[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi

Yıl 2017, , 0 - 0, 13.06.2017

Nuray Yıldız , Deniz Kıvrakdal Özkul

https://doi.org/10.17341/gazimmfd.322186

Öz

 

 

Bu çalışmada, F¹⁸[FDG] sentezi için gerekli olan olan ¹⁸F üretiminde kullanılmış  [¹⁸O]H₂O’deki, organik safsızlıkların giderilmesi için ozonlama, ultrasonikasyon ve damıtma yöntemleri ayrı ayrı ve birleştirilmiş olarak örneklere uygulanmıştır.

Organik safsızlıkların giderilmesi için belirlenen yöntemler ilk olarak hazırlanan model çözeltilere uygulanmıştır. Sonuçlar  ozon+ultrasonikasyon yönteminin ışınlanmış [¹⁸O]H₂O’i saflaştırmak için en uygun yöntem olduğunu göstermiştir. Bu yöntemle saflaştırılan [¹⁸O]H₂O ile [¹⁸F]flor ve [¹⁸F]FDG üretimi yapılmış, saflaştırılmış [¹⁸O]H₂O ile % 69 verim elde edilirken, yeni [¹⁸O]H₂O ile % 72 verim elde edilmiştir. Elde edilen sonuçlar ışınlanmış [¹⁸O]H₂O içindeki safsızlıklar giderilerek, kliniklerde  tekrar kullanılabileceğini göstermiştir.

Anahtar Kelimeler

[18O]H2O, [18 F] Flor, siklotron, ultrasonikasyon, ozonlama

Kaynakça

• Moon, W., Oh, S., Cheon, J. ve Chae, W., “Simple purification of recovered [18O]H2O by UV, ozone and solid-phase extraction methods”, Applied Radiation and Isotopes , Cilt 65, No 6, 635-40, 2007.
• Fawdry, R. M., “A simple effective method for estimating the [18O] enrichment of water mixtures”, Applied Radiation and Isotopes Cilt 60, 23-26, 2004.
• Kitano, H., Magata, Y., Tanaka, A. ve Mukaı, T,. “ Performance assessment of O-18 water purifier”, Annals of Nuclear Medicine, Cilt 15, No.1, 75-78, 2001
• Nishijima, K., Kugea, Y., Tsukamotob, E. ve Sekic, K., “Increased [18F]2-fluoro- deoxy-d-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield”, Applied Radiation and Isotopes Cilt 57, 43-39, 2002.
• Ito, S., Sakane, H., Deji, S. Ve Saze, T.,” Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesi”, Applied Radiation and Isotopes Cilt 64, 298- 305, 2006.
• Huang, B., Channing, M., Plascjak, P. ve Kiesewetter, D.,” Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography”, Nuclear Medicine and Biology, Cilt 30, 785-790, 2003.
• Asti, M., Grassi, E., Sghedoni, R. ve De Pietri, G. . “Purification by ozonolysis of
• O enriched water after cyclotron ırradiation and the utilization of the purified
• water for the purification [18F]FDG” Applied Radiation and Isotopes, 65, 831-835,
• Twenson, T.J., Berridge, M.S., Bolomey, L., vd.,. “Routine production of reactive flüorine-18 flouride salts from an oxygen-18 water target”, Nuclear Medicine and Biology Cilt 15, 499-504, 1988.
• Berridge, M.S. ve Kjellström, R., “ Design and use of silver targets for [18F]flouride production”, Applied Radiation and Isotopes, Cilt 50, 699-705, 1999.
• Weber, K., Marx, H., Vierling, J., Wittstadt, U. ve Eisenhut, M., “Electrolytic purification of [18O ] water. J. Labeled”, Compounds Radio-Pharmaceuticals, Cilt 46 (Suppl. 1) S279, 2003.
• Mangner, T.J., Mulholland, G.K., Toorongian, S.A., Jewett, D.M. ve Kilbourn, M.R., “Purification of used O-18 target water by photochemical combustion”, Journal of Nuclear Medicine, Cilt 33, 982–983, 1992.
• Armstrong, F.A., Williams, P.M. and Strickland, D.H.,” Photo-oxidation of organic matter in seawater by ultra-violet radiation, analytical and other applications”, Nature 211, 481-484. 1966.
• Hernandez, R., Zappi, M., Colucci J. ve Jones, R., “ Comparing the performance of various advanced oxidation processes for treatment of acetone contaminated water”, Journal of Hazardous Materials, Cilt 92, 33–50, 2002
• Park, H.S., Hwang, T.M., Kang, J.W., Choi, H., ve Oh, H.J., 2001.” Characterization of raw water for the ozone application measuring ozone consumption rate”. Water Research, Cilt 11, 2607–2614, 2001.
• Goel, M., Hongqiang, H., Mujumdar, A.S. ve Ray M.B. ,”Sonochemical
• decomposition of volatile and non-volatile organic compounds—a comparative
• study”, Water Research, Cilt 38, 4247–4261, 2004.
• Jyothi, K.P. Suguna Yesodharan, Yesodharan E.P., “Ultrasound (US), Ultraviolet light (UV) and combination (US + UV) assisted semiconductor catalysed degradation of organic pollutants in water: Oscillation in the concentration of hydrogen peroxide formed in situ”, Ultrasonic Sonochemistry, Cilt 21, 1787-1796, 2014.
• Mahammuni, N.N. ve Adewuyi Y.G., “Advanced oxidation processes (AOPs) involving ultrasound for waste water treatment: A review with emphasis on cost estimation”, Ultrasonic Sonochemistry Cilt 17, 990-1003, 2010.
• Beckett, M.A. ve Hua, I.,”Impact of Ultrasonic Frequency on Aqueous
• Sonoluminescence and Sonochemistry”. J. Phys. Chem. A., Cilt 105, No 15, 3796-3802, 2001.
• Schwarz, S.W., McCarthy, T.J., King, N., vd.” FDG PETtrace MicroLab: average [18F]FDG E.O.S. activity compared to the source of the [18O]water used” Proceedings of the Seventh Workshop on Targetry and Target Chemistry, pp. 246–247, 1997.
• Masten, S.J. ve Davies, H.R.,” The use of ozonization to degrade organic contaminants in wastewaters”, Environmental Science and Technology, Cilt 28, No
• , 180-185, 1994.
• Naffrechoux, E., Chanoux, S., Petrier, C. ve Suptil, J.,” Sonochemical and photochemical oxidation of organic matter”, Ultrasonics Sonochemistry, Cilt 7,
• –259, 2000.