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Dental kök hücrelerin rejeneratif medikal tedavideki yeri

Year 2015, , 98 - 105, 21.04.2015

Özlem Özer Yücel Sibel Gültekin

https://doi.org/10.17214/aot.10464

Abstract

Kök hücreler birçok farklı hücre tipine farklılaşabilme potansiyeline sahip, sınırsız bölünebilme ve yenilenebilme kapasitesi olan hücrelerdir. Kök hücre bazlı tedaviler ve doku mühendisliği, nörodejeneratif hastalıklar, kalp hastalıkları, diabet, ve kanser dahil birçok hastalığın tedavi edilebilmesi için umut vaad etmektedir. Oral bölgeden izole edilen dental kök hücrelerin kemik iliği stroma hücreleri gibi diğer kök hücre kaynaklarına göre daha az invaziv yöntemlerle elde edilebildikleri ve benzer farklılaşma yetenekleri olduğu gösterilmiştir. Bu derleme, kök hücrelerin biyolojik özelliklerini, farklı kök hücre tiplerini, farklılaşma potansiyellerini ve kök hücre kaynaklı rejeneratif medikal tedavi ve doku mühendisliğindeki güncel gelişmeleri özetlemektedir.

Keywords

Kök hücre doku mühendisliği rejeneratif tıp

References

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Dental stem cells in regenerative medicine

Year 2015, , 98 - 105, 21.04.2015

Özlem Özer Yücel Sibel Gültekin

https://doi.org/10.17214/aot.10464

Abstract

Stem cells have remarkable potential to develop into many different cell types with unlimited dividing and self-renewal capacity. Stem cell-based therapies and tissue engineering are considered to be promising for treatment of many diseases including neurodegenerative diseases, heart diseases, diabetes, cancer, etc. Dental stem cells isolated from the oral niches are reported to have similar differentiation capabilities and less invasive isolation methods compared to other stem cells like bone-marrow stem cells. This review outlines the biological properties and different types of stem cells; differentiation potentials and the recent progress of stem cells used in regenerative medicine and tissue engineering.

Keywords

Stem cell tissue engineering regenerative medicine

References

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  • Regenerative medicine glossary. Regen Med 2009;4:S1-88.
  • Asano T, Sasaki K, Kitano Y, Terao K, Hanazono Y. In vivo tumor formation from primate embryonic stem cells. Methods Mol Biol 2006;329:459-67.
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
  • Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
  • Do JT, Schöler HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 2004;22:941-9.
  • Pralong D, Trounson AO, Verma PJ. Cell fusion for reprogramming pluripotency: toward elimination of the pluripotent genome. Stem Cell Rev 2006;2:331-40.
  • Pralong D, Verma PJ. Techniques for nuclear transfer to mouse embryonic stem cells. Methods Mol Biol 2006;348:269-84.
  • Ho PJ, Yen ML, Lin JD, Chen LS, Hu HI, Yeh CK, et al. Endogenous KLF4 expression in human fetal endothelial cells allows for reprogramming to pluripotency with just OCT3/4 and SOX2--brief report. Arterioscler Thromb Vasc Biol 2010;30:1905-7.
  • Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2:3081-9.
  • Kaufman MH, Robertson EJ, Handyside AH, Evans MJ. Establishment of pluripotential cell lines from haploid mouse embryos. J Embryol Exp Morphol 1983;73:249-61.
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS,Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
  • Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, et al. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 2004;350:1353-6.
  • Thomson JA, Marshall VS, Trojanowski JQ. Neural differentiation of rhesus embryonic stem cells. APMIS 1998;106:149-56.
  • Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008;9:11-21.
  • Ho PJ, Yen ML, Yet SF, Yen BL. Current applications of human pluripotent stem cells: Possibilities and challenges. Cell Transplant 2012;21:801-14.
  • Colter DC, Sekiya I, Prockop DJ. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci U S A 2001;98:7841-5.
  • Yamagiwa H, Endo N, Tokunaga K, Hayami T, Hatano H, Takahashi HE. In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2. J Bone Miner Metab 2001;19:20-8.
  • Palmer TD, Ray J, Gage FH. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci 1995;6:474-86.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-30.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. Shed: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807-12.
  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • Coura GS, Garcez RC, de Aguiar CB, Alvarez-Silva M, Magini RS, Trentin AG. Human periodontal ligament: a niche of neural crest stem cells. J Periodontal Res 2008;43:531-6.
  • Morsczeck C, Moehl C, Götz W, Heredia A, Schäffer TE, Eckstein N, et al. In vitro differentiation of human dental follicle cells with dexamethasone and insulin. Cell Biol Int 2005;29:567-75.
  • Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I,Webster AR, et al. A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet 2008;45:155-60.
  • Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 2008;26:1065-73.
  • Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 2005;24:155-65.
  • Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, et al. Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype. Exp Biol Med (Maywood) 2010;235:522-30.
  • Xu C, Police S, Hassanipour M, Li Y, Chen Y, Priest C, et al. Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells. Regen Med 2011;6:53-66.
  • Noguchi H. Production of pancreatic beta-cells from stem cells. Curr Diabetes Rev 2010;6:184-90.
  • Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: Accomplishments to date and future promise. Ther Deliv 2010;1:693-705.
  • Baddour JA, Sousounis K, Tsonis PA. Organ repair and regeneration: an overview. Birth Defects Res C Embryo Today 2012;96:1-29.
  • Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, et al. Myoblast transplantation for heart failure. Lancet 2001;357:279-80.
  • Bai H, Wang ZZ. Directing human embryonic stem cells to generate vascular progenitor cells. Gene Ther 2008;15:89-95.
  • Hill KL, Obrtlikova P, Alvarez DF, King JA, Keirstead SA, Allred JR, et al. Human embryonic stem cell-derived vascular progenitor cells capable
  • of endothelial and smooth muscle cell function. Exp Hematol 2010;38:246-57.
  • Levenberg S, Ferreira LS, Chen-Konak L, Kraehenbuehl TP, Langer R. Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells. Nat Protoc 2010;5:1115-26.
  • Xu XQ, Graichen R, Soo SY, Balakrishnan T, Rahmat SN, Sieh S, et al. Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation 2008;76:958-70.
  • Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, et al. Cd44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 2004;103:2981-9.
  • Ben-Hur T. Human embryonic stem cells for neuronal repair. Isr Med Assoc J 2006;8:122-6.
  • Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in parkinsonian rats. Stem Cells 2004;22:1246-55.
  • Shin S, Mitalipova M, Noggle S, Tibbitts D, Venable A, Rao R, et al. Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions. Stem Cells 2006;24:125-38.
  • Hu BY, Du ZW, Zhang SC. Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc 2009;4:1614-22.
  • Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, et al. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci USA 2009;106:7613-8.
  • Bissonnette CJ, Lyass L, Bhattacharyya BJ, Belmadani A, Miller RJ, Kessler JA. The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells 2011;29:802-11.
  • Lee H, Shamy GA, Elkabetz Y, Schofield CM, Harrsion NL, Panagiotakos G, et al. Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 2007;25:1931-9.
  • Strauss S. Geron trial resumes, but standards for stem cell trials remain elusive. Nat Biotechnol 2010;28:989-90.
  • Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol 2005;23:857-61.
  • Sahu S, Tosh D, Hardikar AA. New sources of beta-cells for treating diabetes. J Endocrinol 2009;202:13-6.
  • Champeris Tsaniras S, Jones PM. Generating pancreatic beta-cells from embryonic stem cells by manipulating signaling pathways. J Endocrinol 2010;206:13-26.
  • Hansen JA, Beatty PG, Anasetti C, Martin PJ, Mickelson E, Thomas ED. Transplantation of hematopoietic stem cells (HSC). Br Med Bull 1987;43:203-16.
  • Bhatia M. Hematopoietic development from human embryonic stem cells. Hematology Am Soc Hematol Educ Program 2007:11-6.
  • Bhatia M. Hematopoiesis from human embryonic stem cells. Ann N Y Acad Sci 2007;1106:219-22.
  • Tucker A, Sharpe P. The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 2004;5:499-508.
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There are 86 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review Article
Authors

