon moleküllerini, sitokinleri, büyüme faktörlerini ve bunların etkileşimlerini içerir; bunların hepsi embriyo tutunması ve invazyon için çok önemlidir. Anormal endometriyal reseptivitenin implantasyon başarısızlığı, tekrarlayan gebelik kaybı ve kısırlık üzerinde etkisi bulunmaktadır. Sonuç olarak, endometrial reseptiviteyi yöneten karmaşık mekanizmaların anlaşılması, reprodüktif sonuçların iyileştirilmesi için çok önemlidir. Reseptivitenin değerlendirilmesi ve optimize edilmesi ile doğurganlık tedavilerinin başarı oranlarını artırma mümkün olabilir.

Keywords

Endometriyal reseptivite, HOXA10, Kısırlık

Understanding Endometrial Receptivity: A Key Factor in Successful Implantation

Abstract

Successful implantation of the embryo is a crucial milestone in achieving a healthy pregnancy. The implantation window, the short period in which the endometrium becomes open to embryo implantation, plays a crucial role in determining the success or failure of this process. This article aims to provide a comprehensive overview of the factors affecting endometrial receptivity and its importance in achieving successful implantation. Physiological changes, hormonal, molecular and cellular events that occur in the endometrium during the implantation window show a complex interaction. Ovarian hormones, particularly estrogen and progesterone, have a critical role in managing these changes and have effects on endometrial growth, differentiation, and receptivity. Various molecular markers and signaling pathways exist for endometrial receptivity. These include integrins, adhesion molecules, cytokines, growth factors and their interactions; All of these are very important for embryo attachment and invasion. Abnormal endometrial receptivity has implications for implantation failure, recurrent pregnancy loss, and infertility. In conclusion, understanding the complex mechanisms governing endometrial receptivity is crucial for improving reproductive outcomes. By evaluating and optimizing receptivity, it may be possible to increase the success rates of fertility treatments.

