[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi

Yıl 2017, Cilt: 32 Sayı: 2, 0 - 0, 13.06.2017

Nuray Yıldız , Deniz Kıvrakdal Özkul

https://doi.org/10.17341/gazimmfd.322186

Öz

 

 

Bu çalışmada, F¹⁸[FDG] sentezi için gerekli olan olan ¹⁸F üretiminde kullanılmış  [¹⁸O]H₂O’deki, organik safsızlıkların giderilmesi için ozonlama, ultrasonikasyon ve damıtma yöntemleri ayrı ayrı ve birleştirilmiş olarak örneklere uygulanmıştır.

Organik safsızlıkların giderilmesi için belirlenen yöntemler ilk olarak hazırlanan model çözeltilere uygulanmıştır. Sonuçlar  ozon+ultrasonikasyon yönteminin ışınlanmış [¹⁸O]H₂O’i saflaştırmak için en uygun yöntem olduğunu göstermiştir. Bu yöntemle saflaştırılan [¹⁸O]H₂O ile [¹⁸F]flor ve [¹⁸F]FDG üretimi yapılmış, saflaştırılmış [¹⁸O]H₂O ile % 69 verim elde edilirken, yeni [¹⁸O]H₂O ile % 72 verim elde edilmiştir. Elde edilen sonuçlar ışınlanmış [¹⁸O]H₂O içindeki safsızlıklar giderilerek, kliniklerde  tekrar kullanılabileceğini göstermiştir.

Anahtar Kelimeler

[18O]H2O, [18 F] Flor, siklotron, ultrasonikasyon, ozonlama

Kaynakça

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