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[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi

Year 2017, Volume: 32 Issue: 2, 0 - 0, 13.06.2017

Nuray Yıldız Deniz Kıvrakdal Özkul

https://doi.org/10.17341/gazimmfd.322186

Abstract

 

 

Bu çalışmada, F18[FDG] sentezi için gerekli olan olan 18F üretiminde kullanılmış  [18O]H2O’deki, organik safsızlıkların giderilmesi için ozonlama, ultrasonikasyon ve damıtma yöntemleri ayrı ayrı ve birleştirilmiş olarak örneklere uygulanmıştır.

Organik safsızlıkların giderilmesi için belirlenen yöntemler ilk olarak hazırlanan model çözeltilere uygulanmıştır. Sonuçlar  ozon+ultrasonikasyon yönteminin ışınlanmış [18O]H2O’i saflaştırmak için en uygun yöntem olduğunu göstermiştir. Bu yöntemle saflaştırılan [18O]H2O ile [18F]flor ve [18F]FDG üretimi yapılmış, saflaştırılmış [18O]H2O ile % 69 verim elde edilirken, yeni [18O]H2O ile % 72 verim elde edilmiştir. Elde edilen sonuçlar ışınlanmış [18O]H2O içindeki safsızlıklar giderilerek, kliniklerde  tekrar kullanılabileceğini göstermiştir.

Keywords

[18O]H2O [18 F] Flor siklotron ultrasonikasyon ozonlama

References

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  • Ito, S., Sakane, H., Deji, S. Ve Saze, T.,” Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesi”, Applied Radiation and Isotopes Cilt 64, 298- 305, 2006.
  • Huang, B., Channing, M., Plascjak, P. ve Kiesewetter, D.,” Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography”, Nuclear Medicine and Biology, Cilt 30, 785-790, 2003.
  • Asti, M., Grassi, E., Sghedoni, R. ve De Pietri, G. . “Purification by ozonolysis of
  • O enriched water after cyclotron ırradiation and the utilization of the purified
  • water for the purification [18F]FDG” Applied Radiation and Isotopes, 65, 831-835,
  • Twenson, T.J., Berridge, M.S., Bolomey, L., vd.,. “Routine production of reactive flüorine-18 flouride salts from an oxygen-18 water target”, Nuclear Medicine and Biology Cilt 15, 499-504, 1988.
  • Berridge, M.S. ve Kjellström, R., “ Design and use of silver targets for [18F]flouride production”, Applied Radiation and Isotopes, Cilt 50, 699-705, 1999.
  • Weber, K., Marx, H., Vierling, J., Wittstadt, U. ve Eisenhut, M., “Electrolytic purification of [18O ] water. J. Labeled”, Compounds Radio-Pharmaceuticals, Cilt 46 (Suppl. 1) S279, 2003.
  • Mangner, T.J., Mulholland, G.K., Toorongian, S.A., Jewett, D.M. ve Kilbourn, M.R., “Purification of used O-18 target water by photochemical combustion”, Journal of Nuclear Medicine, Cilt 33, 982–983, 1992.
  • Armstrong, F.A., Williams, P.M. and Strickland, D.H.,” Photo-oxidation of organic matter in seawater by ultra-violet radiation, analytical and other applications”, Nature 211, 481-484. 1966.
  • Hernandez, R., Zappi, M., Colucci J. ve Jones, R., “ Comparing the performance of various advanced oxidation processes for treatment of acetone contaminated water”, Journal of Hazardous Materials, Cilt 92, 33–50, 2002
  • Park, H.S., Hwang, T.M., Kang, J.W., Choi, H., ve Oh, H.J., 2001.” Characterization of raw water for the ozone application measuring ozone consumption rate”. Water Research, Cilt 11, 2607–2614, 2001.
  • Goel, M., Hongqiang, H., Mujumdar, A.S. ve Ray M.B. ,”Sonochemical
  • decomposition of volatile and non-volatile organic compounds—a comparative
  • study”, Water Research, Cilt 38, 4247–4261, 2004.
  • Jyothi, K.P. Suguna Yesodharan, Yesodharan E.P., “Ultrasound (US), Ultraviolet light (UV) and combination (US + UV) assisted semiconductor catalysed degradation of organic pollutants in water: Oscillation in the concentration of hydrogen peroxide formed in situ”, Ultrasonic Sonochemistry, Cilt 21, 1787-1796, 2014.
  • Mahammuni, N.N. ve Adewuyi Y.G., “Advanced oxidation processes (AOPs) involving ultrasound for waste water treatment: A review with emphasis on cost estimation”, Ultrasonic Sonochemistry Cilt 17, 990-1003, 2010.
  • Beckett, M.A. ve Hua, I.,”Impact of Ultrasonic Frequency on Aqueous
  • Sonoluminescence and Sonochemistry”. J. Phys. Chem. A., Cilt 105, No 15, 3796-3802, 2001.
  • Schwarz, S.W., McCarthy, T.J., King, N., vd.” FDG PETtrace MicroLab: average [18F]FDG E.O.S. activity compared to the source of the [18O]water used” Proceedings of the Seventh Workshop on Targetry and Target Chemistry, pp. 246–247, 1997.
  • Masten, S.J. ve Davies, H.R.,” The use of ozonization to degrade organic contaminants in wastewaters”, Environmental Science and Technology, Cilt 28, No
  • , 180-185, 1994.
  • Naffrechoux, E., Chanoux, S., Petrier, C. ve Suptil, J.,” Sonochemical and photochemical oxidation of organic matter”, Ultrasonics Sonochemistry, Cilt 7,
  • –259, 2000.

