Peri-implantitiste Tedavi Yönetimi

Year 2023, Volume: 40 Issue: 2, 55 - 60, 02.05.2023

Habibe Akkale , Seher Arseven Tunç , Berrin Ünsal

https://doi.org/10.17214/gaziaot.1210647

Abstract

Dental implantlar, dişsiz bölgelerde diş kökü gibi fonksiyon görmek üzere tasarlanmış biyouyumlu materyallerdir. Dental implant uygulamalarının son yıllarda artmasıyla birlikte implant çevresi hastalıkların görülme olasılığı da artmıştır. Peri-implant hastalık yalnızca mukoza enflamasyonu ile sınırlı kaldığında peri-implant mukozitis olarak adlandırılırken bu duruma peri-implant kemik kaybı da eklendiğinde hastalık peri-implantitis adını alır. Hastalığın etiyolojisinde temelde mikrobiyal biyofilm rol oynar. Bununla birlikte, implantın yüzey özellikleri, pozisyonu, üst yapısı, yetersiz oral hijyen, sigara ve/veya alkol tüketimi, sistemik hastalıklar ve stres gibi risk faktörleri de peri-implant hastalıklarla ilişkilendirilmiştir. Bu derlemede amaç, peri-implantitis tedavisine yönelik cerrahi olan ve olmayan yaklaşımlar ile yapılan tedavilerin etkinliklerini değerlendirmektir.

Keywords

Peri-implantitis, Dental implant, Cerrahi tedavi, Cerrahi olmayan tedavi

Peri-implantitiste Tedavi Yönetimi

Abstract

Dental implants are biocompatible materials designed to function like tooth roots in edentulous areas. With the increase in dental implant applications in recent years, the likelihood of peri-implant diseases has also increased. When peri-implant disease is limited to mucosal inflammation, it is called peri-implant mucositis. When peri-implant bone loss is added to this condition, the disease is called peri-implantitis. Microbial biofilm plays a fundamental role in the etiology of the disease. However, risk factors such as implant surface properties, implant position, superstructure of implant, inadequate oral hygiene, smoking and/or alcohol consumption, systemic diseases and stress have also been associated with peri-implant diseases. The aim of this review is to evaluate the efficacy of therapies with surgical and non-surgical approaches for the treatment of peri-implantitis.

