Elit Türk Sporcularında Anjiotensin Dönüştürücü Enzim (I / D) Polimorfizmi ile Sportif Performans Arasındaki İlişkinin İncelenmesi

Year 2018, , 122 - 137, 28.12.2018

Melahat Kurtuluş , Mehmet Günay , Ebru Çetin , Çağrı Çelenk , İbrahim Cicioğlu , Ebru Alp Meral Yirmibeş Karaoğuz Tahsin Kesici

https://doi.org/10.31680/gaunjss.476196

Cited By: 2

Abstract

Anjiotensin dönüştürücü
enzim fiziksel aktivite ile ilişkili önemli bir gendir. ACE geni intron 16’da
plazma ve dokularda ACE düzeylerini belirleyen bir polimorfizme (I/D) sahiptir.
Bu çalışmanın amacı elit Türk sporcularından  (dayanıklılık ve kuvvet sporcusu) oluşan bir
populasyonda (kayak, hentbol, voleybol, güreş) ACE geni I/D polimorfizmi ile
spor performansı arasında bir ilişki olup olmadığını belirlemektir. Periferal
kandan DNA elde edildi ve her bir bireyin ACE genotip dağılımı polimeraz zincir
reaksiyonu yöntemiyle belirlendi. 114 elit Türk sporcusu dayanıklılık (18) ve
kuvvet sporcuları (96) olarak iki gruba ayrıldı. Sporcuların ACE geni genotip
ve alel frekansları; 114 elit sporcu, her bir sporcu grubu,  dayanıklılık sporcuları ve kuvvet sporcuları
olmak üzere dört ayrı katagoride kontrol grubu ile karşılaştırıldı. Ayrıca her
bir spor grubundaki sporcular ile dayanıklılık ve kuvvet sporcuları birbirleriyle
Ki-kare and Fisher exact testi ile karşılaştırıldı. Elit Türk sporcu ve
kontrol grubu arasında ve diğer kategoriler arasında yapılan karşılaştırmalarda
ACE geni genotip dağılımı ve alel frekanslarında istatistiksel olarak anlamlı
bir fark tespit edilmedi (p > 0.05).

Keywords

Anjiotensin Konverting Enzim, Sporcu, Polimorfizm

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