Obstrüktif Uyku Apnesinin (OUA) Derin Uyku (N3) Delta Güç Spektral Yoğunluğu Üzerindeki Etkisinin Karşılaştırmalı Analizi

Öz

Obstrüktif Uyku Apnesi (OUA), kronik uyku bölünmesi ve aralıklı hipoksi ile karakterize yaygın bir bozukluktur. Bu çalışmanın amacı, sağlıklı bireyler ile OUA hastaları arasındaki Derin Uyku (N3) delta güç spektral yoğunluğunu (PSD) nicel yöntemlerle karşılaştırmaktır. Çalışmada, istatistiksel gücü artırmak için PhysioNet CAP (Sağlıklı) ve UCD Sleep Apnea (Hasta) veri tabanları birleştirilerek hibrit bir set oluşturulmuş, santral bölgeden (C4/C3) kaydedilen tek kanallı kafa derisi (scalp) EEG sinyalleri analiz edilmiştir. Sonuçlar, apne grubunda derin uyku gücünün istatistiksel olarak anlamlı düzeyde baskılandığını göstermiştir (p < 0,05). Sağlıklı kontrol grubu 0,3409 (Normalize Birim) tepe delta gücü sergilerken; apne grubu 0,2136 seviyesinde kalarak %37,4 oranında daha düşük yoğunluk göstermiştir. Bu bulgular, apnenin beynin homeostatik telafi mekanizmasını devre dışı bırakacak kadar şiddetli olası bir nörofizyolojik baskılanmaya işaret etmektedir.

Anahtar Kelimeler

• obstrüktif uyku apnesi
• delta gücü
• z-score normalizasyonu
• Welch metodu
• uyku bölünmesi

Comparative Analysis Of The Effect Of Obstructive Sleep Apnea (OSA) On Deep Sleep (N3) Delta Power Spectral Density

Öz

Obstructive Sleep Apnea (OSA) is a common disorder characterized by chronic sleep fragmentation and intermittent hypoxia. The aim of this study is to quantitatively compare the Deep Sleep (N3) delta power spectral density (PSD) between healthy individuals and OSA patients. In the study, a hybrid set was created by combining PhysioNet CAP (Healthy) and UCD Sleep Apnea (Patient) databases to increase statistical power, and single-channel scalp EEG signals recorded from the central region (C4/C3) were analyzed. Results showed that deep sleep power was statistically significantly suppressed in the apnea group (p < 0.05). While the healthy control group exhibited a peak delta power of 0.3409 (Normalized Unit); the apnea group remained at the level of 0.2136, showing a 37.4% lower density. These findings suggest that apnea causes a possible neurophysiological suppression that disables the brain's homeostatic compensation mechanism.

Anahtar Kelimeler

• obstructive sleep apnea
• delta power
• z-score normalization
• Welch method
• sleep fragmentation

Kaynakça

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