Keywords

Peri-implantitis, Dental implant, Cerrahi tedavi, Cerrahi olmayan tedavi

References

• 1. Kormas I, Pedercini C, Pedercini A, Raptopoulos M, Alassy H, Wolff LF. Peri-implant diseases: diagnosis, clinical, histological, microbiological characteristics and treatment strategies. A narrative review. Antibiotics. 2020;9(11):835.
• 2. Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions–Introduction and key changes from the 1999 classification. In. Vol 89: Wiley Online Library; 2018:S1-S8.
• 3. Schwarz F, Derks J, Monje A, Wang HL. Peri‐implantitis. J Clin Periodontol. 2018;45:S246-S266.
• 4. Diaz P, Gonzalo E, Villagra LJG, Miegimolle B, Suarez MJ. What is the prevalence of peri-implantitis? A systematic review and meta-analysis. BMC Oral Health. 2022;22(1):1-13.
• 5. Cosgarea R, Sculean A, Shibli JA, Salvi GE. Prevalence of peri-implant diseases–a critical review on the current evidence. Braz Oral Res. 2019;33.
• 6. Fragkioudakis I, Tseleki G, Doufexi A-E, Sakellari D. Current concepts on the pathogenesis of peri-implantitis: A narrative review. Eur J Dent. 2021;15(02):379-387.
• 7. Wada M, Mameno T, Otsuki M, Kani M, Tsujioka Y, Ikebe K. Prevalence and risk indicators for peri-implant diseases: A literature review. Jpn Dent Sci Rev. 2021;57:78-84.
• 8. Trindade R, Albrektsson T, Tengvall P, Wennerberg A. Foreign body reaction to biomaterials: on mechanisms for buildup and breakdown of osseointegration. Clin Implant Dent Relat Res. 2016;18(1):192-203.
• 9. Albrektsson T, Canullo L, Cochran D, De Bruyn H. “Peri‐implantitis”: a complication of a foreign body or a man‐made “disease”. Facts and fiction. Clin Implant Dent Relat Res. 2016;18(4):840-849.
• 10. Murray CM, Knight ET, Russell AA, Tawse-Smith A, Leichter JW. Peri-implant disease: current understanding and future direction. NZ Dent J. 2013;109(2):55-62.
• 11. Renvert S, Polyzois I. Treatment of pathologic peri‐implant pockets. Periodontol 2000. 2018;76(1):180-190.
• 12. dos Santos Martins BG, Hasse Fernandes JC, Gomes Martins A, de Moraes Castilho R, de Oliveira Fernandes GV. Surgical and Nonsurgical Treatment Protocols for Peri-implantitis: An Overview of Systematic Reviews. Int J Oral Maxillofac Implants. 2022;37(4).
• 13. Figuero E, Graziani F, Sanz I, Herrera D, Sanz M. Management of peri‐implant mucositis and peri‐implantitis. Periodontol 2000. 2014;66(1):255-273.
• 14. Wilson Jr TG, Valderrama P, Rodrigues DB. Commentary: The Case for Routine Maintenance of Dental Implants. J Periodontol. 2014;85(5):657-660.
• 15. Fox SC, Moriarty JD, Kusy RP. The effects of scaling a titanium implant surface with metal and plastic instruments: an in vitro study. J Periodontol. 1990;61(8):485-490.
• 16. Bertoldi C, Lusuardi D, Battarra F, Sassatelli P, Spinato S, Zaffe D. The maintenance of inserted titanium implants: in‐vitro evaluation of exposed surfaces cleaned with three different instruments. Clin Oral Implants Res. 2017;28(1):57-63.
• 17. Sirinirund B, Garaicoa-Pazmino C, Wang H-L. Effects of Mechanical Instrumentation with Commercially Available Instruments Used in Supportive Peri-implant Therapy: An In Vitro Study. Int J Oral Maxillofac Implants. 2019;34(6).
• 18. Ramaglia L, di Lauro AE, Morgese F, Squillace A. Profilometric and standard error of the mean analysis of rough implant surfaces treated with different instrumentations. Implant Dent. 2006;15(1):77-82.
• 19. Tastepe CS, van Waas R, Liu Y, Wismeijer D. Air powder abrasive treatment as an implant surface cleaning method: a literature review. Int J Oral Maxillofac Implants. 2012;27(6).
• 20. Schwarz F, Becker K, Renvert S. Efficacy of air polishing for the non‐surgical treatment of peri‐implant diseases: a systematic review. J Clin Periodontol. 2015;42(10):951-959.
• 21. Hentenaar DF, De Waal YC, Stewart RE, Van Winkelhoff AJ, Meijer HJ, Raghoebar GM. Erythritol airpolishing in the non‐surgical treatment of peri‐implantitis: A randomized controlled trial. Clin Oral Implants Res. 2021;32(7):840-852.
• 22. Keim D, Nickles K, Dannewitz B, Ratka C, Eickholz P, Petsos H. In vitro efficacy of three different implant surface decontamination methods in three different defect configurations. Clin Oral Implants Res. 2019;30(6):550-558.
• 23. Renvert S, Lindahl C, Roos Jansåker AM, Persson GR. Treatment of peri‐implantitis using an Er: YAG laser or an air‐abrasive device: a randomized clinical trial. J Clin Periodontol. 2011;38(1):65-73.
