Egzersiz, İrisin ve Obezite

Year 2022, , 137 - 152, 20.06.2022

Salih Öner , Yavuz Yasul

https://doi.org/10.31680/gaunjss.1119354

Abstract

Gelişmiş ve gelişmekte olan ülkelerdeki şehir hayatının hareketsiz yaşamı, besinsel ürünlere kolay ulaşabilmeyi ve fas food kültürünü yaygınlaştırdığı görülmektedir. Yeni yaşam tarzı hem halk sağlığını tehdit etmekte hem de sistemik metabolik fonksiyon bozukluklarına kılavuzluk ederek obezite gibi hastalıkların yaygınlaşmasına neden olmaktadır. Bu yönüyle obezite ile birlikte adipoz dokudaki doku disfoksiyonu adipokinlerin salgılanması ve yapımında birçok komplikasyona neden olmakta ve yaşam koşullarındaki kaliteyi bozarak mortalite oranını arttırmaktadır. Dolayısıyla bir kartopu gibi büyüyen bu halk sağlığı problemine engel olmak veya ortadan kaldırmak için bilim insanları yeni bir yön bulma çabası içerisindedir. Bu çaba miyokin ailesinin adipokinlerin etkilerini dengelediği ve bunlara karşı koyabileceği şeklindeki keşif ile bilim insanlarını umutlandırmış olsa da bu yönde güçlü bir yargı ortaya koyabilmek için daha fazla idman yapılması şeklindeki gerçekte karşımızda durmaktadır. Özellikle son zamanlarda kas hücrelerindeki miyokinlerin ve miyokin ailesinin bir üyesi olan irisinin beyaz yağ dokusunu esmerleştirmesi, enerji harcanması, glukoz toleransındaki rolü, metabolik işlerle bağlantısı ve vücut kompozisyonu arasındaki ilişkinin keşfi bu yönde çalışan bilim insanlarını heyecanlandırmış ve egzersizin hem irisin hem de obezite üzerinde etkisine yeni bir pencere açmıştır. Bu kapsamda egzersizin insanlar üzerindeki etkilerini anlamaya çalışan bilim insanları egzersiz ve irisin arasındaki ilişkinin yönü hakkında titrek bir ses tonuyla konuşurken egzersiz, irisin ve obezite arasındaki ilişki konusunda daha açık ve anlaşılır bir ifade bütünlüğü görmekteyiz. Dolayısıyla bu derleme egzersiz ile irisin arasındaki ilişkiyi güncel çalışmalara göre değerlendirmek ve egzersiz, irisin ve obezite etkileşimine yeni bir bakış açısı sunmayı amaçlamaktadır.

Keywords

Egzersiz, İrisin, Obezite, Lipit Metabolizması, FNDC5

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