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Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi

Year 2019, Volume: 36 Issue: 2, 53 - 58, 01.05.2019
https://doi.org/10.17214/gaziaot.481136

Abstract

Amaç: Periodontal hastalıklar
mikrobiyal dental plaktaki bakterilerin neden olduğu kronik bir enfeksiyondur.
Periodontopatojen bakteriler hem neden oldukları enflamasyon hem de bakteriyel ürünlerin immün yanıtta oluşturduğu
değişikliklerle psoriazis hastalığının seyrini ve şiddetini etkileyebilir. Bu
çalışmada psoriazis teşhisi konulmuş olan bireylerle, sistemik olarak sağlıklı
bireyler arasındaki periodontal durumun karşılaştırılması amaçlandı.

Gereç ve Yöntem: Bu çalışmaya psoriazis tedavisi devam eden
65 birey (test grubu; 29 kadın, 36 erkek) ve sistemik olarak sağlıklı 100 birey
(kontrol grubu; 52 kadın, 48
erkek) dahil edildi. Hastaların klinik ve
radyolojik periodontal değerlendirmesi yapıldı. Hastalar periodontal
durumlarına göre gingivitis, Stage 1 periodontitis ve Stage 2 periodontitis
olarak alt gruplara ayrıldı. Psoriazisli bireylerin dermatolojik
değerlendirilmesi Psoriazis Alan ve Şiddet İndeksi (PAŞİ) kullanılarak yapıldı.
Elde edilen veriler p<0.05 anlamlılık düzeylerine göre istatistiksel olarak
analiz edildi.

Bulgular: Demografik verilerin değerlendirmesi, gruplar arasında
benzer yaş, cinsiyet, medeni durum ve eğitim durumu seviyeleri olduğunu
gösterdi (p>0.05). Fırçalama sıklığı, oral hijyen seviyesi ve sosyoekonomik
durum kontrol grubunda daha yüksek bulundu (p<0.05). Periodontal klinik
parametreler değerlendirildiğinde test grubunda sondalama cep derinliği (SCD)
ve plak indeksi (Pİ) seviyelerinin daha yüksek olduğu görüldü(p<0.05).
Psoriazisli bireylerde PAŞİ seviyeleri ile periodontal klinik parametreler
arası ilişki incelendiğinde ise Pİ, Gİ ve SKİ seviyeleri, PAŞİ değerleri 0-5,
5-10 ve >10 olan bireylerde benzer bulundu (p>0.05). SCD seviyeleri
açısından psoriazisli hastaların PASI alt grupları arasında anlamlı farklılık
gözlendi(p<0.05).

Sonuç: Psoriazis
hastalarının, sistemik sağlıklı bireylere göre, ağız hijyeni seviyelerinin ve
periodontal durumlarının daha kötü olduğu görülmektedir. Çalışmamızın sonuçları
dahilinde psoriazis ile periodontal hastalık arasında pozitif bir ilişki olduğu
söylenebilir.