• 24. Mettraux GR, Sculean A, Bürgin WB, Salvi GE. Two‐year clinical outcomes following non‐surgical mechanical therapy of peri‐implantitis with adjunctive diode laser application. Clin Oral Implants Res. 2016;27(7):845-849.
• 25. Arısan V, Karabuda ZC, Arıcı SV, Topçuoğlu N, Külekçi G. A randomized clinical trial of an adjunct diode laser application for the nonsurgical treatment of peri-implantitis. Photomed Laser Surg. 2015;33(11):547-554.
• 26. Schär D, Ramseier CA, Eick S, Arweiler NB, Sculean A, Salvi GE. Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res. 2013;24(1):104-110.
• 27. Bassetti M, Schär D, Wicki B, et al. Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: 12‐month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res. 2014;25(3):279-287.
• 28. Chambrone L, Wang HL, Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and peri‐implantitis: An American Academy of Periodontology best evidence review. J Periodontol. 2018;89(7):783-803.
• 29. Wang H, Li W, Zhang D, Li W, Wang Z. Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial. Aust Dent J. 2019;64(3):256-262.
• 30. Renvert S, Roos‐Jansåker AM, Claffey N. Non‐surgical treatment of peri‐implant mucositis and peri‐implantitis: a literature review. J Clin Periodontol. 2008;35:305-315.
• 31. Muthukuru M, Zainvi A, Esplugues EO, Flemmig TF. Non‐surgical therapy for the management of peri‐implantitis: a systematic review. Clin Oral Implants Res. 2012;23:77-83.
• 32. Carcuac O, Derks J, Charalampakis G, Abrahamsson I, Wennström J, Berglundh T. Adjunctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: a randomized controlled clinical trial. J Dent Res. 2016;95(1):50-57.
• 33. Machtei EE, Romanos G, Kang P, et al. Repeated delivery of chlorhexidine chips for the treatment of peri‐implantitis: A multicenter, randomized, comparative clinical trial. J Periodontol. 2021;92(1):11-20.
• 34. Romanos GE, Javed F, Delgado-Ruiz RA, Calvo-Guirado JL. Peri-implant diseases: a review of treatment interventions. Dent Clin North Am. 2015;59(1):157-178.
• 35. Verdugo F, Laksmana T, Uribarri A. Systemic antibiotics and the risk of superinfection in peri-implantitis. Arch Oral Biol. 2016;64:39-50.
• 36. Mombelli A, Feloutzis A, Brägger U, Lang NP. Treatment of peri‐implantitis by local delivery of tetracycline: Clinical, microbiological and radiological results. Clin Oral Implants Res. 2001;12(4):287-294.
• 37. Galofré M, Palao D, Vicario M, Nart J, Violant D. Clinical and microbiological evaluation of the effect of Lactobacillus reuteri in the treatment of mucositis and peri‐implantitis: A triple‐blind randomized clinical trial. J Periodontal Res. 2018;53(3):378-390.
• 38. Tada H, Masaki C, Tsuka S, Mukaibo T, Kondo Y, Hosokawa R. The effects of Lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: A randomized placebo-controlled study. J Prosthodont Res. 2018;62(1):89-96.
• 39. Laleman I, Pauwels M, Quirynen M, Teughels W. The usage of a lactobacilli probiotic in the non‐surgical therapy of peri‐implantitis: A randomized pilot study. Clin Oral Implants Res. 2020;31(1):84-92.
• 40. Klinge B, Meyle J, 2 WG. Peri‐implant tissue destruction. The third EAO consensus conference 2012. Clin Oral Implants Res. 2012;23:108-110.
• 41. Renvert S, Polyzois I, Maguire R. Re‐osseointegration on previously contaminated surfaces: a systematic review. Clin Oral Implants Res. 2009;20:216-227.
• 42. Hallström H, Persson GR, Lindgren S, Renvert S. Open flap debridement of peri‐implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. J Clin Periodontol. 2017;44(12):1285-1293.
• 43. Heitz‐Mayfield LJ, Salvi GE, Mombelli A, et al. Supportive peri‐implant therapy following anti‐infective surgical peri‐implantitis treatment: 5‐year survival and success. Clin Oral Implants Res. 2018;29(1):1-6.
• 44. Renvert S, Roos‐Jansåker AM, Persson GR. Surgical treatment of peri‐implantitis lesions with or without the use of a bone substitute—a randomized clinical trial. J Clin Periodontol. 2018;45(10):1266-1274.
• 45. Cha J, Lee J, Kim C. Surgical therapy of peri-implantitis with local minocycline: a 6-month randomized controlled clinical trial. J Dent Res. 2019;98(3):288-295.46. De Waal Y, Raghoebar G, Meijer
• 46. H, Winkel E, Van Winkelhoff A. Implant decontamination with 2% chlorhexidine during surgical peri‐implantitis treatment: a randomized, double‐blind, controlled trial. Clin Oral Implants Res. 2015;26(9):1015-1023.
• 47. Papadopoulos CA, Vouros I, Menexes G, Konstantinidis A. The utilization of a diode laser in the surgical treatment of peri-implantitis. A randomized clinical trial. Clin Oral Investig. 2015;19(8):1851-1860.