Keywords

Endometrial receptivity, HOXA10, Infertility

References

• Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006; 12(6): 731-746. DOI: 10.1093/humupd/dml004.
• Celik O, Unlu C, Muderris I, Celik N. The art of understanding endometrium. Vol 1.; 2019.
• Apparao KB, Murray MJ, Fritz MA, et al. Osteopontin and its receptor alphavbeta(3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab. 2001; 86(10): 4991-5000. DOI: 10.1210/jcem.86.10.7906.
• Salleh N, Giribabu N. Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception. ScientificWorldJournal. 2014; 2014: 201514. DOI: 10.1155/2014/201514.
• Shah NM, Lai PF, Imami N, Johnson MR. Progesterone-related immune modulation of pregnancy and labor. Front Endocrinol (Lausanne). 2019; 10:198. DOI: 10.3389/fendo.2019.00198.
• He B, Ni ZL, Kong SB, Lu JH, Wang HB. Homeobox genes for embryo implantation: From mouse to human. Animal Model Exp Med. 2018; 1(1): 14-22. DOI: 10.1002/ame2.12002.
• Rubin SC, Abdulkadir M, Lewis J, Harutyunyan A, Hirani R, Grimes CL. Review of endometrial receptivity array: a personalized approach to embryo transfer and its clinical applications. J Pers Med. 2023; 13(5): 749. DOI: 10.3390/jpm13050749.
• Hosseinzadeh P, Barsky M, Gibbons WE, Blesson CS. Polycystic ovary syndrome and the forgotten uterus. F S Rev. 2021; 2(1): 11-20. DOI: 10.1016/j.xfnr.2020.12.001.
• Heger A, Sator M, Pietrowski D. Endometrial receptivity and its predictive value for IVF/ICSI-outcome. Geburtshilfe Frauenheilkd. 2012; 72(8): 710-715. DOI: 10.1055/s-0032-1315059.
• Kwak Y, Kim Y, Baek KA. Prevalence of irregular menstruation according to socioeconomic status: A population-based nationwide cross-sectional study. PLoS One. 2019; 14(3): e0214071. DOI: 10.1371/journal.pone.0214071.
• Jain V, Chodankar RR, Maybin JA, Critchley HOD. Uterine bleeding: how understanding endometrial physiology underpins menstrual health. Nature reviews endocrinology. 2022; 18(5): 290-308. DOI: 10.1038/s41574-021-00629-4.
• Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet. 2012; 29(11): 1227-1239. DOI: 10.1007/s10815-012-9861-4.
• Lessey BA, Kim JJ. Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. Fertil Steril. 2017; 108(1): 19-27. DOI: 10.1016/j.fertnstert.2017.05.031.
• Golovinskaia O, Wang CK. Review of Functional and Pharmacological Activities of Berries. Molecules. 2021; 26(13): 3904. DOI: 10.3390/molecules26133904.
• Abdel-Aal el-SM, Akhtar H, Zaheer K, Ali R. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients. 2013; 5(4): 1169-1185. DOI: 10.3390/nu5041169.
• Adebukola Adeyanju A, Rebecca Oyenihi O, Omoniyi Oguntibeju O. Antioxidant-rich vegetables: impact on human health. In: Vegetable crops - health benefits and cultivation. IntechOpen; 2022. DOI: 10.5772/intechopen.101126.
• Li MY, Liu HY, Wu DT, et al. L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications. Front Nutr. 2022; 9: 853846. DOI: 10.3389/fnut.2022.853846.
• Sharifi-Rad J, Rayess YE, Rizk AA, et al. Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol. 2020;11:01021. DOI: 10.3389/fphar.2020.01021.
• Gambineri A, Laudisio D, Marocco C, et al. Female infertility: which role for obesity?. Int J Obes Suppl. 2019; 9(1): 65-72. DOI: 10.1038/s41367-019-0009-1.
• Ranjan P, Baboo AGK, Anwar W, et al. Physical activity, yoga, and exercise prescription for postpartum and midlife weight management: A practical review for clinicians. J Obstet Gynaecol India. 2022; 72(2): 104-113. DOI: 10.1007/s13224-022-01627-w.
• de Angelis C, Nardone A, Garifalos F, et al. Smoke, alcohol and drug addiction and female fertility. Reprod Biol Endocrinol. 2020; 18(1): 21. DOI: 10.1186/s12958-020-0567-7.
• Lateef OM, Akintubosun MO. Sleep and reproductive health. J Circadian Rhythms. 2020; 18:1. DOI: 10.5334/jcr.190.
• Bu FL, Feng X, Yang XY, Ren J, Cao HJ. Relationship between caffeine intake and infertility: a systematic review of controlled clinical studies. BMC Womens Health. 2020; 20(1): 125. DOI:10.1186/s12905-020-00973-z.
• Garcia-Garcia D. Health promotion and hydration: a systematic review about hydration care. Florence Nightingale J Nurs. 2022; 30(3): 310-321. DOI: 10.5152/FNJN.2022.21313.
• Sutton P, Woodruff TJ, Perron J, et al. Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures. Am J Obstet Gynecol. 2012; 207(3): 164-173. DOI: 10.1016/j.ajog.2012.01.034.
• Gaskins AJ, Chavarro JE. Diet and fertility: a review. Am J Obstet Gynecol. 2018; 218(4): 379-389. DOI: 10.1016/j.ajog.2017.08.010.
• Várbíró S, Takács I, Tűű L, et al. Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review. Nutrients. 2022; 14(8): 1649. DOI: 10.3390/nu14081649.
• Md Amin NA, Sheikh Abdul Kadir SH, Arshad AH, Abdul Aziz N, Abdul Nasir NA, Ab Latip N. Are Vitamin E supplementation beneficial for female gynaecology health and diseases? Molecules. 2022; 27(6): 1896. DOI: 10.3390/molecules27061896.
• Qi S, Liang Q, Yang L, Zhou X, Chen K, Wen J. Effect of Coenzyme Q10 and transcutaneous electrical acupoint stimulation in assisted reproductive technology: a retrospective controlled study. Reproductive Biology and Endocrinology. 2022; 20(1): 167. DOI: 10.1186/s12958-022-01043-9.