References

  • Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol 2006;77:1289-303.
  • Hart TC, Atkinson JC. Mendelian forms of periodontitis. Periodontol 2000 2007;45:95-112.
  • Christophers E. Psoriasis− epidemiology and clinical spectrum. Clin Exp Dermatol 2001;26:314-20.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC: Dermatology. 2nd ed. Berlin: Springer-Verlag, 2000. p. 585-607.
  • Nakib S, Han J, Li T, Joshipura K, Qureshi AA. Periodontal disease and risk of psoriasis among nurses in the United States. Acta Odontol Scand 2013;71:1423-9.
  • Keller J, Lin HC. The effects of chronic periodontitis and its treatment on the subsequent risk of psoriasis. Br J Dermatol 2012;167:1338-44.
  • Fadel HT, Flytström I, Calander AM, Bergbrant IM, Heijl L, Birkhed D. Profiles of dental caries and periodontal disease in individuals with or without psoriasis. J Periodontol 2013;84:477-85.
  • Preus HR, Khanifam P, Kolltveit K, Mørk C, Gjermo P. Periodontitis in psoriasis patients. A blinded, case-controlled study. Acta Odontol Scand 2010;68:165-70.
  • Mahanonda R, Pichyangkul S. Toll‐like receptors and their role in periodontal health and disease. Periodontol 2000 2007;43:41-55.
  • Candia L, Marquez J, Hernandez C, Zea AH, Espinoza LR. Toll-like receptor-2 expression is upregulated in antigen-presenting cells from patients with psoriatic arthritis: a pathogenic role for innate immunity? J Rheumatol 2007;34:374-9.
  • Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 2006;33:401-7.
  • Sharma A, Raman A, Pradeep A. Association of chronic periodontitis and psoriasis: periodontal status with severity of psoriasis. Oral Dis 2015;21:314-9.
  • Skudutyte-Rysstad R, Slevolden EM, Hansen BF, Sandvik L, Preus HR. Association between moderate to severe psoriasis and periodontitis in a Scandinavian population. BMC Oral health 2014;14:139.
  • Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-6.
  • Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-35.
  • Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions–Introduction and key changes from the 1999 classification. J Periodontol 2018;89:1-8.
  • Greene JG, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc 1964;68: 7-13.
  • Cohen AD, Van‐Dijk D, Naggan L, Vardy DA. Effectiveness of climatotherapy at the Dead Sea for psoriasis vulgaris: A community‐oriented study introducing the ‘Beer Sheva Psoriasis Severity Score’. J Dermatolog Treat 2005;16:308-13.
  • Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A, et al. Definition of treatment goals for moderate to severe psoriasis: a European consensus. Arch Dermatol Res 2011;303:1-10.
  • Sarac G, Kapicioglu Y, Cayli S, Altas A, Yologlu S. Is the periodontal status a risk factor for the development of psoriasis? Niger J Clin Pract 2017;20:474-8.
  • Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007;445:866.
  • Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000 1994;5:112-41.
  • Nograles KE, Zaba LC, Shemer A, Fuentes-Duculan J, Cardinale I, Kikuchi T, et al. IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells. J Allergy Clin Immunol 2009;123:1244-52.
  • Davidovici BB, Sattar N, Prinz J, Puig L, Emery P, Barker JN, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol 2010;130:1785-96.
  • Gyurko R, Shoji H, Battaglino R, Boustany G, Gibson FC 3rd, Genco CA, et al. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone 2005;36:472-9.
  • Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells. Nat Immunol 2007;8:950.
  • Rácz E, Prens EP. Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy. Expert Rev Mol Med 2009;14:11.
  • Herrera BS, Martins-Porto R, Campi P, Holzhausen M, Teixeira SA, Mendes GD, et al. Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats. Arch Oral Biol 2011;56:41-7.
  • Levine D, Gottlieb A. Evaluation and management of psoriasis: an internist's guide. Med Clin North Am 2009;93:1291-303.
  • Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008;28:454-67.
  • Rahul K, Pradeep AR. Chronic plaque psoriasis and plaque-induced chronic periodontitis; is there any association: A cross-sectional study. J Periodontol Implant Dent 2011;3:13-20.
  • Lazaridou E, Tsikrikoni A, Fotiadou C, Kyrmanidou E, Vakirlis E, Giannopoulou C, et al. Association of chronic plaque psoriasis and severe periodontitis: a hospital based case‐control study. J Eur Acad Dermatol Venereol 2013;27:967-72.

Evaluation of the association between psoriasis and periodontal status

Year 2019, Volume: 36 Issue: 2, 53 - 58, 01.05.2019
https://doi.org/10.17214/gaziaot.481136

Abstract

Objective: Periodontal disease
is a chronic infection induced by bacteria of the microbial dental plaque.
Periodontopathogenic bacteria can affect the formation and severity of
psoriasis by both the inflammation they cause and the altered immune response
by their products. The aim of this study was to compare the periodontal status
between psoriasis-diagnosed individuals and systemically healthy individuals.