• 48. Schwarz F, Schmucker A, Becker J. Efficacy of alternative or adjunctive measures to conventional treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Implant Dent. 2015;1(1):1-34.
• 49. Renvert S, Polyzois IN. Clinical approaches to treat peri‐implant mucositis and peri‐implantitis. Periodontol 2000. 2015;68(1):369-404.
• 50. Keeve PL, Koo KT, Ramanauskaite A, et al. Surgical Treatment of Periimplantitis With Non–Augmentative Techniques. Implant Dent. 2019;28(2):177-186.
• 51. Romeo E, Lops D, Chiapasco M, Ghisolfi M, Vogel G. Therapy of peri‐implantitis with resective surgery. A 3‐year clinical trial on rough screw‐shaped oral implants. Part II: radiographic outcome. Clin Oral Implants Res. 2007;18(2):179-187.
• 52. Ramel CF, Lüssi A, Özcan M, Jung RE, Hämmerle CH, Thoma DS. Surface roughness of dental implants and treatment time using six different implantoplasty procedures. Clin Oral Implants Res. 2016;27(7):776-781.
• 53. Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature‐induced peri‐implantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007;18(2):161-170.
• 54. de Waal YC, Raghoebar GM, Huddleston Slater JJ, Meijer HJ, Winkel EG, van Winkelhoff AJ. Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial. J Clin Periodontol. 2013;40(2):186-195.
• 55. Englezos E, Cosyn J, Koole S, Jacquet W, De Bruyn H. Resective Treatment of Peri-implantitis: Clinical and Radiographic Outcomes After 2 Years. Int J Periodontics Restorative Dent. 2018;38(5).
• 56. Carcuac O, Derks J, Abrahamsson I, Wennström JL, Petzold M, Berglundh T. Surgical treatment of peri‐implantitis: 3‐year results from a randomized controlled clinical trial. J Clin Periodontol. 2017;44(12):1294-1303.
• 57. de Waal YC, Raghoebar GM, Meijer HJ, Winkel EG, van Winkelhoff AJ. Prognostic indicators for surgical peri‐implantitis treatment. Clin Oral Implants Res. 2016;27(12):1485-1491.
• 58. Jepsen S, Schwarz F, Cordaro L, et al. Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol. 2019;46:277-286.
• 59. Tomasi C, Regidor E, Ortiz‐Vigón A, Derks J. Efficacy of reconstructive surgical therapy at peri‐implantitis‐related bone defects. A systematic review and meta‐analysis. J Clin Periodontol. 2019;46:340-356.
• 60. Froum SJ, Froum SH, Rosen PS. A Regenerative Approach to the Successful Treatment of Peri-implantitis: A Consecutive Series of 170 Implants in 100 Patients with 2-to 10-Year Follow-up. Int J Periodontics Restorative Dent. 2015;35(6).
• 61. Romanos GE, Nentwig GH. Regenerative Therapy of Deep Peri-implant Infrabony Defects After CO 2 Laser Implant Surface Decontamination. Int J Periodontics Restorative Dent. 2008;28(3).
• 62. Isler SC, Unsal B, Soysal F, Ozcan G, Peker E, Karaca IR. The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis. J Periodontal Implant Sci. 2018;48(3):136-151.
• 63. Schwarz F, Jepsen S, Obreja K, Galarraga‐Vinueza ME, Ramanauskaite A. Surgical therapy of peri‐implantitis. Periodontol 2000. 2022;88(1):145-181.
• 64. Aghazadeh A, Rutger Persson G, Renvert S. A single‐centre randomized controlled clinical trial on the adjunct treatment of intra‐bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol. 2012;39(7):666-673.
• 65. Guler B, Uraz A, Yalım M, Bozkaya S. The comparison of porous titanium granule and xenograft in the surgical treatment of peri‐implantitis: A prospective clinical study. Clin Implant Dent Relat Res. 2017;19(2):316-327.
• 66. Schwarz F, Sahm N, Schwarz K, Becker J. Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri‐implantitis. J Clin Periodontol. 2010;37(5):449-455.
• 67. de Tapia B, Valles C, Ribeiro-Amaral T, et al. The adjunctive effect of a titanium brush in implant surface decontamination at peri‐implantitis surgical regenerative interventions: A randomized controlled clinical trial. J Clin Periodontol. 2019;46(5):586-596.
• 68. Schwarz F, John G, Becker J. Reentry after combined surgical resective and regenerative therapy of advanced peri-implantitis: a retrospective analysis of five cases. Int J Periodontics Restorative Dent. 2015;35(5):647-653.
• 69. Nart J, de Tapia B, Pujol À, Pascual A, Valles C. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: a 1-year follow-up case series. Clin Oral Investig. 2018;22(6):2199-2207.
• 70. Ramanauskaite A, Becker K, Juodzbalys G, Schwarz F. Clinical outcomes following surgical treatment of peri-implantitis at grafted and non-grafted implant sites: a retrospective analysis. Int J Implant Dent. 2018;4(1):1-8.