Özlem Özer Yücel This is me

Sibel Gültekin This is me

Publication Date April 21, 2015
Published in Issue Year 2015

Cite

APA Özer Yücel, Ö., & Gültekin, S. (2015). Dental kök hücrelerin rejeneratif medikal tedavideki yeri. Acta Odontologica Turcica, 32(2), 98-105. https://doi.org/10.17214/aot.10464
AMA Özer Yücel Ö, Gültekin S. Dental kök hücrelerin rejeneratif medikal tedavideki yeri. Acta Odontol Turc. April 2015;32(2):98-105. doi:10.17214/aot.10464
Chicago Özer Yücel, Özlem, and Sibel Gültekin. “Dental kök hücrelerin Rejeneratif Medikal Tedavideki Yeri”. Acta Odontologica Turcica 32, no. 2 (April 2015): 98-105. https://doi.org/10.17214/aot.10464.
EndNote Özer Yücel Ö, Gültekin S (April 1, 2015) Dental kök hücrelerin rejeneratif medikal tedavideki yeri. Acta Odontologica Turcica 32 2 98–105.
IEEE Ö. Özer Yücel and S. Gültekin, “Dental kök hücrelerin rejeneratif medikal tedavideki yeri”, Acta Odontol Turc, vol. 32, no. 2, pp. 98–105, 2015, doi: 10.17214/aot.10464.
ISNAD Özer Yücel, Özlem - Gültekin, Sibel. “Dental kök hücrelerin Rejeneratif Medikal Tedavideki Yeri”. Acta Odontologica Turcica 32/2 (April 2015), 98-105. https://doi.org/10.17214/aot.10464.
JAMA Özer Yücel Ö, Gültekin S. Dental kök hücrelerin rejeneratif medikal tedavideki yeri. Acta Odontol Turc. 2015;32:98–105.
MLA Özer Yücel, Özlem and Sibel Gültekin. “Dental kök hücrelerin Rejeneratif Medikal Tedavideki Yeri”. Acta Odontologica Turcica, vol. 32, no. 2, 2015, pp. 98-105, doi:10.17214/aot.10464.
Vancouver Özer Yücel Ö, Gültekin S. Dental kök hücrelerin rejeneratif medikal tedavideki yeri. Acta Odontol Turc. 2015;32(2):98-105.