Materials and Method:
Sixty-five
patients undergoing psoriasis treatment (test group; 29 females, 36 males) and
100 systemic healthy individuals (control group; 52 females, 48 males) were
included in the present study. Clinical and radiographic periodontal
assessments were performed. The patients were divided into subgroups according
to their periodontal status as gingivitis, Stage 1 and Stage 2 periodontitis.
The dermatological evaluation of the psoriasis patients was performed using the
Psoriasis Area and Severity Index (PASI). The data were statistically analyzed
considering
p<0.05 as significant.



Results: The demographic data
presented similar age, gender, marital status, and educational status among the
groups (p>0.05). Tooth brushing frequency, oral hygiene levels, and
socioeconomic status were found higher in the control group (p<0.05). When
periodontal clinical parameters were evaluated, probing pocket depth (PPD) and
plaque index (PI) were found higher in the test group (p<0.05). Likewise,
when the relationship between PASI levels and periodontal clinical parameters
were examined in psoriasis patients, PI, GI, and BOP levels were found similar
in the patients with 0-5, 5-10 and >10 PASI values (p>0.05). Significant
PPD level differences were detected among the PASI subgroups of the psoriasis
patients (p<0.05).



Conclusion: Psoriasis patients
appear to have poor oral hygiene and poor periodontal status compared to
systemically healthy individuals. The findings suggest a positive relationship
between periodontal disease and psoriasis.

References

  • Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol 2006;77:1289-303.
  • Hart TC, Atkinson JC. Mendelian forms of periodontitis. Periodontol 2000 2007;45:95-112.
  • Christophers E. Psoriasis− epidemiology and clinical spectrum. Clin Exp Dermatol 2001;26:314-20.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC: Dermatology. 2nd ed. Berlin: Springer-Verlag, 2000. p. 585-607.
  • Nakib S, Han J, Li T, Joshipura K, Qureshi AA. Periodontal disease and risk of psoriasis among nurses in the United States. Acta Odontol Scand 2013;71:1423-9.
  • Keller J, Lin HC. The effects of chronic periodontitis and its treatment on the subsequent risk of psoriasis. Br J Dermatol 2012;167:1338-44.
  • Fadel HT, Flytström I, Calander AM, Bergbrant IM, Heijl L, Birkhed D. Profiles of dental caries and periodontal disease in individuals with or without psoriasis. J Periodontol 2013;84:477-85.
  • Preus HR, Khanifam P, Kolltveit K, Mørk C, Gjermo P. Periodontitis in psoriasis patients. A blinded, case-controlled study. Acta Odontol Scand 2010;68:165-70.
  • Mahanonda R, Pichyangkul S. Toll‐like receptors and their role in periodontal health and disease. Periodontol 2000 2007;43:41-55.
  • Candia L, Marquez J, Hernandez C, Zea AH, Espinoza LR. Toll-like receptor-2 expression is upregulated in antigen-presenting cells from patients with psoriatic arthritis: a pathogenic role for innate immunity? J Rheumatol 2007;34:374-9.
  • Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 2006;33:401-7.
  • Sharma A, Raman A, Pradeep A. Association of chronic periodontitis and psoriasis: periodontal status with severity of psoriasis. Oral Dis 2015;21:314-9.
  • Skudutyte-Rysstad R, Slevolden EM, Hansen BF, Sandvik L, Preus HR. Association between moderate to severe psoriasis and periodontitis in a Scandinavian population. BMC Oral health 2014;14:139.
  • Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-6.
  • Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-35.
  • Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions–Introduction and key changes from the 1999 classification. J Periodontol 2018;89:1-8.
  • Greene JG, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc 1964;68: 7-13.
  • Cohen AD, Van‐Dijk D, Naggan L, Vardy DA. Effectiveness of climatotherapy at the Dead Sea for psoriasis vulgaris: A community‐oriented study introducing the ‘Beer Sheva Psoriasis Severity Score’. J Dermatolog Treat 2005;16:308-13.
  • Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A, et al. Definition of treatment goals for moderate to severe psoriasis: a European consensus. Arch Dermatol Res 2011;303:1-10.
  • Sarac G, Kapicioglu Y, Cayli S, Altas A, Yologlu S. Is the periodontal status a risk factor for the development of psoriasis? Niger J Clin Pract 2017;20:474-8.
  • Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007;445:866.
  • Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000 1994;5:112-41.
  • Nograles KE, Zaba LC, Shemer A, Fuentes-Duculan J, Cardinale I, Kikuchi T, et al. IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells. J Allergy Clin Immunol 2009;123:1244-52.
  • Davidovici BB, Sattar N, Prinz J, Puig L, Emery P, Barker JN, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol 2010;130:1785-96.
  • Gyurko R, Shoji H, Battaglino R, Boustany G, Gibson FC 3rd, Genco CA, et al. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone 2005;36:472-9.
  • Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells. Nat Immunol 2007;8:950.
  • Rácz E, Prens EP. Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy. Expert Rev Mol Med 2009;14:11.
  • Herrera BS, Martins-Porto R, Campi P, Holzhausen M, Teixeira SA, Mendes GD, et al. Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats. Arch Oral Biol 2011;56:41-7.
  • Levine D, Gottlieb A. Evaluation and management of psoriasis: an internist's guide. Med Clin North Am 2009;93:1291-303.
  • Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008;28:454-67.
  • Rahul K, Pradeep AR. Chronic plaque psoriasis and plaque-induced chronic periodontitis; is there any association: A cross-sectional study. J Periodontol Implant Dent 2011;3:13-20.
  • Lazaridou E, Tsikrikoni A, Fotiadou C, Kyrmanidou E, Vakirlis E, Giannopoulou C, et al. Association of chronic plaque psoriasis and severe periodontitis: a hospital based case‐control study. J Eur Acad Dermatol Venereol 2013;27:967-72.
There are 32 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Original Research Article
Authors