Year 2017, Volume: 32 Issue: 2, 0 - 0, 13.06.2017

Nuray Yıldız Deniz Kıvrakdal Özkul

https://doi.org/10.17341/gazimmfd.322186

Abstract

References

  • Moon, W., Oh, S., Cheon, J. ve Chae, W., “Simple purification of recovered [18O]H2O by UV, ozone and solid-phase extraction methods”, Applied Radiation and Isotopes , Cilt 65, No 6, 635-40, 2007.
  • Fawdry, R. M., “A simple effective method for estimating the [18O] enrichment of water mixtures”, Applied Radiation and Isotopes Cilt 60, 23-26, 2004.
  • Kitano, H., Magata, Y., Tanaka, A. ve Mukaı, T,. “ Performance assessment of O-18 water purifier”, Annals of Nuclear Medicine, Cilt 15, No.1, 75-78, 2001
  • Nishijima, K., Kugea, Y., Tsukamotob, E. ve Sekic, K., “Increased [18F]2-fluoro- deoxy-d-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield”, Applied Radiation and Isotopes Cilt 57, 43-39, 2002.
  • Ito, S., Sakane, H., Deji, S. Ve Saze, T.,” Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesi”, Applied Radiation and Isotopes Cilt 64, 298- 305, 2006.
  • Huang, B., Channing, M., Plascjak, P. ve Kiesewetter, D.,” Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography”, Nuclear Medicine and Biology, Cilt 30, 785-790, 2003.
  • Asti, M., Grassi, E., Sghedoni, R. ve De Pietri, G. . “Purification by ozonolysis of
  • O enriched water after cyclotron ırradiation and the utilization of the purified
  • water for the purification [18F]FDG” Applied Radiation and Isotopes, 65, 831-835,
  • Twenson, T.J., Berridge, M.S., Bolomey, L., vd.,. “Routine production of reactive flüorine-18 flouride salts from an oxygen-18 water target”, Nuclear Medicine and Biology Cilt 15, 499-504, 1988.
  • Berridge, M.S. ve Kjellström, R., “ Design and use of silver targets for [18F]flouride production”, Applied Radiation and Isotopes, Cilt 50, 699-705, 1999.
  • Weber, K., Marx, H., Vierling, J., Wittstadt, U. ve Eisenhut, M., “Electrolytic purification of [18O ] water. J. Labeled”, Compounds Radio-Pharmaceuticals, Cilt 46 (Suppl. 1) S279, 2003.
  • Mangner, T.J., Mulholland, G.K., Toorongian, S.A., Jewett, D.M. ve Kilbourn, M.R., “Purification of used O-18 target water by photochemical combustion”, Journal of Nuclear Medicine, Cilt 33, 982–983, 1992.
  • Armstrong, F.A., Williams, P.M. and Strickland, D.H.,” Photo-oxidation of organic matter in seawater by ultra-violet radiation, analytical and other applications”, Nature 211, 481-484. 1966.
  • Hernandez, R., Zappi, M., Colucci J. ve Jones, R., “ Comparing the performance of various advanced oxidation processes for treatment of acetone contaminated water”, Journal of Hazardous Materials, Cilt 92, 33–50, 2002
  • Park, H.S., Hwang, T.M., Kang, J.W., Choi, H., ve Oh, H.J., 2001.” Characterization of raw water for the ozone application measuring ozone consumption rate”. Water Research, Cilt 11, 2607–2614, 2001.
  • Goel, M., Hongqiang, H., Mujumdar, A.S. ve Ray M.B. ,”Sonochemical
  • decomposition of volatile and non-volatile organic compounds—a comparative
  • study”, Water Research, Cilt 38, 4247–4261, 2004.
  • Jyothi, K.P. Suguna Yesodharan, Yesodharan E.P., “Ultrasound (US), Ultraviolet light (UV) and combination (US + UV) assisted semiconductor catalysed degradation of organic pollutants in water: Oscillation in the concentration of hydrogen peroxide formed in situ”, Ultrasonic Sonochemistry, Cilt 21, 1787-1796, 2014.
  • Mahammuni, N.N. ve Adewuyi Y.G., “Advanced oxidation processes (AOPs) involving ultrasound for waste water treatment: A review with emphasis on cost estimation”, Ultrasonic Sonochemistry Cilt 17, 990-1003, 2010.
  • Beckett, M.A. ve Hua, I.,”Impact of Ultrasonic Frequency on Aqueous
  • Sonoluminescence and Sonochemistry”. J. Phys. Chem. A., Cilt 105, No 15, 3796-3802, 2001.
  • Schwarz, S.W., McCarthy, T.J., King, N., vd.” FDG PETtrace MicroLab: average [18F]FDG E.O.S. activity compared to the source of the [18O]water used” Proceedings of the Seventh Workshop on Targetry and Target Chemistry, pp. 246–247, 1997.
  • Masten, S.J. ve Davies, H.R.,” The use of ozonization to degrade organic contaminants in wastewaters”, Environmental Science and Technology, Cilt 28, No
  • , 180-185, 1994.
  • Naffrechoux, E., Chanoux, S., Petrier, C. ve Suptil, J.,” Sonochemical and photochemical oxidation of organic matter”, Ultrasonics Sonochemistry, Cilt 7,
  • –259, 2000.
There are 28 citations in total.

