Abstract
Ghrelin is a recently discovered hormone
that has been shown to stimulate growth hormone (GH) release via activation of
the GH secretagogue reseptor. Ghrelin plays a role in energy homeostasis via
appetite, hunger sensation and food intake stimulation. This review will
attempt to update the knowledge of ghrelin on the body weight regulation and
the effect of exercise training on ghrelin concentration. Controversial data on
ghrelin concentration during exercise in human subjects have been published. It
can be concluded that the relationship between physical exercise and the plasma
concentration of ghrelin is not clear. The reasons for discrepancies among
studies could be the differences in duration, intensity and frequency of the
exercise employed in each study.
Keywords
References
- Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a Growth-Hormone- Releasing Acylated Peptide From Stomach. Nature 1999; 402: 656-660.
- Tschop M., Smiley D.L., Heimman M.L., Ghrelin Induces Adiposity in Rodents. Nature 2000; 407: 908-913.
- Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., Matsukura S. Arole for Ghrelin in the Central Regulation of Feeding. Nature 2001; 409: 194-198.
- Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M.A., Kasuga M. Ghrelin is an Appetite- Stimulatory Signal From Stomach With Structural Resemblance to Motilin. Gastroenterology 2001; 120: 337-345.
- Wren A.M., Seal L.J., Cohen J.A., Brynes A.E., Frost G.S., Murphy K.G., Dhillo W.S., Ghatei M.A. Bloom S.R., Ghrelin Enhances Appetite and Increases Food Intake in Humans, J Clin Endocrinol Metab, 2001; 86: 5992-5995.
Abstract
Ghrelin, büyüme hormonu salgılatıcı reseptörü aktive ederek büyüme
hormonu (BH) salimini uyaran yeni bir hormondur. Ghrelin ayrıca iştah, açlık
hissi ve besin alımını uyararak enerji homeostazisinde rol oynamaktadır. Bu
derleme akut ve kronik egzersizin ghrelin konsantrasyonu üzerindeki etkileri ve
ghrelinin vücut ağırlığı düzenlenmesi üzerindeki güncel bilgileri içermektedir.
insan denekleri üzerinde yapılan çalışmalarda egzersiz esnasındaki ghrelin
konsantrasyonu verileri oldukça çelişkilidir. Sonuç olarak fiziksel egzersiz
ile plazma ghrelin konsantrasyonu arasındaki ilişki tam olarak
aydınlatılabilmiş değildir. Bunun temel nedeni yapılmış olan araştırmalarda
kullanılan egzersiz şiddeti, sıklığı ve süresindeki farklılıklar olabilir.
References
- Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a Growth-Hormone- Releasing Acylated Peptide From Stomach. Nature 1999; 402: 656-660.
- Tschop M., Smiley D.L., Heimman M.L., Ghrelin Induces Adiposity in Rodents. Nature 2000; 407: 908-913.
- Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., Matsukura S. Arole for Ghrelin in the Central Regulation of Feeding. Nature 2001; 409: 194-198.
- Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M.A., Kasuga M. Ghrelin is an Appetite- Stimulatory Signal From Stomach With Structural Resemblance to Motilin. Gastroenterology 2001; 120: 337-345.
- Wren A.M., Seal L.J., Cohen J.A., Brynes A.E., Frost G.S., Murphy K.G., Dhillo W.S., Ghatei M.A. Bloom S.R., Ghrelin Enhances Appetite and Increases Food Intake in Humans, J Clin Endocrinol Metab, 2001; 86: 5992-5995.
Details
| Subjects | Sports Medicine |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | July 15, 2008 |
| Submission Date | March 14, 2017 |
| Acceptance Date | November 3, 2008 |
| Published in Issue | Year 2008 Volume: 13 Issue: 3 |
Gazi Journal of Physical Education and Sports Sciences is a scientific and peer-reviewed journal published quarterly.