Özge Göktürk

Fatma Uçan Yarkaç 0000-0001-8126-585X

Atiye Oğrum

Publication Date May 1, 2019
Published in Issue Year 2019 Volume: 36 Issue: 2

Cite

APA Göktürk, Ö., Uçan Yarkaç, F., & Oğrum, A. (2019). Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi. Acta Odontologica Turcica, 36(2), 53-58. https://doi.org/10.17214/gaziaot.481136
AMA Göktürk Ö, Uçan Yarkaç F, Oğrum A. Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi. Acta Odontol Turc. May 2019;36(2):53-58. doi:10.17214/gaziaot.481136
Chicago Göktürk, Özge, Fatma Uçan Yarkaç, and Atiye Oğrum. “Psoriazis Ve Periodontal Durum arasındaki ilişkinin değerlendirilmesi”. Acta Odontologica Turcica 36, no. 2 (May 2019): 53-58. https://doi.org/10.17214/gaziaot.481136.
EndNote Göktürk Ö, Uçan Yarkaç F, Oğrum A (May 1, 2019) Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi. Acta Odontologica Turcica 36 2 53–58.
IEEE Ö. Göktürk, F. Uçan Yarkaç, and A. Oğrum, “Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi”, Acta Odontol Turc, vol. 36, no. 2, pp. 53–58, 2019, doi: 10.17214/gaziaot.481136.
ISNAD Göktürk, Özge et al. “Psoriazis Ve Periodontal Durum arasındaki ilişkinin değerlendirilmesi”. Acta Odontologica Turcica 36/2 (May 2019), 53-58. https://doi.org/10.17214/gaziaot.481136.
JAMA Göktürk Ö, Uçan Yarkaç F, Oğrum A. Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi. Acta Odontol Turc. 2019;36:53–58.
MLA Göktürk, Özge et al. “Psoriazis Ve Periodontal Durum arasındaki ilişkinin değerlendirilmesi”. Acta Odontologica Turcica, vol. 36, no. 2, 2019, pp. 53-58, doi:10.17214/gaziaot.481136.
Vancouver Göktürk Ö, Uçan Yarkaç F, Oğrum A. Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi. Acta Odontol Turc. 2019;36(2):53-8.