Details

Journal Section Makaleler
Authors

Nuray Yıldız

Deniz Kıvrakdal Özkul This is me

Publication Date June 13, 2017
Submission Date May 20, 2016
Published in Issue Year 2017 Volume: 32 Issue: 2

Cite

APA Yıldız, N., & Kıvrakdal Özkul, D. (2017). [18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi, 32(2). https://doi.org/10.17341/gazimmfd.322186
AMA Yıldız N, Kıvrakdal Özkul D. [18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi. GUMMFD. June 2017;32(2). doi:10.17341/gazimmfd.322186
Chicago Yıldız, Nuray, and Deniz Kıvrakdal Özkul. “[18F]Flor üretiminde Hedef Olarak kullanılan [18O]H2O içindeki Organik safsızlıkların Giderimi”. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi 32, no. 2 (June 2017). https://doi.org/10.17341/gazimmfd.322186.
EndNote Yıldız N, Kıvrakdal Özkul D (June 1, 2017) [18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi 32 2
IEEE N. Yıldız and D. Kıvrakdal Özkul, “[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi”, GUMMFD, vol. 32, no. 2, 2017, doi: 10.17341/gazimmfd.322186.
ISNAD Yıldız, Nuray - Kıvrakdal Özkul, Deniz. “[18F]Flor üretiminde Hedef Olarak kullanılan [18O]H2O içindeki Organik safsızlıkların Giderimi”. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi 32/2 (June 2017). https://doi.org/10.17341/gazimmfd.322186.
JAMA Yıldız N, Kıvrakdal Özkul D. [18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi. GUMMFD. 2017;32. doi:10.17341/gazimmfd.322186.
MLA Yıldız, Nuray and Deniz Kıvrakdal Özkul. “[18F]Flor üretiminde Hedef Olarak kullanılan [18O]H2O içindeki Organik safsızlıkların Giderimi”. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi, vol. 32, no. 2, 2017, doi:10.17341/gazimmfd.322186.
Vancouver Yıldız N, Kıvrakdal Özkul D. [18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi. GUMMFD. 2017;32(2).